Geranyl diphosphate 2-C-methyltransferase

Geranyl diphosphate 2-C-methyltransferase
Identifiers
EC no.	2.1.1.255
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Geranyl diphosphate 2-C-methyltransferase (EC 2.1.1.255, SCO7701, GPP methyltransferase, GPPMT, 2-methyl-GPP synthase, MGPPS, geranyl pyrophosphate methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:geranyl-diphosphate 2-C-methyltransferase.^[1][2][3][4] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + geranyl diphosphate ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate

This enzyme takes part in synthesis of 2-methylisoborneol.

References

1. Wang CM, Cane DE (July 2008). "Biochemistry and molecular genetics of the biosynthesis of the earthy odorant methylisoborneol in Streptomyces coelicolor". Journal of the American Chemical Society. 130 (28): 8908–9. doi:10.1021/ja803639g. PMC 3023297. PMID 18563898.
2. Ariyawutthiphan O, Ose T, Tsuda M, Gao Y, Yao M, Minami A, Oikawa H, Tanaka I (March 2011). "Crystallization and preliminary X-ray crystallographic study of a methyltransferase involved in 2-methylisoborneol biosynthesis in Streptomyces lasaliensis". Acta Crystallographica Section F. 67 (Pt 3): 417–20. doi:10.1107/s1744309110051523. PMC 3053176. PMID 21393856.
3. Komatsu M, Tsuda M, Omura S, Oikawa H, Ikeda H (May 2008). "Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol". Proceedings of the National Academy of Sciences of the United States of America. 105 (21): 7422–7. doi:10.1073/pnas.0802312105. PMC 2387273. PMID 18492804.
4. Giglio S, Chou WK, Ikeda H, Cane DE, Monis PT (February 2011). "Biosynthesis of 2-methylisoborneol in cyanobacteria". Environmental Science & Technology. 45 (3): 992–8. doi:10.1021/es102992p. PMC 3699865. PMID 21174459.

External links

• Geranyl+diphosphate+2-C-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)