Alcohol dehydrogenase 6 is an enzyme that in humans is encoded by the ADH6gene.[3][4]
This gene encodes class V alcohol dehydrogenase, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This gene is expressed in the stomach as well as in the liver, and it contains a glucocorticoid response element upstream of its 5' UTR, which is a steroidhormone receptor binding site. The deduced amino acid sequence of the open reading frame of this gene shows about 60% positional identity with other known alcohol dehydrogenases. This gene may have a distinct physiologic function.[4]
Yoshida A (1995). "Genetic polymorphisms of alcohol metabolizing enzymes related to alcohol sensitivity and alcoholic diseases". Alcohol Alcohol. 29 (6): 693–6. PMID7695785.
Chen CS, Yoshida A (1992). "Enzymatic properties of the protein encoded by newly cloned human alcohol dehydrogenase ADH6 gene". Biochem. Biophys. Res. Commun. 181 (2): 743–7. doi:10.1016/0006-291X(91)91253-9. PMID1755855.
Zhi X, Chan EM, Edenberg HJ (2000). "Tissue-specific regulatory elements in the human alcohol dehydrogenase 6 gene". DNA Cell Biol. 19 (8): 487–97. doi:10.1089/10445490050128412. PMID10975466.
Strömberg P, Höög JO (2001). "Human class V alcohol dehydrogenase (ADH5): A complex transcription unit generates C-terminal multiplicity". Biochem. Biophys. Res. Commun. 278 (3): 544–9. doi:10.1006/bbrc.2000.3837. PMID11095947.
Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.
The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.
