3-deoxyoctulosonase

3-deoxyoctulosonase
Identifiers
EC no.	3.2.1.144
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a 3-deoxyoctulosonase (EC 3.2.1.144) is an enzyme that catalyzes the chemical reaction

3-deoxyoctulosonyl-lipopolysaccharide + H₂O ${\displaystyle \rightleftharpoons }$ 3-deoxyoctulosonic acid + lipopolysaccharide

Thus, the two substrates of this enzyme are 3-deoxyoctulosonyl-lipopolysaccharide and H₂O, whereas its two products are 3-deoxyoctulosonic acid and lipopolysaccharide.

This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is 3-deoxyoctulosonyl-lipopolysaccharide hydrolase. This enzyme is also called alpha-Kdo-ase.

References

• Li YT, Wang LX, Pavlova NV, Li SC, Lee YC (October 1997). "alpha-KDOase activity in oyster and synthesis of alpha- and beta-4-methylumbelliferyl ketosides of 3-deoxy-D-manno-octulosonic acid". The Journal of Biological Chemistry. 272 (42): 26419–24. doi:10.1074/jbc.272.42.26419. PMID 9334217.