Indole-3-acetaldehyde reductase (NADH)

indole-3-acetaldehyde reductase (NADH)
Identifiers
EC no.	1.1.1.190
CAS no.	58875-06-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, an indole-3-acetaldehyde reductase (NADH) (EC 1.1.1.190) is an enzyme that catalyzes the chemical reaction

(indol-3-yl)ethanol + NAD⁺ ${\displaystyle \rightleftharpoons }$ (indol-3-yl)acetaldehyde + NADH + H⁺

Thus, the two substrates of this enzyme are (indol-3-yl)ethanol and NAD⁺, whereas its 3 products are (indol-3-yl)acetaldehyde, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (indol-3-yl)ethanol:NAD⁺ oxidoreductase. Other names in common use include indoleacetaldehyde reductase, indole-3-acetaldehyde reductase (NADH), and indole-3-ethanol:NAD⁺ oxidoreductase. This enzyme participates in tryptophan metabolism.

References

• Brown HM, Purves WK (1976). "Isolation and characterization of indole-3-acetaldehyde reductases from Cucumis sativus". J. Biol. Chem. 251 (4): 907–13. PMID 2607.