CDH12

CDH12
Identifiers
Aliases	CDH12, CDHB, cadherin 12
External IDs	OMIM: 600562; MGI: 109503; HomoloGene: 37873; GeneCards: CDH12; OMA:CDH12 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5p14.3 Start 21,750,673 bp[1] End 22,853,622 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 A2|15 8.25 cM Start 20,449,351 bp[2] End 21,589,619 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle middle temporal gyrus postcentral gyrus Brodmann area 23 right uterine tube primary visual cortex frontal pole Brodmann area 10 superior frontal gyrus entorhinal cortex Top expressed in internal pyramidal layer of neocortex external pyramidal layer of neocortex granular layer of dentate gyrus external granular layer dentate gyrus of hippocampal formation granule cell thalamus primary visual cortex epithalamus CA3 field dorsal cochlear nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding metal ion binding cytoskeletal protein binding protein homodimerization activity cadherin binding Cellular component integral component of membrane plasma membrane membrane cell surface catenin complex Biological process cell adhesion adherens junction organization homophilic cell adhesion via plasma membrane adhesion molecules cell-cell junction assembly calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell-cell adhesion mediated by cadherin cell-cell adhesion cell morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1010 215654 Ensembl ENSG00000154162 ENSMUSG00000040452 UniProt P55289 Q5RJH3 RefSeq (mRNA) NM_004061 NM_001317227 NM_001317228 NM_001008420 RefSeq (protein) NP_001304156 NP_001304157 NP_004052 NP_001351033 NP_001351034 NP_001351035 NP_001351036 NP_001351037 NP_001351038 NP_001008420 Location (UCSC) Chr 5: 21.75 – 22.85 Mb Chr 15: 20.45 – 21.59 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cadherin-12 is a protein that in humans is encoded by the CDH12 gene.^[5][6]

This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of an HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000154162 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040452 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Selig S, Bruno S, Scharf JM, Wang CH, Vitale E, Gilliam TC, Kunkel LM (Jun 1995). "Expressed cadherin pseudogenes are localized to the critical region of the spinal muscular atrophy gene". Proc Natl Acad Sci U S A. 92 (9): 3702–6. Bibcode:1995PNAS...92.3702S. doi:10.1073/pnas.92.9.3702. PMC 42029. PMID 7731968.
6. "Entrez Gene: CDH12 cadherin 12, type 2 (N-cadherin 2)".

Further reading

• Jean Weissenbach; Gyapay G; Dib C; et al. (1992). "A second-generation linkage map of the human genome". Nature. 359 (6398): 794–801. Bibcode:1992Natur.359..794W. doi:10.1038/359794a0. PMID 1436057. S2CID 4331117.
• Suzuki S, Sano K, Tanihara H (1991). "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue". Cell Regul. 2 (4): 261–70. doi:10.1091/mbc.2.4.261. PMC 361775. PMID 2059658.
• Gyapay G, Morissette J, Vignal A, et al. (1994). "The 1993-94 Généthon human genetic linkage map". Nat. Genet. 7 (2 Spec No): 246–339. doi:10.1038/ng0694supp-246. PMID 7545953. S2CID 24662426.
• Tanihara H, Sano K, Heimark RL, et al. (1995). "Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin". Cell Adhes. Commun. 2 (1): 15–26. doi:10.3109/15419069409014199. PMID 7982033.
• Selig S, Lidov HG, Bruno SA, et al. (1997). "Molecular characterization of Br-cadherin, a developmentally regulated, brain-specific cadherin". Proc. Natl. Acad. Sci. U.S.A. 94 (6): 2398–403. Bibcode:1997PNAS...94.2398S. doi:10.1073/pnas.94.6.2398. PMC 20099. PMID 9122206.
• Kremmidiotis G, Baker E, Crawford J, et al. (1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics. 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235.
• Chalmers IJ, Höfler H, Atkinson MJ (1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma". Genomics. 57 (1): 160–3. doi:10.1006/geno.1998.5717. PMID 10191097.
• Shimoyama Y, Tsujimoto G, Kitajima M, Natori M (2001). "Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins". Biochem. J. 349 (Pt 1): 159–67. doi:10.1042/0264-6021:3490159. PMC 1221133. PMID 10861224.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

External links

• CDH12 human gene location in the UCSC Genome Browser.
• CDH12 human gene details in the UCSC Genome Browser.