The 2005 Kilkenny Senior Hurling Championship was the 111th staging of the Kilkenny Senior Hurling Championship since its establishment by the Kilkenny County Board.
James Stephens were the defending champions.[1]
On 2 October 2005, Glenmore were relegated after a 2–11 to 0–15 defeat by Fenians.
On 23 October 2005, James Stephens won the title after a 1–18 to 2–12 defeat of Ballyhale Shamrocks in the final at Nowlan Park.[2] It was their eighth championship title overall and their second title in succession.
Eoin Larkin from the James Stephens club was the championship's top scorer with 0-25.
Promoted from the Kilkenny Intermediate Hurling Championship
Relegated to the Kilkenny Intermediate Hurling Championship