of 3-ketosteroids into 3α-hydroxysteroids. The enzyme has various protein isoforms (isozymes). In humans, 3α-hydroxysteroid dehydrogenase is encoded by...

position, hydroxysteroids are referred to as sterols, with an example being cholesterol. Hydroxysteroid dehydrogenase Ketosteroid Hydroxysteroids at the...

catalyze the reduction of 17-ketosteroids and the dehydrogenation of 17β-hydroxysteroids in steroidogenesis and steroid metabolism. This includes interconversion...

Hydroxysteroid dehydrogenases (HSDs) are a group of alcohol oxidoreductases that catalyze the dehydrogenation of hydroxysteroids. These enzymes also catalyze...

enzymes involved in steroid metabolism, like 11β-hydroxylase or 3β-hydroxysteroid dehydrogenase. It has a prevalence between 0.1% and 2% depending on...

In enzymology, 12alpha-hydroxysteroid dehydrogenase (EC 1.1.1.176) is an enzyme that catalyzes the chemical reaction cholic acid + NADP+       H+   H+...

Corticosteroid 11-β-dehydrogenase isozyme 2 also known as 11-β-hydroxysteroid dehydrogenase 2 is an enzyme that in humans is encoded by the HSD11B2 gene...

Congenital adrenal hyperplasia due to 3β-hydroxysteroid dehydrogenase deficiency is an uncommon form of congenital adrenal hyperplasia (CAH) resulting...

addition, it can be converted back into DHT via 3α-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase, bypassing conventional intermediates...

that catalyzes the reduction of keto sterols to the corresponding 3β-hydroxysteroids. For example: lophenol + NADP+       H+   H+   4α-methyllathosterone...

Δ5-4-isomerase, which catalyzes the oxidative conversion of Δ5-3β-hydroxysteroids to the Δ4-3-keto configuration and is, therefore, essential for the...

11β-Hydroxysteroid dehydrogenase (HSD-11β or 11β-HSD) enzymes catalyze the conversion of inert 11 keto-products (e.g. cortisone) to active cortisol, or...

In enzymology, 21-hydroxysteroid dehydrogenase (NADP+) (EC 1.1.1.151) is an enzyme that catalyzes the chemical reaction (5β)-pregnan-21-ol + NADP+    ...

11β-Hydroxysteroid dehydrogenase type 1, also known as cortisone reductase, is an NADPH-dependent enzyme highly expressed in key metabolic tissues including...

which encodes the 17β-hydroxysteroid dehydrogenase III enzyme, impairing of the conversion of 17-keto into 17-hydroxysteroids. The enzyme is involved...

D-bifunctional protein deficiency Other names 17β-hydroxysteroid dehydrogenase IV deficiency Specialty Medical genetics...

In enzymology, 7alpha-hydroxysteroid dehydrogenase (EC 1.1.1.159) is an enzyme that catalyzes the chemical reaction cholic acid + NAD+       H+   H+  ...

Pharma and its lead compound, a potentially first-in-class oral 17β-hydroxysteroid dehydrogenase type 1 inhibitor. In April 2026, India based Sun Pharma...

17β-Hydroxysteroid dehydrogenase 1 (17β-HSD1) is an enzyme that in humans is encoded by the HSD17B1 gene. This enzyme oxidizes or reduces the C17 hydroxy/keto...

HSD3B2 is a human gene that encodes for 3beta-hydroxysteroid dehydrogenase/delta(5)-delta(4)isomerase type II or hydroxy-delta-5-steroid dehydrogenase...

In enzymology, a 3-β(or 20-α)-hydroxysteroid dehydrogenase (EC 1.1.1.210) is an enzyme that catalyzes the chemical reaction 5α-androstan-3β,17β-diol +...

enzymology, a 7beta-hydroxysteroid dehydrogenase (NADP+) (EC 1.1.1.201) is an enzyme that catalyzes the chemical reaction a 7beta-hydroxysteroid + NADP+ ⇌ {\displaystyle...

\rightleftharpoons } 16beta-hydroxysteroid Hence, this enzyme has one substrate, 16alpha-hydroxysteroid, and one product, 16beta-hydroxysteroid. This enzyme belongs...

CD, Carroll BR, UHRI B (1957). "Comparisons of the oxidation of C19-hydroxysteroids by guinea pig liver homogenates". J. Biol. Chem. 224 (2): 811–8. doi:10...

3-Hydroxysteroid dehydrogenase (3-HSD) may refer to: 3α-Hydroxysteroid dehydrogenase (3α-HSD) 3β-Hydroxysteroid dehydrogenase (3β-HSD) This set index...

CYP2C19 leading to 4'-hydroxybupropion. The reductive pathways are by 11β-hydroxysteroid dehydrogenase type 1 in the liver and AKR7A2/AKR7A3 in the intestine...

Glycyrrhizin (glycyrrhizic acid or glycyrrhizinic acid) is the chief sweet-tasting constituent of Glycyrrhiza glabra (liquorice) root. Structurally, it...

monooxygenases, mainly, 6β-hydroxysteroid dehydrogenase (CYP3A4). 6β-hydroxycortisol is used as a biomarker of 6β-hydroxysteroid dehydrogenase (CYP3A4) activity...

The enzyme 5α-hydroxysteroid dehydratase (EC 4.2.1.62) catalyzes the chemical reaction 5α-ergosta-7,22-diene-3β,5-diol ⇌ {\displaystyle \rightleftharpoons...

natural steroids androstanediol via 17β-hydroxysteroid dehydrogenase or from androstanedione via 3β-hydroxysteroid dehydrogenase. Epiandrosterone is used...

change in 46,XY persons with 5alpha-reductase-2 deficiency and 17beta-hydroxysteroid dehydrogenase-3 deficiency". Archives of Sexual Behavior. 34 (4): 399–410...

(respectively) similarly) are known to be potent inhibitors of 11β-hydroxysteroid dehydrogenase (11β-HSD), which is responsible for the biosynthesis of...

mutations in the HSD11B2 gene, which encodes the kidney isozyme of 11β-hydroxysteroid dehydrogenase type 2. In an unaffected individual, this isozyme inactivates...

17)alpha-hydroxysteroid dehydrogenase (EC 1.1.1.209, 3(17)alpha-hydroxysteroid dehydrogenase) is an enzyme with systematic name 3(or 17)alpha-hydroxysteroid:NAD(P)+...

Aldo-keto reductase family 1 member C1 also known as 20α-hydroxysteroid dehydrogenase, 3α-hydroxysteroid dehydrogenase, and dihydrodiol dehydrogenase 1/2 is...

is not a substrate for 5α-reductase and is a poor substrate for 3α-hydroxysteroid dehydrogenase (3α-HSD), and therefore shows a high ratio of anabolic...

actions of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1). Cortisol can also be metabolized back into cortisone by the actions of 11β-hydroxysteroid dehydrogenase...

subsequently claimed by AstraZeneca as an inhibitor of the enzyme 11β-Hydroxysteroid dehydrogenase type 1. No other pharmacological data has been disclosed...

very potent competitive inhibitor of both isoforms (1 and 2) of 11β-hydroxysteroid dehydrogenase (11β-HSD). It is notably not metabolized by 11β-HSD2....

Rosolowsky E (2016). "46, XY disorder of sex development due to 17-beta hydroxysteroid dehydrogenase type 3 deficiency: a plea for timely genetic testing"...

Etiocholanolone 17-Ketosteroids are endogenous steroid hormones. Hydroxysteroid Hydroxysteroid dehydrogenase 17-Ketosteroids at the U.S. National Library of...

is not a substrate for 5α-reductase and is a poor substrate for 3α-hydroxysteroid dehydrogenase (3α-HSD), and therefore shows a high ratio of anabolic...

Estradiol 17beta-dehydrogenase Testosterone 17beta-dehydrogenase 17β-Hydroxysteroid dehydrogenase (17β-HSD, HSD17B), also 17-ketosteroid reductases (17-KSR)...

Aldo-keto reductase family 1 member C4, also known as 3α-Hydroxysteroid dehydrogenase type 1 (3α-HSD1), is an enzyme that in humans is encoded by the AKR1C4...

3α-HSDTooltip 3α-Hydroxysteroid dehydrogenases, 3β-HSDsTooltip 3β-Hydroxysteroid dehydrogenases, 5β-reductases, 11β-HSDsTooltip 11β-Hydroxysteroid dehydrogenases...

(January 2001). "Chalcones are potent inhibitors of aromatase and 17beta-hydroxysteroid dehydrogenase activities". Life Sciences. 68 (7): 751–61. doi:10...

Pioglitazone, sold under the brand name Actos among others, is an anti-diabetic medication used to treat type 2 diabetes. It may be used with metformin...

In enzymology, a 12beta-hydroxysteroid dehydrogenase (EC 1.1.1.238) is an enzyme that catalyzes the chemical reaction 3alpha,7alpha,12beta-trihydroxy-5beta-cholanate...

various forms: 21-hydroxylase, 17α-hydroxylase, 11β-hydroxylase and 3β-hydroxysteroid dehydrogenase), lipoid CAH due to deficiency of StAR and mitochondrial...

is an endogenous metabolite of progesterone which is formed by 20β-hydroxysteroid dehydrogenase (20β-HSD). It is a progestogen similarly to progesterone...

as peroxisomal multifunctional enzyme type 2 (MFP-2), as well as 17β-hydroxysteroid dehydrogenase type IV (17β-HSD type IV) is a protein that in humans...

Liquorice (Commonwealth English) or licorice (American English; see spelling differences; IPA: /ˈlɪkərɪʃ, -ɪs/ LIK-ər-ish, -⁠iss) is the common name of...

Mensah-Nyagan AG (April 2008). "The biological activity of 3alpha-hydroxysteroid oxido-reductase in the spinal cord regulates thermal and mechanical...

result in an apparent vulva. Ambiguous genitalia in XY males with 3β-hydroxysteroid dehydrogenase deficiency (3β-HSD2D). In females, hypogonadism can cause...

Indometacin, also known as indomethacin, is a nonsteroidal anti-inflammatory drug (NSAID) commonly used as a prescription medication to reduce fever, pain...

C24 Cholane Bile acid C27 Cholestane Functional group 17-Ketosteroid Hydroxysteroid Halogenated steroid Elements removed Norsteroid Secosteroid Elements...

subsequent conversion of DHEA to androstenedione via the enzyme 3β-hydroxysteroid dehydrogenase. The secondary pathway involves conversion of 17α-hydroxyprogesterone...

In enzymology, a sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating) (EC 1.1.1.170) is an enzyme that catalyzes the chemical reaction 3beta-hy...

glucocorticosteroids and androstenedione through the activity of 3α-hydroxysteroid dehydrogenase. Measurements of 17α-hydroxypregnenolone are useful in...

Simvastatin, sold under the brand name Zocor among others, is a statin, a type of lipid-lowering medication. It is used along with exercise, diet, and...

the skin of reductive 17β-hydroxysteroid dehydrogenase, and oxidative 3α-hydroxysteroid dehydrogenase and 3β-hydroxysteroid dehydrogenase enzymes. In...

activities in humans. The compound is synthesized from androstadienol by 3β-hydroxysteroid dehydrogenase, and can be converted into androstenone (a more potent...

the C1 and C2 positions, metenolone is resistant to metabolism by 3α-hydroxysteroid dehydrogenase (3α-HSD). As such, unlike DHT and the closely related...

5β-dihydroprogesterone. Allopregnanolone is transformed back into 5α-DHP by 3α-hydroxysteroid oxidoreductase, and conversion of allopregnanolone into 5α-DHP is responsible...

17β-Hydroxysteroid dehydrogenase 2 (17β-HSD2) is an enzyme of the 17β-hydroxysteroid dehydrogenase (17β-HSD) family that in humans is encoded by the HSD17B2...

reported to act as an inhibitor of 17β-hydroxysteroid dehydrogenases. 16-Ketoestrone can be converted by 16α-hydroxysteroid dehydrogenase into estriol in the...

healthy individual. The mechanism consists of an enzyme called 11β-Hydroxysteroid dehydrogenase (11β-HSD). This enzyme co-localizes with intracellular...

The drug specifically acts as a centrally penetrant inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) and thereby inhibits the synthesis of...

In enzymology, a 3alpha(or 20beta)-hydroxysteroid dehydrogenase (EC 1.1.1.53) is an enzyme that catalyzes the chemical reaction 3α-Androstanediol + NAD+...

and kidney ischemia. Excess consumption of licorice can inhibit 11β-hydroxysteroid dehydrogenase and cause similar symptoms as PA. Chrétien syndrome, Gitelman...

in axillary odor. It is produced from androstenone via the enzyme 3β-hydroxysteroid dehydrogenase. Unlike its C3α epimer 3α-androstenol, 3β-androstenol...

mikrobiologische Hydrierung mit Streptomyces hydrogenans" [Production of 20 beta-hydroxysteroids from 17 alpha, 21-dihydroxy-20-ketosteroids by microbiological hydration...

Studies have demonstrated that some of these products inhibit 17β-hydroxysteroid dehydrogenase and 17,20-lyase, which catalyzes the conversion of...

ergosterol and 7-dehydrocholesterol). Cholesterol Ergosterol Hopanoids Hydroxysteroid Phytosterol Steroids Zoosterol Zymosterol The word stenol exists to...

Epigallocatechin gallate (EGCG), also known as epigallocatechin-3-gallate, is the ester of epigallocatechin and gallic acid, and is a type of catechin...

in the stop codon and a novel missense mutation in the type II 3beta-hydroxysteroid dehydrogenase (3beta-HSD) gene causing, respectively, nonclassic and...

Bile salt sulfotransferase also known as hydroxysteroid sulfotransferase (HST) or sulfotransferase 2A1 (ST2A1) is an enzyme that in humans is encoded by...

side-chain cleavage enzyme, 17α-hydroxylase, 17,20-lyase, 5α-reductase, 3β-hydroxysteroid dehydrogenase, 11β-hydroxylase, 21-hydroxylase, and aldosterone synthase...

to androstenedione by 3β-hydroxysteroid dehydrogenase (3β-HSD) and then finally converted to testosterone by 17β-hydroxysteroid dehydrogenase (HSD17B)....

Genistein (C15H10O5) is a plant-derived, aglycone isoflavone. Genistein has the highest content of all isoflavones in soybeans and soy products, such as...

member of the cytochrome P450 family of enzymes), 5α-Reductase and 3α-Hydroxysteroid dehydrogenase. Steroids are primarily oxidized by cytochrome P450 oxidase...

member C3 (AKR1C3), also known as 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD5, HSD17B5) or 3α-hydroxysteroid dehydrogenase type 2 (3α-HSD2) is a steroidogenic...

is described as a very poor anabolic agent due to inactivation by 3α-hydroxysteroid dehydrogenase (3α-HSD) in skeletal muscle tissue, similarly to DHT and...

3α-hydroxysteroid dehydrogenase are involved in the biosynthesis of inhibitory neurosteroids, while 3β-hydroxysteroid dehydrogenase and hydroxysteroid sulfotransferases...

including ethanol (beverage alcohol), retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein, known as ADH1B...

to 3β-hydroxysteroid dehydrogenase deficiency 5α-Reductase deficiency Androgen insensitivity syndrome Ovotesticular disorder 17β-Hydroxysteroid dehydrogenase...

C24 Cholane Bile acid C27 Cholestane Functional group 17-Ketosteroid Hydroxysteroid Halogenated steroid Elements removed Norsteroid Secosteroid Elements...

5β-reductase, dehydrogenation by 3α-hydroxysteroid dehydrogenase, 3β-hydroxysteroid dehydrogenase, and 17β-hydroxysteroid dehydrogenase, and conjugation....

rats produced male offspring with decreased levels of 3-β and 17-β-hydroxysteroid dehydrogenase, a gene that transcribes for proteins involved in the...

progesterone into 5α-dihydroprogesterone by 5α-reductase. After that, 3α-hydroxysteroid dehydrogenase converts this intermediate into allopregnanolone. Allopregnanolone...

deoxycorticosterone by the action of two enzymes, 5α-reductase type I and 3α-hydroxysteroid dehydrogenase. THDOC is a potent positive allosteric modulator of the...

Cyproterone acetate (CPA), sold alone under the brand name Androcur or with ethinylestradiol under the brand names Diane or Diane-35 among others, is an...

3α-hydroxysteroid dehydrogenases, including AKR1C2, are NAD(P)H-linked oxidoreductases that primarily catalyze the oxidation of 3α-hydroxysteroids to...

formed from bupropion via reduction of the ketone group primarily by 11β-hydroxysteroid dehydrogenase-1 and to a minor extent by aldo-keto reductases. It can...

Nandrolone is less susceptible to metabolism by 5α-reductase and 17β-hydroxysteroid dehydrogenase than testosterone. This results in it being transformed...

estradiol therapy. This appears to be due to a decrease in hepatic 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) activity and hence estradiol inactivation...

In enzymology, 21-hydroxysteroid dehydrogenase (NAD+) (EC 1.1.1.150) is an enzyme that catalyzes the chemical reaction (5β)-pregnan-21-ol + NAD+      ...

by 3β-hydroxysteroid dehydrogenase (androstadienol to androstadienone), 5α-reductase (androstadienone to androstenone), and 3α-hydroxysteroid dehydrogenase...

HSD3B1 is a human gene that encodes for a 3beta-hydroxysteroid dehydrogenase/delta(5)-delta(4)isomerase type I or hydroxy-delta-5-steroid dehydrogenase...

as acceptors. The systematic name for this enzyme class is 17alpha-hydroxysteroid:NAD(P)+ 17-oxidoreductase. Commonly used names include 17alpha-estradiol...

various forms: 21-hydroxylase, 17α-hydroxylase, 11β-hydroxylase and 3β-hydroxysteroid dehydrogenase), lipoid CAH due to deficiency of StAR and mitochondrial...

5α-reductase (as it is already 5α-reduced) and is a poor substrate for 3α-hydroxysteroid dehydrogenase (3α-HSD), and therefore shows a high ratio of anabolic...

In enzymology, a 3alpha-hydroxysteroid dehydrogenase (A-specific) (EC 1.1.1.213) is an enzyme that catalyzes the chemical reaction androsterone + NAD(P)+...

Hypertension and hypokalemia can also be seen with a deficiency of the 11-beta-hydroxysteroid dehydrogenase type 2 enzyme, which allows cortisols to stimulate aldosterone...

progesterone in the body by the actions of the enzymes 5α-reductase and 3β-hydroxysteroid dehydrogenase (with 5α-dihydroprogesterone as the intermediate in this...

5α-DHF can be further metabolized into 3α,5α-tetrahydrocortisol by 3α-hydroxysteroid dehydrogenase. "Hydrallostane". Azzouni F, Godoy A, Li Y, Mohler J (2012)...

encoded by the HSD17B8 gene. In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active...

enzyme). Cortisol is metabolized reversibly to cortisone by the 11-beta hydroxysteroid dehydrogenase system (11-beta HSD), which consists of two enzymes: 11-beta...

addition, metribolone was identified in 2010 as a potent inhibitor of 3β-hydroxysteroid dehydrogenase (3β-HSD) 1 and 2 (IC50 = 0.02 and 0.16 μM, respectively)...

NADP+ as acceptor. The systematic name of this enzyme class is 17beta-hydroxysteroid:NAD+ 17-oxidoreductase. Other names in common use include 17-ketoreductase...

of the androgen receptor (AR), and as an inhibitor of the enzymes 3β-hydroxysteroid dehydrogenase (3β-HSD), CYP11B1 (steroid 11β-hydroxylase), CYP21A2 (Steroid...

[citation needed] Umbelliferone is a potent inhibitor of type 3 17β-hydroxysteroid dehydrogenase, the primary enzyme responsible for the conversion of...

20-lyase inhibitors): inhibit the synthesis of androgens from pregnanes 3β-Hydroxysteroid dehydrogenase inhibitors (3β-HSD inhibitors): inhibit the conversion...

enzyme, corticosteroid 11-beta-dehydrogenase isozyme 2 (a.k.a. 11β-hydroxysteroid dehydrogenase 2; 11β-HSD2), that converts cortisol to inactive cortisone...

may be raised as females due to ambiguous or feminized genitalia. 17β-Hydroxysteroid dehydrogenase deficiency – a condition characterized by impaired androgen...

agent. This is attributed to its high affinity as a substrate for 3α-hydroxysteroid dehydrogenase (3α-HSD), which is highly expressed in skeletal muscle...

inhibitor of 3β-hydroxysteroid dehydrogenase (3β-HSD). As a result of this action, trilostane blocks the conversion of Δ5-3β-hydroxysteroids, including pregnenolone...

3-oxidoreductase. Other names in common use include 3beta-hydroxysteroid 5beta-oxidoreductase, and 3beta-hydroxysteroid 5beta-progesterone oxidoreductase. Enzyme 1...

at the skin of reductive 17β-hydroxysteroid dehydrogenase, oxidative 3α-hydroxysteroid dehydrogenase, and 3β-hydroxysteroid dehydrogenase enzymes. Gynecomastia...

to prevent overstimulation by glucocorticoids. This enzyme, 11-beta hydroxysteroid dehydrogenase type II (Protein:HSD11B2), catalyzes the deactivation...

(CAIS), 5-alpha-reductase 2 deficiency, pure gonadal dysgenesis, 17β-hydroxysteroid dehydrogenase deficiency, and mixed gonadal dysgenesis. Constitutional...

C19 steroids. In addition, the 3β-hydroxyl group is oxidized by 3β-hydroxysteroid dehydrogenase to produce androstenedione. In the final and rate limiting...

Threohydrobupropion is formed from bupropion via reduction of the ketone group by 11β-hydroxysteroid dehydrogenase-1 and aldo-keto reductases. It can also be formed from...

17β-Hydroxysteroid dehydrogenase 3 (17β-HSD3) is an enzyme that in humans is encoded by the HSD17B3 gene and is involved in androgen steroidogenesis. This...

Fisetin (7,3′,4′-flavon-3-ol) is a plant flavonol from the flavonoid group of polyphenols. It occurs in many plants where it serves as a yellow pigment...

into progesterone. The critical enzyme step is two-fold using a 3β-hydroxysteroid dehydrogenase and a Δ5-4 isomerase. The latter transfers the double...

is formed from androstenedione by 5α-reductase and from DHT by 17β-hydroxysteroid dehydrogenase. It has some androgenic activity. In female genital skin...

with corticosteroid receptors. Hydrocortisone is metabolized by 11β-hydroxysteroid dehydrogenases (11β-HSDs) into cortisone, an inactive metabolite. It...

C24 Cholane Bile acid C27 Cholestane Functional group 17-Ketosteroid Hydroxysteroid Halogenated steroid Elements removed Norsteroid Secosteroid Elements...

relative to estradiol. The liver as well as the uterus express 17β-hydroxysteroid dehydrogenase (17β-HSD), and this enzyme serves to inactivate estradiol...

microsomes by genistein, daidzein, coumestrol and C18-, C19- and C21 hydroxysteroids and ketosteroids". Steroids. 70 (8): 507–514. doi:10.1016/j.steroids...

catalyzed by steroid sulfatase, and of estrone into estradiol by 17β-hydroxysteroid dehydrogenase. CEEs (as Premarin) and estrone have been found to be...

Fluoxymesterone has been found to act as a potent inhibitor of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) (IC50Tooltip Half-maximal inhibitory...

The interconversion between estradiol and estrone is mediated by 17β-hydroxysteroid dehydrogenases (17β-HSDs), whereas the conversion of estrone into estrone...

is synthesized from progesterone via the enzymes 5β-reductase and 3α-hydroxysteroid dehydrogenase, with 5β-dihydroprogesterone occurring as a metabolic...

its lactone bridge, oxandrolone is resistant to inactivation by 3α-hydroxysteroid dehydrogenase in skeletal muscle. This resistance, in contrast to DHT...

adrenal tissue, testosterone, derived from androstenedione via 17β-hydroxysteroid dehydrogenase (17βHSD), is the precursor. Studies from the 1960s confirmed...

as an orally active version of this AAS. Due to inactivation by 3α-hydroxysteroid dehydrogenase (3α-HSD) in skeletal muscle, mestanolone is described...

cholesterol biosynthesis caused by a deficiency of the enzyme 3-beta-hydroxysteroid-delta-5-desaturase. This leads to a flaw in the conversion of lathosterol...

hormones (which are derived from pregnenolone) including progesterone 3β-Hydroxysteroid dehydrogenase inhibitors (3β-HSD inhibitors): inhibit the conversion...

17β-Hydroxysteroid dehydrogenase type 13 also known as 17β-HSD type 13 is an enzyme that in humans is encoded by the HSD17B13 gene. 17β-HSD13 is significantly...

prostate gland. In addition, unlike testosterone, DHT is inactivated by 3α-hydroxysteroid dehydrogenase (3α-HSD) into the very weak androgen 3α-androstanediol...

interconverted with methylprednisone. Hepatic metabolism is mediated by 11 beta-hydroxysteroid dehydrogenases (11[beta]-HSD) and 20-ketosteroid reductases. Methylprednisolone...

17-oxidoreductase. Other names in common use include 20alpha-hydroxysteroid dehydrogenase, 17beta,20alpha-hydroxysteroid dehydrogenase, 17beta-estradiol dehydrogenase...

substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is...

metabolites is catalyzed by the enzymes 5α- and 5β-reductase and 3α-hydroxysteroid dehydrogenase, and occurs primarily in the liver, but also occurs in...

sulfatase, pregnenolone sulfatase, phenolic steroid sulfatase, 3-beta-hydroxysteroid sulfate sulfatase, as well as by its systematic name steryl-sulfate...

epostane, mitotane, and trilostane inhibit the conversion of Δ5-3β-hydroxysteroids into Δ4-3-ketosteroids and thereby inhibit the production of most of...

of adrenal androgens and estrogens. The zona fasciculata has more 3β-hydroxysteroid dehydrogenase activity than the zona reticularis. Therefore, the zona...

the further reduction of these metabolites via 3α-hydroxysteroid dehydrogenase and 3β-hydroxysteroid dehydrogenase into the tetrahydrogenated allopregnanolone...

in this process include both mitochondrial and microsomal P450s and hydroxysteroid dehydrogenases. Usually a number of intermediate steps in which pregnenolone...

order solubility equation applied to polyfunctional molecules: The non-hydroxysteroids in aqueous and non aqueous solvents". Int J Pharm. 157 (2): 219–232...

acetate to abiraterone by esterases; abiraterone to Δ4-abiraterone by 3β-hydroxysteroid dehydrogenase/Δ5-4 isomerase; and Δ4-abiraterone to 3-keto-5α-abiraterone...

substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting...

other causes such as partial androgen insensitivity syndrome and 17β-hydroxysteroid dehydrogenase 3 deficiency. Hair on the face and body is reduced and...

by 3β-hydroxysteroid dehydrogenase type I into androstenedione, and androstenedione is aromatized into estrone. Then, placental 17β-hydroxysteroid dehydrogenase...

transformations are catalyzed by 5α- and 5β-reductase and 3α- and 3β-hydroxysteroid dehydrogenase both in the liver and in extrahepatic tissues such as...

The following is a partial list of the "D" codes for Medical Subject Headings (MeSH), as defined by the United States National Library of Medicine (NLM)...

In enzymology, 20-α-hydroxysteroid dehydrogenase (EC 1.1.1.149) is an enzyme that catalyzes the chemical reaction 17α,20α-dihydroxypregn-4-en-3-one + NADP+...

Cortisone reductase deficiency is caused by dysregulation of the 11β-hydroxysteroid dehydrogenase type 1 enzyme (11β-HSD1), otherwise known as cortisone...

Gerard (2001). "Chalcones are potent inhibitors of aromatase and 17β-hydroxysteroid dehydrogenase activities". Life Sciences. 68 (7): 751–61. doi:10...

in the body. Estrone can then be transformed into estradiol by 17β-hydroxysteroid dehydrogenase. Estropipate was introduced for medical use by Abbott...

aromatized to estrone, which is subsequently converted to estradiol via 17β-hydroxysteroid dehydrogenase (17β-HSD). During the reproductive years, most estradiol...

hydroxylation (via cytochrome P450 enzymes), dehydrogenation (via 17β-hydroxysteroid dehydrogenase), and conjugation (via sulfation and glucuronidation)...

(by 3α- and 3β-hydroxysteroid dehydrogenase) and, from them, respectively, etiocholanolone and epietiocholanolone (by 17β-hydroxysteroid dehydrogenase)...

enzymology, a 16alpha-hydroxysteroid dehydrogenase (EC 1.1.1.147) is an enzyme that catalyzes the chemical reaction a 16alpha-hydroxysteroid + NAD(P)+ ⇌ {\displaystyle...

Metyrapone, sold under the brand name Metopirone, is a medication which is used in the diagnosis of adrenal insufficiency and occasionally in the treatment...

physiologic doses this is prevented by rapid degradation of cortisol by 11β-hydroxysteroid dehydrogenase isoenzyme 2 (11β-HSD2) in mineralocorticoid target tissues...

partial androgen insensitivity syndrome, 5α-Reductase deficiency and 17β-Hydroxysteroid dehydrogenase III deficiency, stating that sexual attraction towards...

Security Department Hybrid Synergy Drive, a set of hybrid car technologies Hydroxysteroid dehydrogenase Hypoactive sexual desire, a disorder characterized as...

13 Jan. 2022. Lommer D, Dorfman RI, Forchelli E. Reversal of the 3 -hydroxysteroid dehydrogenase-isomerase reactions in rat adrenals. Steroidologia. 1970;1(3):175-82...

repressor of TGF-β pathways in myometrial cells. Aromatase and 17beta-hydroxysteroid dehydrogenase are aberrantly expressed in fibroids, indicating that...

C24 Cholane Bile acid C27 Cholestane Functional group 17-Ketosteroid Hydroxysteroid Halogenated steroid Elements removed Norsteroid Secosteroid Elements...

17α-dihydroxyprogesterone) and is reversibly formed from it by 11β-hydroxysteroid dehydrogenase, analogously to the reversible formation of cortisone...

can lead to pseudohyperaldosteronism. Through inhibition of 11-beta-hydroxysteroid dehydrogenase type 2 (11-beta-HSD2), glycyrrhizin allows cortisol to...

P450 (CYP1, 2, 3) – estrogen metabolism Hydroxysteroid dehydrogenases (and ketosteroid reductases) 3α-Hydroxysteroid dehydrogenase – androgen, progestogen...

estradiol valerate reduces the metabolism of estradiol valerate by 17β-hydroxysteroid dehydrogenase (17β-HSD). As approximately 80% of estradiol is metabolized...

C24 Cholane Bile acid C27 Cholestane Functional group 17-Ketosteroid Hydroxysteroid Halogenated steroid Elements removed Norsteroid Secosteroid Elements...

δ4-pregnenolone), is an endogenous steroid. It is biosynthesized by 3β-hydroxysteroid dehydrogenase from progesterone. Unlike 3α-dihydroprogesterone (3α-DHP)...

Hypertension-associated Primary aldosteronism Nasogastric suction 11β-hydroxysteroid dehydrogenase type 2 deficiency Congenital chloride diarrhea Liquorice...

inhibits Cholesterol side-chain cleavage enzyme (P450scc, CYP11A1) and 3α-hydroxysteroid dehydrogenase (3α-HSD). Leung-Gurung, Lucie; Escalante Cobb, Priscilla;...

steroidogenic enzymes cytochrome P450 side chain cleavage (CYP11A1) and 3 beta hydroxysteroid dehydrogenase (3βHSD). StAR was found to have an anti-apoptotic effect...

substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class III alcohol dehydrogenase is...

adrenal hyperplasia 3β-hydroxysteroid dehydrogenase 2 deficiency 17α-hydroxylase deficiency 17,20 lyase deficiency 17β-hydroxysteroid dehydrogenase deficiency...

1007/s004010051140. PMID 10787037. S2CID 125429. Seckl JR (1997). "11β-Hydroxysteroid Dehydrogenase in the Brain: A Novel Regulator of Glucocorticoid Action...

Trilostane, sold under the brand name Vetoryl, inhibits the 3-beta-hydroxysteroid dehydrogenase enzyme. The enzyme is responsible for the production of...

protein determine placental-specific expression of the Type I human 3beta-hydroxysteroid dehydrogenase gene, HSD3B1". Molecular Endocrinology. 18 (8): 2049–60...

3-beta-hydroxysteroid-Δ8,Δ7-isomerase Identifiers EC no. 5.3.3.5 Databases BRENDA enzyme data ExPASy NiceZyme view KEGG enzyme entry MetaCyc metabolic...

affinity. In addition, DHT is metabolized by 3α-hydroxysteroid dehydrogenase (3α-HSD) and 3β-hydroxysteroid dehydrogenase (3β-HSD) into 3α-androstanediol...

Meldrum C, et al. (February 2008). "Submicroscopic duplications of the hydroxysteroid dehydrogenase HSD17B10 and the E3 ubiquitin ligase HUWE1 are associated...

substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This gene is expressed in the stomach...

V, Faucher F, Breton R, Luu-The V (2005). "Characterization of 17α-hydroxysteroid dehydrogenase activity (17α-HSD) and its involvement in the biosynthesis...

The conversion of androstenedione to testosterone is catalyzed by 17β-hydroxysteroid dehydrogenase (17β-HSD), whereas the conversion of androstenedione and...

hormone receptor β (TRβ) agonist Emestedastat (UE-2343; Xanamem) – 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor (glucocorticoid synthesis...

into 16α-hydroxyestrone, and finally converted into estriol by 17β-hydroxysteroid dehydrogenase. 15α-Hydroxydehydroepiandrosterone Androstenedione...

Wolfgang (2014). "Identification and stress-induced expression of three 3β-hydroxysteroid dehydrogenases from Erysimum crepidifolium Rchb. and their putative...

is also partially but considerably oxidized into estromustine by 17β-hydroxysteroid dehydrogenases during the first pass. As such, EMP reaches the circulation...

20-lyase into androstenedione; and androstenedione is converted by 17β-hydroxysteroid dehydrogenases into testosterone. CYP17A1, the cytochrome P450 gene...

estrone is also formed reversibly from estradiol by the enzyme 17β-hydroxysteroid dehydrogenase (17β-HSD) in various tissues, including the liver, uterus...

are not further converted in the adrenal cortex if the cells lack 17β-Hydroxysteroid dehydrogenase. Instead, they are released into the blood stream and...

transformed into androstenedione by 3β-hydroxysteroid dehydrogenase (3β-HSD), and into androstenediol by 17β-hydroxysteroid dehydrogenase (17β-HSD). Then, androstenedione...

Jin Y, Penning TM (March 2001). "Steroid 5alpha-reductases and 3alpha-hydroxysteroid dehydrogenases: key enzymes in androgen metabolism". Best Pract. Res...

Rosiglitazone (trade name Avandia) is an antidiabetic drug in the thiazolidinedione class. It works as an insulin sensitizer, by binding to the PPAR in...

2-epimerase EC 5.1.99.1: methylmalonyl-CoA epimerase EC 5.1.99.2: 16-hydroxysteroid epimerase EC 5.1.99.3: allantoin racemase EC 5.1.99.4: α-methylacyl-CoA...

steroid + AH2 + O2 ⇌ {\displaystyle \rightleftharpoons } a 17alpha-hydroxysteroid + A + H2O The 3 substrates of this enzyme are steroid, an electron acceptor...

which was never marketed. It acts as a competitive inhibitor of 3β-hydroxysteroid dehydrogenase (IC50 = 1 μM), and thereby inhibiting the formation of...

that essentially metabolizes ethanol, retinol, aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. However, C4orf17 is not included...

1016/0010-7824(90)90034-S. PMID 2139843. Stalvey JR (July 2002). "Inhibition of 3beta-hydroxysteroid dehydrogenase-isomerase in mouse adrenal cells: a direct effect of testosterone"...

relevant activity. Medrogestone has been found to be an inhibitor of 3β-hydroxysteroid dehydrogenase/Δ5-4 isomerase in vitro, preventing conversion of pregnenolone...

5β-androstanediol (via 3β-hydroxysteroid dehydrogenase), and 3β,5β-androstanediol to epietiocholanolone (via 17β-hydroxysteroid dehydrogenase). Epietiocholanolone...

steroid hormones by the action of two enzymes, 5α-reductase and 3α-hydroxysteroid dehydrogenase (3α-HSD). These enzymes can be inhibited by 5α-reductase...

sulfatase) and estrone to estradiol (via inhibition of 17β-HSDTooltip 17β-hydroxysteroid dehydrogenase) at high concentrations (0.5–50 μM) and to stimulate the...

Zanoterone does not inhibit 5α-reductase, aromatase, or 3α- or 3β-hydroxysteroid dehydrogenase in vitro. The drug significantly increases testosterone...

debarquement Malakoplakia Malaria Male pseudohermaphroditism due to 17-beta-hydroxysteroid dehydrogenase deficiency Male pseudohermaphroditism due to 5-alpha-reductase...

lesser extent 3β-hydroxynoretynodrel, formed respectively by 3α- and 3β-hydroxysteroid dehydrogenases (AKR1C1–4), while the δ4-isomer norethisterone is a minor...

(cholesterole, dehydroepiandorosterone and pregnenolone) for the 3β-hydroxysteroid dehydrogenase (3βHSD) of endocrine system. It has been reported that...

flavonoids, tropoflavin does not show any inhibitory activity on 17β-hydroxysteroid dehydrogenase. Tropoflavin has also been observed to possess in vitro...

17beta-dehydrogenase (NADP)) is an enzyme with systematic name 17beta-hydroxysteroid:NADP+ 17-oxidoreductase. This enzyme catalyses the chemical reaction...

3(or 17)a-hydroxysteroid dehydrogenase - 3110001I22Rik - 3alpha-hydroxyglycyrrhetinate dehydrogenase - 4932414N04Rik - 3alpha-hydroxysteroid dehydrogenase...

16-ene-synthetase activity of CYP17A1, and is converted into androstadienone by 3β-hydroxysteroid dehydrogenase. Male sweat contains approximately five times as much...

C24 Cholane Bile acid C27 Cholestane Functional group 17-Ketosteroid Hydroxysteroid Halogenated steroid Elements removed Norsteroid Secosteroid Elements...

Mohrenweiser HW, Ramagli LS, Siciliano MJ, Weinshilboum RM (Dec 1998). "Human hydroxysteroid sulfotransferase SULT2B1: two enzymes encoded by a single chromosome...

7beta-hydroxy-epiandrosterone as substrates and inhibitors for the human 11beta-hydroxysteroid dehydrogenase type 1". J. Steroid Biochem. Mol. Biol. 105 (1–5): 159–65...

progestins. MPA has been found to act as a competitive inhibitor of rat 3α-hydroxysteroid dehydrogenase (3α-HSD). This enzyme is essential for the transformation...

alcohol sulfotransferase is also known by several other names including "hydroxysteroid sulfotransferase," "steroid sulfokinase," and "estrogen sulfotransferase...

Daidzein (7-hydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one) is a naturally occurring compound found exclusively in soybeans and other legumes, and structurally...

for fetal lung maturation. Additionally, there is an abundance of 11β-hydroxysteroid dehydrogenase 1 expressed in the foetal membranes. This enzyme converts...

mice. Unlike CPA, cyproterone seems to show some inhibition of 17β-hydroxysteroid dehydrogenase and 5α-reductase in vitro. In contrast to CPA, cyproterone...

11β-hydroxylase (CYP11B1), 18-hydroxylase (aldosterone synthase, CYP11B2), and 3β-hydroxysteroid dehydrogenase (3β-HSD) to a lesser extent. In addition, mitotane has...

adrenal ferredoxin + O2 ⇌ {\displaystyle \rightleftharpoons } an 11beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O The 3 substrates of this enzyme...

biosynthesized from progesterone by the actions of 5β-reductase and 3β-hydroxysteroid dehydrogenase, with 5β-dihydroprogesterone as the intermediate in this...

PMID 29191401. S2CID 3705475. Chapman K, Holmes M, Seckl J (July 2013). "11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid...

Olivier NS, Patrito LC, Flury A (1989). "Regulation of the 3 beta-hydroxysteroid dehydrogenase activity in tissue fragments and microsomes from human...

pregn-4-en-3α-ol-20-one, is an endogenous neurosteroid. It is biosynthesized by 3α-hydroxysteroid dehydrogenase from progesterone. 3α-DHP has been found to act as a positive...

and Functional Aspects of Placental Lactogens (PLs) and Ovarian 20α-Hydroxysteroid Dehydrogenase (20α-HSD) in the Rat". Endocrine Journal. 41 (Supplement):...

a designer drug DOM-NBOMe 25G-NBOMe Trilostane, an inhibitor of 3 β-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome This set index...

Lima, P.H., Tarrant, A.M., Atkinson, M.J. and Atkinson, S. 2006. 17ß-Hydroxysteroid dehydrogenase (17ß-HSD) in scleractinian corals and zooxanthellae, Comparative...

metabolized by 5α- and 5β-reductases, 3α- and 3β-hydroxysteroid dehydrogenases, and 20α- and 20β-hydroxysteroid dehydrogenase in various tissues. In target...

17-β-Hydroxysteroid dehydrogenase X (HSD10) also known as 3-hydroxyacyl-CoA dehydrogenase type-2 is a mitochondrial enzyme that in humans is encoded by...

Jin Y, Penning TM (March 2001). "Steroid 5alpha-reductases and 3alpha-hydroxysteroid dehydrogenases: key enzymes in androgen metabolism". Best Practice &...

production of all steroid hormones from cholesterol [citation needed] 3β-Hydroxysteroid dehydrogenase 2 deficiency: impairs progestogen and androgen metabolism;...

and 3,4-didehydroretinol can act as competitive inhibitor of the 3α-hydroxysteroid dehydrogenase oxidative activity of the enzyme. This can potentially...

17β-Hydroxysteroid dehydrogenase type 14 also known as 17β-HSD type 14 or 17βHSD14 is an enzyme that in humans is encoded by the HSD17B14 gene. 17βHSD14...

progesterone, formed by the 20α-hydroxysteroid dehydrogenases (20α-HSDs) AKR1C1, AKR1C2, and AKR1C3 and the 17β-hydroxysteroid dehydrogenase (17β-HSD) HSD17B1...

liver. Estrone can also be reversibly converted into estradiol by 17β-hydroxysteroid dehydrogenases (17β-HSDs), and this accounts for most or all of its...

Linustedastat (developmental code names FOR-6219 and OG-6219) is a 17β-hydroxysteroid dehydrogenase 1 (17β-HSD1; HSD17B1) inhibitor which is under development...

Umbreit, W. W. (October 1975). "Enzymatic transformation of morphine by hydroxysteroid dehydrogenase from Pseudomonas testosteroni". Applied Microbiology....

C24 Cholane Bile acid C27 Cholestane Functional group 17-Ketosteroid Hydroxysteroid Halogenated steroid Elements removed Norsteroid Secosteroid Elements...

Fenofibrate/simvastatin, sold under the brand name Cholib, is a fixed-dose combination medication used to treat abnormal blood lipid levels when used in...

inhibits the conversion of inactive cortisone to cortisol by blocking 11β-hydroxysteroid dehydrogenase (11β-HSD). 11β-HSD also reversibly catalyzes the conversion...

deficiency, 17α-hydroxylase deficiency, 17,20-lyase deficiency, 3β-hydroxysteroid dehydrogenase deficiency, and cholesterol side-chain cleavage enzyme...

Acetoxolone (also known as acetylglycyrrhetic acid, acetylglycyrrhetinic acid, glycyrrhetinyl acetate and glycyrrhetic acid acetate) is a drug used for...

In enzymology, a 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) (EC 1.1.1.239) is an enzyme that catalyzes the chemical reaction: Testosterone + NAD+...

dehydrogenase (NADP+) EC 1.1.1.50: 3α-hydroxysteroid 3-dehydrogenase (Si-specific) EC 1.1.1.51: 3(or 17)β-hydroxysteroid dehydrogenase EC 1.1.1.52: 3α-hydroxycholanate...

tissues have all of the enzymes, including 3β-hydroxysteroid dehydrogenase (3β-HSD), 17β-hydroxysteroid dehydrogenase (17β-HSD), 5α-reductase, and steroid...

uterus. This is due to its inability to be inactivated by uterine 17β-hydroxysteroid dehydrogenase (17β-HSD). Because of its disproportionate effects in...

are required for placental-specific expression of the murine 3 beta-hydroxysteroid dehydrogenase VI gene, Hsd3b6". J. Biol. Chem. 277 (10): 7945–54. doi:10...

human endometrium and its disorders: a possible modulator of 17 beta-hydroxysteroid dehydrogenase". J. Clin. Endocrinol. Metab. 86 (6): 2721–7. doi:10.1210/jcem...

C24 Cholane Bile acid C27 Cholestane Functional group 17-Ketosteroid Hydroxysteroid Halogenated steroid Elements removed Norsteroid Secosteroid Elements...

Troglitazone is an antidiabetic and anti-inflammatory drug, and a member of the drug class of the thiazolidinediones. It was prescribed for people with...

Hippocampal Long-Term Potentiation and Spatial Learning in Aged 11β-Hydroxysteroid Dehydrogenase Type 1 Knock-Out Mice". The Journal of Neuroscience. 27...

mRNA has 2683 bp. The gene has these neighbors on chromosome 9: HSDL2: Hydroxysteroid dehydrogenase-like protein 2 plays a role in nucleotide binding, oxidoreductase...

an enzyme that in humans is encoded by the HSD17B7 gene. The 17-beta-hydroxysteroid dehydrogenase enzyme (EC 1.1.1.62) oxidizes or reduces estrogens and...

substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is...

Wood PJ, Pugh E, Webb RJ, Pellatt L and Mason HD (2013) Ovarian 11β-Hydroxysteroid Dehydrogenase (11βHSD) activity is suppressed in women with anovulatory...

C24 Cholane Bile acid C27 Cholestane Functional group 17-Ketosteroid Hydroxysteroid Halogenated steroid Elements removed Norsteroid Secosteroid Elements...

61: The reaction described is covered by EC 4.2.1.59. EC 4.2.1.62: 5α-hydroxysteroid dehydratase EC 4.2.1.63: Now known to comprise two enzymes, microsomal...

S synthetase 1 and Tyrocidine synthetase 1 respectively. baiA2 (3-ɑ-hydroxysteroid dehydrogenase): The next enzyme to act after baiB, baiA2 catalyzes the...

mechanisms include leptin, SOCS3, glucose transporter (GLUT)-4, POMC, 11-β-hydroxysteroid dehydrogenase type 2 and corticotrophin releasing hormone. Epigenetic...

Kaplan NO (1969). "Purification and substrate specificities of bacterial hydroxysteroid dehydrogenases". Biochemistry. 8 (12): 5093–103. doi:10.1021/bi00840a063...

It can inhibit enzymes related to steroid metabolism, such as 11β-hydroxysteroid dehydrogenase, although this effect is still under further investigation...

S2CID 13428727. van Uum SH, Lenders JW, Hermus AR (May 2004). "Cortisol, 11beta-hydroxysteroid dehydrogenases, and hypertension". Semin Vasc Med. 4 (2): 121–8. doi:10...

topically because the skin lacks the necessary activating enzyme 11β-Hydroxysteroid dehydrogenase. Systemically, this agent's activity on glucocorticoid...

USAN, BAN) (developmental code name WIN-32729) is an inhibitor of 3β-hydroxysteroid dehydrogenase (3β-HSD) that was developed as a contraceptive, abortifacient...

including ethanol (beverage alcohol), retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting...

cortisone in the kidneys. This occurs via inhibition of the enzyme 11-β-hydroxysteroid dehydrogenase.[citation needed] As a result, cortisol levels become...

3α-Hydroxytibolone is formed by 3α-hydroxysteroid dehydrogenase, 3β-hydroxytibolone is formed by 3β-hydroxysteroid dehydrogenase, δ4-tibolone is formed...

characterization revealed it is composed of two proteinaceous sub-units: the 3beta-hydroxysteroid delta8-delta7-isomerase (D8D7I), also known as the emopamil binding...

substrate of this E. crepidifolium enzyme has not yet been identified. 3β-Hydroxysteroid dehydrogenases represent another enzyme class that is predicted to be...

two steroids in various tissues. Estrone can also be converted by 17β-hydroxysteroid dehydrogenases into the more potent estrogen estradiol. E1S levels are...

open reading frame 54, also known as HSD-29 (hydroxysteroid 29 dehydrogenase) and HSD-30 (hydroxysteroid 30 dehydrogenase) is a protein coding gene. The...

half-maximal inhibitory concentration = 8.5 nM), but also 3β-HSDTooltip 3β-hydroxysteroid dehydrogenase inhibitor, investigated extensively but found to be hepatotoxic...

hydroxylase deficiency 11 beta hydroxysteroid dehydrogenase type 2 deficiency 17 alpha hydroxylase deficiency 17-beta-hydroxysteroid dehydrogenase deficiency...

Monder C, New MI, White PC (September 1991). "The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization"...

receptor homologue-1, in the regulation of human corpus luteum 3beta-hydroxysteroid dehydrogenase type II". The Journal of Clinical Endocrinology and Metabolism...

5α-pregnane-3α,17α-diol-20-one (5α-Pdiol) via 3α-reduction by a 3α-hydroxysteroid dehydrogenase isozyme (AKR1C2 and AKR1C4) or HSD17B6, that also has...

Analogously to the reversible transformation of estrone into estradiol by 17β-hydroxysteroid dehydrogenase, equilin can be converted into the more potent estrogen...

(July 2009). "KLF15 Is a transcriptional regulator of the human 17beta-hydroxysteroid dehydrogenase type 5 gene. A potential link between regulation of testosterone...

Bujalska IJ, et al. (2003). "Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to...

Pharmacophore Modeling and Virtual Screening for the Discovery of Novel 17β-Hydroxysteroid Dehydrogenase 2 Inhibitors". Journal of Medicinal Chemistry. 57 (14):...

et al. (1998). "The identification of 5 alpha-reductase-2 and 17 beta-hydroxysteroid dehydrogenase-3 gene defects in male pseudohermaphrodites from a Turkish...

mineralocorticoid excess syndrome, involves a defect in the gene for 11β-hydroxysteroid dehydrogenase, an enzyme that normally inactivates circulating cortisol...

Pangborn W (October 1994). "Mechanism of inhibition of 3 alpha, 20 beta-hydroxysteroid dehydrogenase by a licorice-derived steroidal inhibitor". Structure...

20-lyase deficiency Combined 17α-hydroxylase/17,20-lyase deficiency 17β-Hydroxysteroid dehydrogenase III deficiency Androgen insensitivity syndrome "OMIM Entry...

double bond already present. Other research indicates that 3[beta]-hydroxysteroid dehydrogenase (3[beta]-HSD) plays a vital role in the metabolism of...

discovered via the observation that it induced the synthesis of 20alpha-hydroxysteroid dehydrogenase in hematopoietic cells and termed it interleukin-3 (IL-3)...

Steroidogenesis, showing many of the enzyme activities that are performed by cytochrome P450 enzymes. HSD: Hydroxysteroid dehydrogenase....

Those assigned female at birth with 5-alpha-reductase deficiency or 17-hydroxysteroid dehydrogenase deficiency have a high prevalence of gender dysphoria...

to and acts as a potent, selective, and irreversible inhibitor of 3β-hydroxysteroid dehydrogenase (3β-HSD), an enzyme that is responsible for the conversion...

and 11β-hydroxyprogesterone are known to be potent inhibitors of 11β-hydroxysteroid dehydrogenase (11β-HSD), which is responsible for the biosynthesis of...

syndrome, Early-onset sarcoidosis NOTCH3 CADASIL syndrome NSDHL 3-beta-hydroxysteroid dehydrogenase CHILD syndrome OCA2 (P) P protein Oculocutaneous albinism...

(2012). "The anabolic androgenic steroid fluoxymesterone inhibits 11β-hydroxysteroid dehydrogenase 2-dependent glucocorticoid inactivation". Toxicol. Sci...

hexyl-malonyl-ACP. The β-lactone ring is formed by reduction of 3-keto group by 3-hydroxysteroid dehydrogenase homologue followed by a spontaneously nucleophilic attack...

a Zuni girl. Her team was the first to publish mutations on the 11β-hydroxysteroid dehydrogenase type 2 enzyme (encoded by the HSD11B2 gene) causing this...

A, Okinaga S, Arai K (June 1989). "Inhibition of rat ovarian 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD), 17 alpha-hydroxylase and 17,20 lyase by...

C24 Cholane Bile acid C27 Cholestane Functional group 17-Ketosteroid Hydroxysteroid Halogenated steroid Elements removed Norsteroid Secosteroid Elements...

able to authorize the sterilization of their 5-year child with 17-beta-hydroxysteroid dehydrogenase III deficiency. The child had previously been subjected...

(HPA) axis response to stress. Increased methylation in the 11β-hydroxysteroid dehydrogenase type 2 (HSD2), glucocorticoid receptor (GR), and H19 ICR...

bioavailability. List of androgen esters § Dihydrotestosterone esters 3α-Hydroxysteroid dehydrogenase Gooren LJ, van der Veen EA, van Kessel H, Harmsen-Louman...

Spironolactone has been found to act as a reversible inhibitor of human 17β-hydroxysteroid dehydrogenase 2 (17β-HSD2), albeit with weak potency (Ki = 0.25–2.4 μM;...

(December 2016). "46,XY disorder of sex development due to 17-beta hydroxysteroid dehydrogenase type 3 deficiency: a plea for timely genetic testing"...

20-lyase inhibit the synthesis of androgens and therefore estrogens 3β-Hydroxysteroid dehydrogenase inhibitors 3β-HSD inhibit the synthesis of progestogens...

pancreatic islets-stress axis by hypothalamic releasing hormones and 11beta-hydroxysteroid dehydrogenase". Proceedings of the National Academy of Sciences of the...

side-chain cleavage enzyme, 3β-hydroxysteroid dehydrogenase/Δ5-4 isomerase, 17α-hydroxylase, 17,20-lyase, 17β-hydroxysteroid dehydrogenase, 21-hydroxylase...

20-lyase deficiency Combined 17α-hydroxylase/17,20-lyase deficiency 17β-Hydroxysteroid dehydrogenase III deficiency Aromatase deficiency and estrogen insensitivity...

C24 Cholane Bile acid C27 Cholestane Functional group 17-Ketosteroid Hydroxysteroid Halogenated steroid Elements removed Norsteroid Secosteroid Elements...

multiple-malformation/mental retardation syndrome due to deficiency of 3beta-hydroxysteroid-delta5-desaturase". Am. J. Hum. Genet. 71 (4): 952–8. doi:10.1086/342668...

Cornell University Medical College, first to publish mutations on the 11β-hydroxysteroid dehydrogenase type 2 enzyme Alton Sutnick, Class of 1954: made the seminal...

"Expression and NNK reducing activities of carbonyl reductase and 11beta-hydroxysteroid dehydrogenase type 1 in human lung". Chemico-Biological Interactions...

Grzeschik KH (Apr 2000). "Mutations in the NSDHL gene, encoding a 3beta-hydroxysteroid dehydrogenase, cause CHILD syndrome". Am J Med Genet. 90 (4): 339–46...

C24 Cholane Bile acid C27 Cholestane Functional group 17-Ketosteroid Hydroxysteroid Halogenated steroid Elements removed Norsteroid Secosteroid Elements...

which express both the mineralocorticoid receptor (MR) and 11-beta-hydroxysteroid dehydrogenase type 2 (HSD2). HSD2 is an enzyme that metabolizes cortisol...

21-hydroxylase deficiency Congenital adrenal hyperplasia due to 3 beta-hydroxysteroid dehydrogenase deficiency Congenital adrenal hyperplasia, lipoid Congenital...

C24 Cholane Bile acid C27 Cholestane Functional group 17-Ketosteroid Hydroxysteroid Halogenated steroid Elements removed Norsteroid Secosteroid Elements...

Cheng C, Xu M, Zhou Z, Ying K, Xi Y, Mao Y (2002). "A novel human hydroxysteroid dehydrogenase like 1 gene (HSDL1) is highly expressed in reproductive...

dehydrogenases/reductases in the oxidation and epimerization of 3alpha-hydroxysteroids in human tissues". Endocrinology. 148 (5): 2148–56. doi:10.1210/en...

cortisol and corticosterone production by weakly inhibiting the enzymes 3β-hydroxysteroid dehydrogenase and 21-hydroxylase. These are antiglucocorticoid actions...

C24 Cholane Bile acid C27 Cholestane Functional group 17-Ketosteroid Hydroxysteroid Halogenated steroid Elements removed Norsteroid Secosteroid Elements...

PMID 10904013. Ferrari P, Krozowski Z (April 2000). "Role of the 11beta-hydroxysteroid dehydrogenase type 2 in blood pressure regulation". Kidney International...

addition, it is categorized as C3 (AKR1C3) because it is an isoform of 3α-hydroxysteroid dehydrogenase. The function of PGFS is to catalyze the reduction of...

Da Cunha T, et al. (February 2009). "Selective inhibition of 11beta-hydroxysteroid dehydrogenase 1 by 18alpha-glycyrrhetinic acid but not 18beta-glycyrrhetinic...

O2 oxidoreductase, 3beta-hydroxy steroid oxidoreductase, and 3beta-hydroxysteroid:oxygen oxidoreductase. This enzyme participates in bile acid biosynthesis...

K, Lübbert H, Pollow B (January 1976). "On the mitochondrial 17beta-hydroxysteroid dehydrogenase from human endometrium and endometrial carcinoma: characterization...

17-alpha-hydroxylase/17,20-lyase deficiency; 202110; CYP17A1 17-beta-hydroxysteroid dehydrogenase X deficiency; 300438; HSD17B10 2-methylbutyrylglycinuria;...

that in humans is encoded by the HSD17B12 gene. The enzyme 17-beta hydroxysteroid dehydrogenase-12 (HSD17B12) uses NADPH to reduce 3-ketoacyl-CoA to 3-hydroxyacyl-CoA...

that E2MATE, without being hydrolyzed first, can be converted by 17β-hydroxysteroid dehydrogenase into estrone sulfamate (EMATE), analogously to the conversion...

metabolite of abiraterone acetate). D4A is formed from abiraterone by 3β-hydroxysteroid dehydrogenase/Δ5-4 isomerase (3β-HSD). It is said to be a more potent...

noticed a defect in 21-hydroxylation in CAH, followed by defects in 3β-hydroxysteroid dehydrogenase and 11β-hydroxylase. P450 enzymes were described from...

11β-hydroxylase, 17α-hydroxylase, 17,20-lyase, 21-hydroxylase, and 3β-hydroxysteroid dehydrogenase, as well as of cholesterol side-chain cleavage enzyme...

7alpha-hydroxylation in human tissues: possible interference with type 1 11beta-hydroxysteroid dehydrogenase-mediated processes". J. Steroid Biochem. Mol. Biol. 104...

C24 Cholane Bile acid C27 Cholestane Functional group 17-Ketosteroid Hydroxysteroid Halogenated steroid Elements removed Norsteroid Secosteroid Elements...

multiple-malformation/mental retardation syndrome due to deficiency of beta-hydroxysteroid-delta 5-desaturase". The American Journal of Human Genetics. 71 (4):...

the lumen of endoplasmic reticulum using N-terminal domains of 11beta-hydroxysteroid dehydrogenase and the 50-kDa esterase". J. Biol. Chem. 274 (20): 14122–9...

Hara A, Nakagawa M, Taniguchi H, Sawada H (November 1989). "3(20)α-Hydroxysteroid Dehydrogenase Activity of Monkey Liver Indanol Dehydrogenase". J. Biochem...

disorders with mutations lowering the activity of the enzyme 11-beta-hydroxysteroid dehydrogenase type 2 (11-β-HSD2). These mutations limit the ability...

Δ5-Δ4-isomerase. Other names in common use include ketosteroid isomerase (KSI), hydroxysteroid isomerase, steroid isomerase, Δ5-ketosteroid isomerase, Δ5(or Δ4)-3-keto...

C24 Cholane Bile acid C27 Cholestane Functional group 17-Ketosteroid Hydroxysteroid Halogenated steroid Elements removed Norsteroid Secosteroid Elements...

Hansson V (August 1981). "Kinetic properties of the soluble 3 alpha-hydroxysteroid dehydrogenase from rat testis and epididymis". Journal of Steroid Biochemistry...

very potent competitive inhibitor of both isoforms (1 and 2) of 11β-hydroxysteroid dehydrogenase (11β-HSD). The steroid 11β-OHP has been known since 1987...

doi:10.1016/S0031-9422(97)00315-4. Warneck HM, Seitz HU (1990). "3 beta-hydroxysteroid oxidoreductase in suspension cultures of Digitalis lanata EHRH". Z....

Jakoby WB (July 1980). "The identity of alcohol sulfotransferases with hydroxysteroid sulfotransferases". Arch. Biochem. Biophys. 202 (2): 474–81. doi:10...

rooibos may have beneficial effects on prostate cancer by inhibiting 17β-Hydroxysteroid dehydrogenases and blocking dihydrotestosterone. Her research is also...

C24 Cholane Bile acid C27 Cholestane Functional group 17-Ketosteroid Hydroxysteroid Halogenated steroid Elements removed Norsteroid Secosteroid Elements...

reductase MeSH D08.811.682.047.436 – hydroxysteroid dehydrogenases MeSH D08.811.682.047.436.174 – 11-beta-hydroxysteroid dehydrogenases MeSH D08.811.682.047...

into an inactive metabolite (11-keto products), called Placental 11 β-hydroxysteroid-dehydrogenase. The problem lies in the multiplying factor arising from...

reductive 3α-hydroxysteroid dehydrogenase (3α-HSD), i.e. by the two aldo-keto reductase isozymes: AKR1C2 and AKR1C4, and by 17β-hydroxysteroid dehydrogenase...

Saffery R, Fuller P, Enriquez C, Krozowski Z (May 2003). "17 beta-hydroxysteroid dehydrogenase type XI localizes to human steroidogenic cells". Endocrinology...

11-ketoprogesterone is reported to act as an inhibitor of the enzyme 11β-hydroxysteroid dehydrogenase. It has also been found to act as a weak negative allosteric...

2001). "Characterization of a novel type of human microsomal 3alpha -hydroxysteroid dehydrogenase: unique tissue distribution and catalytic properties"...