A guanylate cyclase activator (or "GUCA ") is a member of a group of proteins that upregulate guanylate cyclase . GUCA is also known as guanylate cyclase-activating protein (or "GCAP "). Its mutations can be associated with vision defects.[ 1]
There are five genes involved:
There are several therapeutic drugs that act as GUCA s, including linaclotide and plecanatide , which are guanylate cyclase-C receptor agonists . These drugs increase the secretion of bicarbonate and chloride in the colon and potentially relieve visceral hypersensitivity in IBS-C patients.[ 2]
References
^ Payne AM, Downes SM, Bessant DA, et al. (1998). "A mutation in guanylate cyclase activator 1A (GUCA1A) in an autosomal dominant cone dystrophy pedigree mapping to a new locus on chromosome 6p21.1" . Hum. Mol. Genet . 7 (2): 273–7. doi :10.1093/hmg/7.2.273 . PMID 9425234 .
^ Saps, Miguel; Miranda, Adrian (2017), Greenwood-Van Meerveld, Beverley (ed.), "Gastrointestinal Pharmacology" , Gastrointestinal Pharmacology , vol. 239, Cham: Springer International Publishing, pp. 147–176, doi :10.1007/164_2016_119 , ISBN 978-3-319-56359-6 , retrieved 2024-04-27
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