Slotemaker de Bruïne applied at the Utrecht University in June 1889 majoring in Theology and obtaining a Bachelor of Theology degree in July 1891 and worked as a student researcher before graduating with a Master of Theology degree in July 1894 and later got a doctorate as an Doctor of Theology in June 1896 and a Doctor of Philosophy in July 1898. Slotemaker de Bruïne served as a Minister of the Dutch Reformed Church from August 1894 until March 1926 in Haulerwijk from August 1894 until May 1897 in Beilen from May 1897 until January 1900 in Middelburg from January 1900 until September 1903 in Nijmegen from September 1903 until December 1907 and in Utrecht from December 1907 until March 1916. Slotemaker de Bruïne also worked as editor of the newspaper De Voorzorg from April 1903 until November 1921 and was co-founder and editor-in-chief of Christian magazine Stemmen des Tijds from January 1911 until May 1941. Slotemaker de Bruïne worked as a professor of Theology and the History of Christianity and at the Utrecht University from March 1916 until April 1925. Slotemaker de Bruïne also worked as editor-in-chief of the party newspaperDe Nederlander from February 1921 until May 1941. Slotemaker de Bruïne was elected as a Member of the Senate after the Senate election of 1922, taking office on 25 July 1922. Slotemaker de Bruïne also served as Chairman of the Christian Historical Union from 15 April 1925 until 20 September 1926.
After a railway strike in 1903 he realised that the Church holds important social obligations and since then he has also participated in politics. In 1926 he became minister of labour, in 1933 and 1935 minister of social affairs and education. On 1 May 1941 Slotemaker de Bruine died in Wassenaar.
