DATP(dGTP)—DNA purinetransferase

dATP(dGTP)—DNA purinetransferase
Identifiers
EC no.	2.6.99.1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

dATP(dGTP)—DNA purinetransferase (EC 2.6.99.1) is an enzyme with systematic name dATP(dGTP):depurinated-DNA purine transferase.^[1][2] This enzyme catalyses the following chemical reaction

(1) dATP + depurinated DNA ${\displaystyle \rightleftharpoons }$ deoxyribose triphosphate + DNA

(2) dGTP + depurinated DNA ${\displaystyle \rightleftharpoons }$ deoxyribose triphosphate + DNA

The purine residue is transferred on to the apurinic site forming a normal glycosylic bond.

References

1. Deutsch WA, Linn S (January 1979). "DNA binding activity from cultured human fibrolasts that is specific for partially depurinated DNA and that inserts purines into apurinic sites". Proceedings of the National Academy of Sciences of the United States of America. 76 (1): 141–4. Bibcode:1979PNAS...76..141D. doi:10.1073/pnas.76.1.141. PMC 382892. PMID 218192.
2. Livneh Z, Elad D, Sperling J (March 1979). "Enzymatic insertion of purine bases into depurinated DNA in vitro". Proceedings of the National Academy of Sciences of the United States of America. 76 (3): 1089–93. Bibcode:1979PNAS...76.1089L. doi:10.1073/pnas.76.3.1089. PMC 383194. PMID 375225.

External links

• DATP(dGTP)---DNA+purinetransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)