The 2010 U.S. Open 9-ball Championship is the 35th annual men's U.S. Open 9-Ball Championships. The championship was held at Chesapeake Conference Center, Chesapeake, Virginia from October 17 to 23, 2010. Finland's Mika Immonen was the defending champion. Unlike most sports tournaments, women are allowed to enter the main draw. The event was won by Darren Appleton defeating Corey Deuel 15–13 in the final.
*Forfeit