Defending champions Nikola Mektić and Mate Pavić defeated John Isner and Diego Schwartzman in the final, 6–2, 6–7(6–8), [12–10] to win the men's doubles tennis title at the 2022 Italian Open.[1] The pair saved a championship point en route to their tenth career title as a team.
The following are the seeded teams, based on ATP rankings as of 2 May 2022.