Studies on gene expression using the operator-repressor system of bacteriophage lambda macromolecular interactions leading to high fidelity of protein synthesis
Returning to India in 1986, he joined Bose Institute, Kolkata as a senior lecturer in the department of biophysics.[4] He served the Institute till 2004 holding positions of reader and then professor of biophysics when he moved to the Indian Institute of Chemical Biology (IICB) as its director.[6] After completing 10 years as the director of IICB, he returned to Bose Institute in 2014 as a senior professor and dean of studies. While at IICB, he has served the nation in several different high-level capacities such as the founder-director-in-charge of the National Institute of Pharmaceutical Education and Research, Kolkata (NIPER) (2007–14), the cluster director of 11 Biological institutes of the Council of Scientific and Industrial Research (CSIR) (2009–14), member of the governing body of the CSIR and as a visiting professor at Osaka University (2012).[7] He has served as the president of the West Bengal Academy of Science and Technology. He is the founder-president of the Chemical Biology Society of India. He currently serves as a member of the board of directors of the International Chemical Biology Society. He also served as the director (officiating) of Bose Institute during the critical Centenary year.[8][citation needed] In addition, Roy played the very crucial role as an advisory committee member to successfully conduct the 'International Conference on Genome Biology 2019' hosted by the School of Biological Sciences (SBS), Madurai Kamaraj University.[9]
Research
Roy's researches during his stint in the US was on protein folding and nuclear magnetic resonance studies of DNA[4] and those researches identified the first hydropathy model which helped in predicting the exteriors and interiors of proteins by analyzing sequence information.[7] He is also reported to have performed the complete assignment of a nucleic acid imino proton spectra using Nuclear Overhauser effect, regio-specific isotope labeling of sugars in nucleic acids and working along with Ad Bax and R. H. Griffey, developed an indirect 2D-NMR detection method, all reported to be for the first time.[7] Later focusing his attention on bacteriophage lambda, he studied the gene expression of the bacterial virus using its operator-repressor system.[10] Through his collaborative work with Sankar Adhya in 1998, he elucidated the role of differential contact in the transcription regulation mechanism and demonstrated the theory in many genetic regulatory circuits.[4] His current work is focused on peptidetherapeutics[7] and he holds patents for some of his work.[11][12][13]
Roy has published his research work through a number of articles published in peer-reviewed journals[note 1] and ResearchGate, an online repository of scientific papers, has listed 155 of them.[14] He is the Co-author of "Chemical Biology of the Genome" published by Elsevier/AP. He is a joint editor of Subcellular Biochemistry, volume on Proteins: Structure, Function, and Engineering published by Plenum Press, New York, USA and Protein-Protein interaction Regulators published by Royal Society of Chemistry, UK. He has guided around 30 scholars in their doctoral studies.[4] When the Chemical Biology Society of India was formed in 2013, he became its founder president and holds the position.[15] He is a former president of the West Bengal Academy of Science and Technology and is its incumbent vice president.[16]
Chemical Biology of the Genome by Siddhartha Roy & Tapas Kundu. 2021. Published by Elsevier/AP.
Protein-Protein interaction Regulators, edited by Siddhartha Roy & Haian Fu. 2021. Published by Royal Society of Chemistry, UK
Subcellular Biochemistry, Volume 24 on Proteins: Structure, Function, and Engineering, edited by B B Biswas & Siddhartha Roy. 1995. Published by Plenum Press, New York, USA.
Selected bibliography
Gitashri Naiya, Paromita Raha, Manas Mondal, Uttam Pal, Rajesh Saha, Susobhan Choudhury, Subrata Batabyal, Samir Kumar Pal, Dhananjay Bhattacharyya, Nakul Chandra Maiti, Siddhartha Roy (June 2016). "Conformational Selection Underpins Recognition of Multiple DNA sequences by Proteins and Consequent Functional Actions". Physical Chemistry Chemical Physics. 18 (31): 21618–21628. Bibcode:2016PCCP...1821618N. doi:10.1039/C6CP03278H. PMID27426617.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Samir Kumar Pal, Susobhan Choudhury, Basusree Ghosh, Priya Singh, Raka Ghosh, Siddhartha Roy (June 2016). "Ultrafast Differential Flexibility of Cro-protein Binding Domains of Two Operator DNAs with Different Sequences". Physical Chemistry Chemical Physics. 18 (27): 17983–17990. Bibcode:2016PCCP...1817983C. doi:10.1039/C6CP02522F. PMID27326896.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Siddhartha Roy, Piya Ghosh, Neeladri Roy, Abhishek Mazumder, Koushik Roy, Asit Kumar Manna, Shampa Mallick, Israr Ahmed (May 2012). "Peptide based Molecules as Protein-Protein Interaction Inhibitors: Tools for Chemical Genetics and Therapy". Current Chemical Biology. 6 (2): 145–163. doi:10.2174/2212796811206020145.{{cite journal}}: CS1 maint: multiple names: authors list (link)
1st Subhendu Bandyopadhyay, B. Ghosh, Parasuraman Jaisankar, Bikas C Pal, Siddhartha Roy, Nath Paul, Arjun Ram, U. Mabalirajan, Nahid Ali, Arun Bandyopadhyay, Aditya Konar, J. Bagchi Chakraborty, I. Choudhury Mukherjee, Jaydeep Chaudhuri, Sanjit Kumar Mahato, A. Manna, Roma Sinha, Pradyot Bhattacharya, J. Vinayagam, D. P. Jana, Sudeshna Chowdhury (April 2011). "Inhibitors of IL-4 and IL-5 for the treatment of bronchial asthma (Patent 1032DEL2011)". {{cite journal}}: Cite journal requires |journal= (help)CS1 maint: multiple names: authors list (link) CS1 maint: numeric names: authors list (link)
