S100G

See also: Calbindin

S100G
Identifiers
Aliases	S100G, CABP, CABP1, CABP9K, CALB3, S100 calcium binding protein G
External IDs	OMIM: 302020; MGI: 104528; HomoloGene: 36150; GeneCards: S100G; OMA:S100G - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp22.2 Start 16,650,158 bp[1] End 16,654,670 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X F4 Start 161,744,988 bp[2] End 161,747,595 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa duodenum Achilles tendon epithelium of colon corpus callosum face right uterine tube endometrium sensory nervous system sensory organ Top expressed in duodenum yolk sac right kidney connecting tubule human kidney distal tubule right lung lobe uterus left lung distal convoluted tubule More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 795 12309 Ensembl ENSG00000169906 ENSMUSG00000040808 UniProt P29377 P97816 RefSeq (mRNA) NM_004057 NM_009789 RefSeq (protein) NP_004048 NP_033919 Location (UCSC) Chr X: 16.65 – 16.65 Mb Chr X: 161.74 – 161.75 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

S100 calcium-binding protein G (S100G) is a protein that in humans is encoded by the S100G gene.^[5][6][7]

This gene encodes calbindin D9K, a vitamin D-dependent calcium-binding protein. This cytosolic protein belongs to a family of calcium-binding proteins that includes calmodulin, parvalbumin, troponin C, and S100 protein. In the intestine, the protein is vitamin D-dependent and its expression correlates with calcium transport activity. The protein may increase Ca²⁺ absorption by buffering Ca²⁺ in the cytoplasm and increase ATP-dependent Ca²⁺ transport in duodenal basolateral membrane vesicles.^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000169906 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040808 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Howard A, Legon S, Spurr NK, Walters JR (1992). "Molecular cloning and chromosomal assignment of human calbindin-D9k". Biochem Biophys Res Commun. 185 (2): 663–9. doi:10.1016/0006-291X(92)91676-H. PMID 1610358.
6. Jeung EB, Krisinger J, Dann JL, Leung PC (Sep 1992). "Molecular cloning of the full-length cDNA encoding the human calbindin-D9k". FEBS Lett. 307 (2): 224–8. doi:10.1016/0014-5793(92)80772-9. PMID 1379540. S2CID 27787157.
7. "Entrez Gene: S100G S100 calcium binding protein G".

Further reading

• Balmain N (1991). "Calbindin-D9k. A vitamin-D-dependent, calcium-binding protein in mineralized tissues". Clin. Orthop. Relat. Res. (265): 265–76. PMID 2009668.
• Fleet JC, Hock JM (1995). "Identification of osteocalcin mRNA in nonosteoid tissue of rats and humans by reverse transcription-polymerase chain reaction". J. Bone Miner. Res. 9 (10): 1565–73. doi:10.1002/jbmr.5650091009. PMID 7817802. S2CID 1687493.
• Jeung EB, Leung PC, Krisinger J (1994). "The human calbindin-D9k gene. Complete structure and implications on steroid hormone regulation". J. Mol. Biol. 235 (4): 1231–8. doi:10.1006/jmbi.1994.1076. PMID 8308886.
• Barley NF, Prathalingam SR, Zhi P, et al. (1999). "Factors involved in the duodenal expression of the human calbindin-D9k gene". Biochem. J. 341 (3): 491–500. doi:10.1042/0264-6021:3410491. PMC 1220384. PMID 10417310.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wang L, Klopot A, Freund JN, et al. (2004). "Control of differentiation-induced calbindin-D9k gene expression in Caco-2 cells by cdx-2 and HNF-1α". Am. J. Physiol. Gastrointest. Liver Physiol. 287 (5): G943–53. doi:10.1152/ajpgi.00121.2004. PMC 2701355. PMID 15217781.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.