Diethyl 2-methyl-3-oxosuccinate reductase

diethyl 2-methyl-3-oxosuccinate reductase
Identifiers
EC no.	1.1.1.229
CAS no.	110369-21-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a diethyl 2-methyl-3-oxosuccinate reductase (EC 1.1.1.229) is an enzyme that catalyzes the chemical reaction

diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP⁺ ${\displaystyle \rightleftharpoons }$ diethyl 2-methyl-3-oxosuccinate + NADPH + H⁺

Thus, the two substrates of this enzyme are diethyl (2R,3R)-2-methyl-3-hydroxysuccinate and NADP⁺, whereas its 3 products are diethyl 2-methyl-3-oxosuccinate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is diethyl-(2R,3R)-2-methyl-3-hydroxysuccinate:NADP⁺ 3-oxidoreductase.

References

• Furuichi A, Akita H, Matsukura H, Oishi T, Horikoshi K (1987). "Purification and properties of an asymmetric reduction of diethyl 2-methyl-3-oxosuccinate in Saccharomyces fermentati". Agric. Biol. Chem. 51 (2): 293–299. doi:10.1271/bbb1961.51.293.