The 2021–22 season was the 129th season in the existence of Hertha BSC and the club's ninth consecutive season in the top flight of German football. In addition to the domestic league, Hertha BSC participated in this season's edition of the DFB-Pokal.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
As a result of their 16th-place finish in the regular season, the club qualified for the play-off match with the third-place team in the 2021–22 2. Bundesliga, Hamburger SV, to determine whether the club would remain in the 2022–23 Bundesliga.