S3608

S3608

S3608

S3608
Identifiers
  • 2-[4-(2,3-dihydro-1-benzofuran-5-ylmethyl)piperazin-1-yl]-1,3-thiazole
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.054.333 Edit this at Wikidata
Chemical and physical data
FormulaC16H19N3OS
Molar mass301.41 g·mol−1
3D model (JSmol)
  • C1COC2=C1C=C(C=C2)CN3CCN(CC3)C4=NC=CS4
  • InChI=1S/C16H19N3OS/c1-2-15-14(3-9-20-15)11-13(1)12-18-5-7-19(8-6-18)16-17-4-10-21-16/h1-2,4,10-11H,3,5-9,12H2
  • Key:PZGCFBVHUMLXBW-UHFFFAOYSA-N

S3608 is a piperazine derivative related to piribedil, which similarly acts as a dopamine D2 and D3 receptor agonist.[1][2][3][4]

References

  1. ^ Poignant JC, Gressier H, Petitjean M, Regnier G, Canevari R (October 1975). "A new central direct dopaminergic stimulant: 1-(Coumaran-5-yl methyl)-4-(2-thiazolyl) piperazine hydrochloride (S 3608)". Experientia. 31 (10): 1204–1205. doi:10.1007/BF02326795. PMID 1243126.
  2. ^ Hall MD, Jenner P, Marsden CD (January 1983). "Differential labelling of dopamine receptors in rat brain in vivo: comparison of [3H]piribedil, [3H]S 3608 and [3H]N,n-propylnorapomorphine". European Journal of Pharmacology. 87 (1): 85–94. doi:10.1016/0014-2999(83)90053-5. PMID 6188621.
  3. ^ Caccia S, Notarnicola A, Fong MH, Benfenati E (January 1984). "Identification and quantitation of 1-arylpiperazines, metabolites resulting from side-chain cleavage of (4-substituted aryl-1-piperazinyl)alkyl heterocyclic derivatives in rat plasma and brain". Journal of Chromatography. 283: 211–221. doi:10.1016/s0021-9673(00)96256-3. PMID 6707118.
  4. ^ Offermeier J, van Rooyen JM (March 1986). "A comparative study of the locomotor activity effects of apomorphine and the "atypical dopamine agonists" (piribedil and S3608)". Life Sciences. 38 (10): 895–903. doi:10.1016/0024-3205(86)90257-2. PMID 3081774.

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