Glycerol-3-phosphate dehydrogenase (quinone)

Glycerol-3-phosphate dehydrogenase
Glycerol-3-phosphate dehydrogenase monomer + FAD, E.Coli
Identifiers
EC no.	1.1.5.3
CAS no.	9001-49-4
Alt. names	valpha-glycerophosphate dehydrogenase, alpha-glycerophosphate dehydrogenase (acceptor), anaerobic glycerol-3-phosphate dehydrogenase, DL-glycerol 3-phosphate oxidase (misleading), FAD-dependent glycerol-3-phosphate dehydrogenase, FAD-dependent sn-glycerol-3-phosphate dehydrogenase, FAD-GPDH, FAD-linked glycerol 3-phosphate dehydrogenase, FAD-linked L-glycerol-3-phosphate dehydrogenase, flavin-linked glycerol-3-phosphate dehydrogenase, flavoprotein-linked L-glycerol 3-phosphate dehydrogenase, glycerol 3-phosphate cytochrome c reductase (misleading), glycerol phosphate dehydrogenase, glycerol phosphate dehydrogenase (acceptor), glycerol phosphate dehydrogenase (FAD), glycerol-3-phosphate CoQ reductase, glycerol-3-phosphate dehydrogenase (flavin-linked), glycerol-3-phosphate:CoQ reductase, glycerophosphate dehydrogenase, L-3-glycerophosphate-ubiquinone oxidoreductase, L-glycerol-3-phosphate dehydrogenase (ambiguous), L-glycerophosphate dehydrogenase, mGPD, mitochondrial glycerol phosphate dehydrogenase, NAD+-independent glycerol phosphate dehydrogenase, pyridine nucleotide-independent L-glycerol 3-phosphate dehydrogenase, sn-glycerol 3-phosphate oxidase (misleading), sn-glycerol-3-phosphate dehydrogenase, sn-glycerol-3-phosphate:(acceptor) 2-oxidoreductase, sn-glycerol-3-phosphate:acceptor 2-oxidoreductase)
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3 is an enzyme with systematic name sn-glycerol 3-phosphate:quinone oxidoreductase.^{[1][2][3][4][5][6][7][8]} This enzyme catalyses the following chemical reaction

sn-glycerol 3-phosphate + quinone ${\displaystyle \rightleftharpoons }$ glycerone phosphate + quinol

This flavin-dependent dehydrogenase is a membrane enzyme. It participates in glycolysis, respiration and phospholipid biosynthesis.

References

1. Ringler RL (April 1961). "Studies on the mitochondrial alpha-glycerophosphate dehydrogenase. II. Extraction and partial purification of the dehydrogenase from pig brain". The Journal of Biological Chemistry. 236 (4): 1192–8. doi:10.1016/S0021-9258(18)64266-8. PMID 13741763.
2. Schryvers A, Lohmeier E, Weiner JH (February 1978). "Chemical and functional properties of the native and reconstituted forms of the membrane-bound, aerobic glycerol-3-phosphate dehydrogenase of Escherichia coli". The Journal of Biological Chemistry. 253 (3): 783–8. doi:10.1016/S0021-9258(17)38171-1. PMID 340460.
3. MacDonald MJ, Brown LJ (February 1996). "Calcium activation of mitochondrial glycerol phosphate dehydrogenase restudied". Archives of Biochemistry and Biophysics. 326 (1): 79–84. doi:10.1006/abbi.1996.0049. PMID 8579375.
4. Rauchová H, Fato R, Drahota Z, Lenaz G (August 1997). "Steady-state kinetics of reduction of coenzyme Q analogs by glycerol-3-phosphate dehydrogenase in brown adipose tissue mitochondria". Archives of Biochemistry and Biophysics. 344 (1): 235–41. doi:10.1006/abbi.1997.0150. PMID 9244403.
5. Shen W, Wei Y, Dauk M, Zheng Z, Zou J (February 2003). "Identification of a mitochondrial glycerol-3-phosphate dehydrogenase from Arabidopsis thaliana: evidence for a mitochondrial glycerol-3-phosphate shuttle in plants". FEBS Letters. 536 (1–3): 92–6. Bibcode:2003FEBSL.536...92S. doi:10.1016/s0014-5793(03)00033-4. PMID 12586344.
6. Walz AC, Demel RA, de Kruijff B, Mutzel R (July 2002). "Aerobic sn-glycerol-3-phosphate dehydrogenase from Escherichia coli binds to the cytoplasmic membrane through an amphipathic alpha-helix". The Biochemical Journal. 365 (Pt 2): 471–9. doi:10.1042/BJ20011853. PMC 1222694. PMID 11955283.
7. Ansell R, Granath K, Hohmann S, Thevelein JM, Adler L (May 1997). "The two isoenzymes for yeast NAD+-dependent glycerol 3-phosphate dehydrogenase encoded by GPD1 and GPD2 have distinct roles in osmoadaptation and redox regulation". The EMBO Journal. 16 (9): 2179–87. doi:10.1093/emboj/16.9.2179. PMC 1169820. PMID 9171333.
8. Larsson C, Påhlman IL, Ansell R, Rigoulet M, Adler L, Gustafsson L (March 1998). "The importance of the glycerol 3-phosphate shuttle during aerobic growth of Saccharomyces cerevisiae". Yeast. 14 (4): 347–57. doi:10.1002/(SICI)1097-0061(19980315)14:4<347::AID-YEA226>3.0.CO;2-9. PMID 9559543.

External links

• Glycerol-3-phosphate+dehydrogenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)