ADAM18

ADAM18
Identifiers
Aliases	ADAM18, ADAM27, tMDCIII, ADAM metallopeptidase domain 18
External IDs	MGI: 105986; HomoloGene: 74941; GeneCards: ADAM18; OMA:ADAM18 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p11.22 Start 39,584,489 bp[1] End 39,730,065 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A2 Start 25,092,262 bp[2] End 25,164,771 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle left testis right testis testicle gonad monocyte right coronary artery apex of heart left ventricle urinary bladder Top expressed in spermatocyte spermatid seminiferous tubule visual cortex primary visual cortex superior frontal gyrus islet of Langerhans somite More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metalloendopeptidase activity metallopeptidase activity Cellular component integral component of membrane membrane Biological process multicellular organism development cell differentiation spermatogenesis proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8749 13524 Ensembl ENSG00000168619 ENSG00000278548 ENSMUSG00000031552 UniProt Q9Y3Q7 Q9R157 RefSeq (mRNA) NM_001190956 NM_014237 NM_001320313 NM_010084 RefSeq (protein) NP_001177885 NP_001307242 NP_055052 NP_034214 Location (UCSC) Chr 8: 39.58 – 39.73 Mb Chr 8: 25.09 – 25.16 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Disintegrin and metalloproteinase domain-containing protein 18 is an enzyme that in humans is encoded by the ADAM18 gene.^[5][6]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a sperm surface protein.^[6]

References

1. ENSG00000278548 GRCh38: Ensembl release 89: ENSG00000168619, ENSG00000278548 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031552 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Frayne J, Hurd EA, Hall L (Aug 2002). "Human tMDC III: a sperm protein with a potential role in oocyte recognition". Mol Hum Reprod. 8 (9): 817–22. doi:10.1093/molehr/8.9.817. PMID 12200459.
6. "Entrez Gene: ADAM18 ADAM metallopeptidase domain 18".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhu GZ, Lin Y, Myles DG, Primakoff P (1999). "Identification of four novel ADAMs with potential roles in spermatogenesis and fertilization". Gene. 234 (2): 227–37. doi:10.1016/S0378-1119(99)00208-5. PMID 10395895.
• Frayne J, Jury JA, Barker HL, et al. (1998). "Macaque MDC family of proteins: sequence analysis, tissue distribution and processing in the male reproductive tract". Mol. Hum. Reprod. 4 (5): 429–37. doi:10.1093/molehr/4.5.429. PMID 9665629.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

External links

• The MEROPS online database for peptidases and their inhibitors: M12.957
• Human ADAM18 genome location and ADAM18 gene details page in the UCSC Genome Browser.