Aphidicolan-16beta-ol synthase

Aphidicolan-16β-ol synthase
Identifiers
EC no.	4.2.3.42
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Aphidicolan-16β-ol synthase (EC 4.2.3.42, PbACS) is an enzyme with systematic name 9α-copalyl-diphosphate diphosphate-lyase (aphidicolan-16β-ol-forming).^[1][2] This enzyme catalyses the following chemical reaction

9α-copalyl diphosphate + H₂O ${\displaystyle \rightleftharpoons }$ aphidicolan-16β-ol + diphosphate

This is a bifunctional enzyme, which also has EC 5.5.1.14 activity.

References

1. Oikawa H, Toyomasu T, Toshima H, Ohashi S, Kawaide H, Kamiya Y, Ohtsuka M, Shinoda S, Mitsuhashi W, Sassa T (May 2001). "Cloning and functional expression of cDNA encoding aphidicolan-16 β-ol synthase: a key enzyme responsible for formation of an unusual diterpene skeleton in biosynthesis of aphidicolin". Journal of the American Chemical Society. 123 (21): 5154–5. doi:10.1021/ja015747j. PMID 11457369.
2. Toyomasu T, Nakaminami K, Toshima H, Mie T, Watanabe K, Ito H, Matsui H, Mitsuhashi W, Sassa T, Oikawa H (January 2004). "Cloning of a gene cluster responsible for the biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase α". Bioscience, Biotechnology, and Biochemistry. 68 (1): 146–52. doi:10.1271/bbb.68.146. PMID 14745177.

External links

• Aphidicolan-16beta-ol+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)