Phosphatidylcholine—dolichol O-acyltransferase

phosphatidylcholine-dolichol O-acyltransferase
Identifiers
EC no.	2.3.1.83
CAS no.	9012-30-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a phosphatidylcholine---dolichol O-acyltransferase (EC 2.3.1.83) is an enzyme that catalyzes the chemical reaction

3-sn-phosphatidylcholine + dolichol ${\displaystyle \rightleftharpoons }$ 1-acyl-sn-glycero-3-phosphocholine + acyldolichol

Thus, the two substrates of this enzyme are 3-sn-phosphatidylcholine and dolichol, whereas its two products are 1-acyl-sn-glycero-3-phosphocholine and acyldolichol.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is 3-sn-phosphatidylcholine:dolichol O-acyltransferase.

References

• Keenan RW, Kruczek ME (1976). "The esterification of dolichol by rat liver microsomes". Biochemistry. 15 (7): 1586–91. doi:10.1021/bi00652a032. PMID 4095.
• Radominska-Pyrek A, Chojnacki T, Zulczyk W (1979). "Acyl esters of polyprenols: specificity of microsomal transacylase for polyprenols of different chain length and saturation". Acta Biochim. Pol. 26 (1–2): 125–34. PMID 506613.