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1451 in various calendars
Gregorian calendar	1451; MCDLI
Ab urbe condita	2204
Armenian calendar	900; ԹՎ Ջ
Assyrian calendar	6201
Balinese saka calendar	1372–1373
Bengali calendar	858
Berber calendar	2401
English Regnal year	29 Hen. 6 – 30 Hen. 6
Buddhist calendar	1995
Burmese calendar	813
Byzantine calendar	6959–6960
Chinese calendar	庚午年 (Metal Horse); 4148 or 3941; — to —; 辛未年 (Metal Goat); 4149 or 3942
Coptic calendar	1167–1168
Discordian calendar	2617
Ethiopian calendar	1443–1444
Hebrew calendar	5211–5212
Hindu calendars
- Vikram Samvat	1507–1508
- Shaka Samvat	1372–1373
- Kali Yuga	4551–4552
Holocene calendar	11451
Igbo calendar	451–452
Iranian calendar	829–830
Islamic calendar	854–855
Japanese calendar	Hōtoku 3; (宝徳３年)
Javanese calendar	1366–1367
Julian calendar	1451; MCDLI
Korean calendar	3784
Minguo calendar	461 before ROC; 民前461年
Nanakshahi calendar	−17
Thai solar calendar	1993–1994
Tibetan calendar	阳金马年; (male Iron-Horse); 1577 or 1196 or 424; — to —; 阴金羊年; (female Iron-Goat); 1578 or 1197 or 425

Millennium:	2nd millennium
Centuries:	14th century; 15th century ; 16th century;
Decades:	1430s; 1440s; 1450s ; 1460s; 1470s;
Years:	1448; 1449; 1450; 1451 ; 1452; 1453; 1454;

Events

January 7 – Pope Nicholas V issues a Papal Bull^[1] to establish The University of Glasgow; classes are initially held in Glasgow Cathedral.
February 3 – Murad II, Sultan of the Ottoman Empire, dies and is succeeded (on February 18) by his son, Mehmed II.
February 14 – Louis XI of France marries Charlotte of Savoy.
April 11 – Celje acquires market town status and town rights, by orders from Count Frederic II of Celje.
April 19 – In the Delhi Sultanate, the Afghan Lodi Dynasty succeeds the Turkish Sayyid Dynasty.
June 30 – French troops under Jean de Dunois invade Guyenne, and capture Bordeaux.
August 20 – The French capture Bayonne, the last English stronghold in Guyenne.
October – After assassinating Bogdan II of Moldavia, Petru Aron takes up the throne.
October 28 – Revolt of Ghent: Ghent takes up arms against Philip the Good, Duke of Burgundy.

The Great Peacemaker along with Jigonhsasee and Hiawatha, found the Haudenosaunee, commonly called the Iroquois Confederacy

January 14 – Franchinus Gaffurius, Italian composer (d. 1522)
January 29 – John, Prince of Portugal, Prince of Portugal (d. 1451)
February 17 – Raffaello Maffei, Italian theologian (d. 1522)
March 5 – William Herbert, 2nd Earl of Pembroke, English earl (d. 1491)
March 9 – Amerigo Vespucci, Italian explorer (d. 1512)^[2]
April 22 – Queen Isabella I of Castile, Castillian queen regnant and first queen of a united Spain (by marriage to Ferdinand of Aragon) (d. 1504)^[3]
May 2 – René II, Duke of Lorraine (d. 1508)
May 17 – Engelbert II of Nassau, Count of Nassau-Vianden and Lord of Breda (1475–1504) (d. 1504)
June 1 – Giles Daubeney, 1st Baron Daubeney, English soldier, diplomat, courtier and politician (d. 1508)
July 10 – James III of Scotland (d. 1488)^[4]
September 5 – Isabel Neville, Duchess of Clarence, elder daughter of Richard Neville (d. 1476)^[5]
November 29 – Elisabeth of Brandenburg, Duchess of Württemberg (d. 1524)
date unknown
- Christopher Columbus, Italian-born explorer (d. 1506)^[6]
- Ignatius Noah of Lebanon, Syriac Orthodox patriarch of Antioch (d. 1509).^[7]
- Guru Jambheshwar, Rajasthani founder of the Bishnoi Panth (d. 1536)

January 7 – Antipope Felix V (b. 1383)
January 18 – Henry II, Count of Nassau-Siegen, Co-ruler of Nassau-Siegen (1442–1451) (b. 1414)^[8]
February 3 – Murad II, Ottoman Sultan (b. 1404)
June – ‘Abdullah, Timurid Empire ruler
July 11 – Barbara of Cilli, Holy Roman Empress, queen consort of Hungary and Bohemia (b. 1392)
October – Bogdan II of Moldavia, assassinated by Petru Aron
date unknown
- Stefan Lochner, German painter (b. 1400)
- John Lydgate, English monk and poet (b. 1370)
- al-Mustakfi II, Abbasid Caliph

^ "University of Glasgow :: Story :: The Papal Bull".
^ Chase's Editors; Contemporary Books (September 2002). Chase's Calendar of Events 2003. McGraw-Hill. p. 169. ISBN 978-0-07-139098-9.
^ Peggy K. Liss (2004). Isabel the Queen: Life and Times. University of Pennsylvania Press. p. 9. ISBN 978-0-8122-1897-8.
^ "King James III: Biography on Undiscovered Scotland". www.undiscoveredscotland.co.uk. Retrieved January 29, 2021.
^ Amy Licence (April 15, 2013). Anne Neville: Richard III's Tragic Queen. Amberley Publishing Limited. pp. 29–. ISBN 978-1-4456-1177-8.
^ "Christopher Columbus | Biography, Voyages, & Facts". Encyclopedia Britannica. Retrieved January 21, 2021.
^ Barsoum, Aphrem (2003). The Scattered Pearls: A History of Syriac Literature and Sciences. Translated by Matti Moosa (2nd ed.). Gorgias Press. pp. 508–509. Retrieved July 14, 2020.
^ Van den Berg, F.M. (1992). "Een Nassau's graf in Italië". In Van der Klooster, L.J.; Tiethoff-Spliethoff, M.E.; Tamse, C.A. & Elzenga, E. (eds.). Militaire entourage rondom Oranje en andere bijdragen over het Huis van Oranje. Oranje-Nassau Museum Jaarboek 1992 (in Dutch). Zutphen: Walburg Pers. p. 89. ISBN 90-6011-812-X.