Handleyomys is a genus of Central and South Americanrodents in the tribe Oryzomyini of family Cricetidae. It was first described in 2002 to include two species from the ColombianAndes which were previously included in distinct and unrelated genera, Aepeomys and Oryzomys, but which turned out to be closely related. Later, in 2006, six other species were provisionally added from Oryzomys; these are expected to be placed in new genera in the future.