C-terminal processing peptidase

C-terminal processing peptidase
Identifiers
EC no.	3.4.21.102
CAS no.	92480-11-0&title= 216484-75-2, 92480-11-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

C-terminal processing peptidase (EC 3.4.21.102, CtpA gene product (Synechocystis sp.), photosystem II D1 protein processing peptidase, protease Re, tail-specific protease, Tsp protease) is an enzyme.^[1][2][3] This enzyme catalyses the following chemical reaction

The enzyme shows specific recognition of a C-terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala, but then cleaves at a variable distance from the C-terminus. A typical cleavage is -Ala-Ala!Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala. In the plant chloroplast, the enzyme removes the C-terminal extension of the X1 polypeptide of photosystem II

Proteolytic processing of the X1 protein of photosystem II enables light-driven assembly of the tetranuclear manganese cluster.

See also

• D1 protein, also known as PsbA

References

1. Keiler KC, Sauer RT (1998). "Tsp protease". In Barrett AJ, Rawlings ND, Woessner JF (eds.). Handbook of Proteolytic Enzymes. London: Handbook of Proteolytic Enzymes. pp. 460–461.
2. Beebe KD, Shin J, Peng J, Chaudhury C, Khera J, Pei D (March 2000). "Substrate recognition through a PDZ domain in tail-specific protease". Biochemistry. 39 (11): 3149–55. doi:10.1021/bi992709s. PMID 10715137.
3. Liao DI, Qian J, Chisholm DA, Jordan DB, Diner BA (September 2000). "Crystal structures of the photosystem II D1 C-terminal processing protease". Nature Structural Biology. 7 (9): 749–53. doi:10.1038/78973. PMID 10966643.

External links

• C-terminal+processing+peptidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)