4-chlorobenzoate dehalogenase

4-chlorobenzoate dehalogenase
Identifiers
EC no.	3.8.1.6
CAS no.	94047-11-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a 4-chlorobenzoate dehalogenase (EC 3.8.1.6) is an enzyme that catalyzes the chemical reaction

4-chlorobenzoate + H₂O ${\displaystyle \rightleftharpoons }$ 4-hydroxybenzoate + chloride

Thus, the two substrates of this enzyme are 4-chlorobenzoate and H₂O, whereas its two products are 4-hydroxybenzoate and chloride.

This enzyme belongs to the family of hydrolases, specifically those acting on halide bonds in carbon-halide compounds. The systematic name of this enzyme class is 4-chlorobenzoate chlorohydrolase. This enzyme is also called halobenzoate dehalogenase.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1BVQ, 1JXZ, and 1NZY.

References

• Müller R, Thiele J, Klages U, Lingens F (October 1984). "Incorporation of [18O]water into 4-hydroxybenzoic acid in the reaction of 4-chlorobenzoate dehalogenase from pseudomonas spec. CBS 3". Biochemical and Biophysical Research Communications. 124 (1): 178–82. doi:10.1016/0006-291X(84)90933-1. PMID 6497878.
• Heppel LA, Porterfield VT (November 1948). "Enzymatic dehalogenation of certain brominated and chlorinated compounds". The Journal of Biological Chemistry. 176 (2): 763–9. doi:10.1016/S0021-9258(19)52691-6. PMID 18889931.