23S rRNA (adenosine1067-2'-O)-methyltransferase

23S rRNA (adenosine^1067-2'-O)-methyltransferase
Identifiers
EC no.	2.1.1.230
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

23S rRNA (adenosine¹⁰⁶⁷-2'-O)-methyltransferase (EC 2.1.1.230, 23S rRNA A1067 2'-methyltransferase, thiostrepton-resistance methylase, nosiheptide-resistance methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (adenosine¹⁰⁶⁷-2'-O)-methyltransferase.^[1][2][3][4] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + adenosine¹⁰⁶⁷ in 23S rRNA ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + 2'-O-methyladenosine¹⁰⁶⁷ in 23S rRNA

The methylase that is responsible for autoimmunity in the thiostrepton producer Streptomyces azureus.

References

1. Bechthold A, Floss HG (September 1994). "Overexpression of the thiostrepton-resistance gene from Streptomyces azureus in Escherichia coli and characterization of recognition sites of the 23S rRNA A1067 2'-methyltransferase in the guanosine triphosphatase center of 23S ribosomal RNA". European Journal of Biochemistry. 224 (2): 431–7. doi:10.1111/j.1432-1033.1994.00431.x. PMID 7925357.
2. Thompson J, Schmidt F, Cundliffe E (July 1982). "Site of action of a ribosomal RNA methylase conferring resistance to thiostrepton". The Journal of Biological Chemistry. 257 (14): 7915–7. PMID 6806287.
3. Thompson, J.; Cundliffe, E. (1981). "Purification and properties of an RNA methylase produced by Streptomyces azureus and involved in resistance to thiostrepton". J. Gen. Microbiol. 124: 291–297. doi:10.1099/00221287-124-2-291.
4. Yang H, Wang Z, Shen Y, Wang P, Jia X, Zhao L, Zhou P, Gong R, Li Z, Yang Y, Chen D, Murchie AI, Xu Y (August 2010). "Crystal structure of the nosiheptide-resistance methyltransferase of Streptomyces actuosus". Biochemistry. 49 (30): 6440–50. doi:10.1021/bi1005915. PMID 20550164.

External links

• 23S+rRNA+(adenosine1067-2'-O)-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)