2-phospho-L-lactate transferase

2-phospho-L-lactate transferase
Identifiers
EC no.	2.7.8.28
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

2-phospho-L-lactate transferase (EC 2.7.8.28, LPPG:Fo 2-phospho-L-lactate transferase, LPPG:7,8-didemethyl-8-hydroxy-5-deazariboflavin 2-phospho-L-lactate transferase, MJ1256, lactyl-2-diphospho-(5')guanosine:Fo 2-phospho-L-lactate transferase, CofD) is an enzyme with systematic name (2S)-lactyl-2-diphospho-5'-guanosine:7,8-didemethyl-8-hydroxy-5-deazariboflavin 2-phospho-L-lactate transferase.^[1][2] This enzyme catalyses the following chemical reaction

(2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin ${\displaystyle \rightleftharpoons }$ GMP + coenzyme F420-0

This enzyme is involved in the biosynthesis of coenzyme F420.

References

1. Graupner M, Xu H, White RH (March 2002). "Characterization of the 2-phospho-L-lactate transferase enzyme involved in coenzyme F(420) biosynthesis in Methanococcus jannaschii". Biochemistry. 41 (11): 3754–61. doi:10.1021/bi011937v. PMID 11888293.
2. Forouhar F, Abashidze M, Xu H, Grochowski LL, Seetharaman J, Hussain M, Kuzin A, Chen Y, Zhou W, Xiao R, Acton TB, Montelione GT, Galinier A, White RH, Tong L (April 2008). "Molecular insights into the biosynthesis of the F420 coenzyme". The Journal of Biological Chemistry. 283 (17): 11832–40. doi:10.1074/jbc.m710352200. PMC 2431047. PMID 18252724.

External links

• 2-phospho-L-lactate+transferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)