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TMEM222
Identifikatori
Aliasi	TMEM222
Vanjski ID-jevi	MGI: 1098568 HomoloGene: 11999 GeneCards: TMEM222
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	27,336,400 bp
Lokacija gena (miš)
Hrom.	Hromosom 4 (miš)
Kraj	133,005,103 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ortolozi
	84065
	52174
	ENSG00000186501
	ENSMUSG00000028857
	Q9H0R3
	Q8BVA2
	NM_032125
	NM_025667
	NP_115501
	NP_079943
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Transmembranski protein 222 jest protein koji je kod ljudi kodiran genom TMEM222 sa hromosoma 1.^[5]^[6] Jedna od značajnih karakteristika proteina koji je kodiran ovim genom je prisustvo tri predviđena transmembranska domena.^[7] Predviđa se da se protein TMEM222 najvjerovatnije nalazi u sekretornim vezikulama.^[8]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 208 aminokiselina, a molekulska težina 23.230 Da.^[9]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAEAEGSSLL	LLPPPPPPPR	MAEVEAPTAA	ETDMKQYQGS	GGVAMDVERS
RFPYCVVWTP	IPVLTWFFPI	IGHMGICTST	GVIRDFAGPY	FVSEDNMAFG
KPAKYWKLDP	AQVYASGPNA	WDTAVHDASE	EYKHRMHNLC	CDNCHSHVAL
ALNLMRYNNS	TNWNMVTLCF	FCLLYGKYVS	VGAFVKTWLP	FILLLGIILT
VSLVFNLR

Genska svopjstva

TMEM222 ima domen nepoznate funkcije (DUF778).^[10] Aliases of this gene include DKFZP564D0478, RP11-4K3__A.4, C1orf160, and MGC111002.^[11] Pristupom NM_032125.2, vidi se da najduža kodirajuća sekvenca (1.629 bp), kodira protein od 208 aminokiselinskih ostataka (2.230 Da), koja se smatra konsenzusnom kodirajućom sekvencom (CCDS297.2).^[12] Slični su osim što drugom (Q9H0R3-2) nedostaje prvih 96 aminokiselinskih ostataka koji su prisutni u prvom (Q9H0R3-1).^[13]

Ekspresija gena

ACEVIEW je označio TMEM222 kao visoko eksprimiran sa 3,8 puta većom ekspresijom od prosječnog gena u bazi podataka.^[14] Postoje dokazi ekspresije iz 166 tkiva uključujući mozak, pluća, debelo crijevo, bubrege i placenta.^[14]

Homologija

Ortolozi i udaljeni homolozi ljudskog TMEM222 identificirani su širom eukariota, posebno kod biljaka i životinja.^[15] No paralogs of this gene have been found in the human genome.^[16]

Rod I vrsta	Uobičajeno ime	Pristupni broj	Dužina	Slčnost	Identitet sa ljudskim
Rattus norvegicus	Pacov	NP_001107252.1	208aa	99%	96%
Canis familiaris	Pas	XP_852505.1	208aa	98%	96%
Mus musculus	Miš	NP_079943.2	208aa	96%	95%
Sus scrofa	Svinja	XP_003127773.1	208aa	97%	94%
Equus caballus	Konj	XP_001917747.1	207aa	94%	93%
Gallus gallus	Kokoš	XP_417729.1	182aa	90%	85%
Danio rerio	Zebrica	NP_001013334.1	174aa	83%	71%
Anopheles gambiae	Komarac	XP_320483.3	197aa	66%	53%
Drosophila melanogaster	Fruit Fly	NP_723362.1	196aa	74%	61%
Caenorhabditis elegans	Nematoda	NP_494762.2	168aa	72%	55%
Phytophthora infestans	Kasna pjegavost (gljiva)	XP_002902629.1	186aa	59%	48%
Zea mays	Kukuruz	NP_001144071.1	233aa	61%	44%
Oryza sativa	Riža	NP_001051577.1	204aa	61%	43%
Arabidopsis thaliana	Thallova grbaštica	NP_190673.1	231aa	55%	36%
Homo sapiens	Čovjek	NP_115501.2	208	-	-

Udaljeni homolog

Daleki homolog TMEM222,^[15] RTH (RTE1-Homolog),^[17] je homolog RTE1 (reverzija percepcije etilena 1), za koji je poznato da izaziva konformacijske promjene u ETR1 (Etilenski receptor 1) koje rezultiraju negativnom regulacijom koja odgovara gubitku percepcije etilena.^[18]

Proteinske interakcije

Postoje dokazi iz kvaščevog dvohibridnog pregleda za dvije interakcije proteina sa ovim genom. Jedna je serinska proteaza (PRSS23)^[19] za koju je utvrđeno da sudjeluju u ovulacijama miša i izlučuju se u vanćelijski matriks.^[20] Drugi protein je ab-hidrolaza (HLA-B vezani transkript 5)^[21] koji je sastavni dio membrane, a njegov odgovarajući gen se nalazi u genomu u blizini faktora tumorske nekroze (TNF)-alfa i TNF-beta.^[22]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000186501 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028857 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
^ "Entrez Gene: C1orf160 chromosome 1 open reading frame 160".
^ TMHMM
^ k-NN
^ "UniProt, Q9H0R3" (jezik: eng.). Pristupljeno 3. 12. 2021.CS1 održavanje: nepoznati jezik (link)
^ NCBI (National Center for Biotechnology information)
^ Gene Cards
^ Uniprot
^ Uniprot
^ ^a ^b ACEVIEW
^ ^a ^b Homologene
^ BLAST
^ "RTH RTE1-homolog [Arabidopsis thaliana (thale cress)] - Gene - NCBI".
^ Resnick JS, Wen CK, Shockey JA, Chang C (maj 2006). "REVERSION-TO-ETHYLENE SENSITIVITY1, a conserved gene that regulates ethylene receptor function in Arabidopsis". Proc. Natl. Acad. Sci. U.S.A. 103 (20): 7917–22. doi:10.1073/pnas.0602239103. PMC 1458508. PMID 16682642.
^ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (septembar 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
^ Miyakoshi K, Murphy MJ, Yeoman RR, Mitra S, Dubay CJ, Hennebold JD (decembar 2006). "The identification of novel ovarian proteases through the use of genomic and bioinformatic methodologies". Biol. Reprod. 75 (6): 823–35. doi:10.1095/biolreprod.106.052290. PMID 16870946.
^ Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (januar 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
^ Spies T, Bresnahan M, Strominger JL (novembar 1989). "Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B". Proc. Natl. Acad. Sci. U.S.A. 86 (22): 8955–8. Bibcode:1989PNAS...86.8955S. doi:10.1073/pnas.86.22.8955. PMC 298409. PMID 2813433.

Dopunska literatura

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000186501 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028857 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11230166-5] Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.

[entrez-6] "Entrez Gene: C1orf160 chromosome 1 open reading frame 160".

[7] TMHMM

[8] -NN

[UniProt-9] "UniProt, Q9H0R3" (jezik: eng.). Pristupljeno 3. 12. 2021.CS1 održavanje: nepoznati jezik (link)

[10] NCBI (National Center for Biotechnology information)

[11] Gene Cards

[12] Uniprot

[13] Uniprot

[ACEVIEW_[https://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?db=human&term=TMEM222&submit=Go]-14] ACEVIEW

[Homologene_[https://www.ncbi.nlm.nih.gov/gene?Db=homologene&DbFrom=gene&Cmd=Link&LinkName=gene_homologene&LinkReadableName=HomoloGene&IdsFromResult=84065]-15] Homologene

[16] BLAST

[17] "RTH RTE1-homolog [Arabidopsis thaliana (thale cress)] - Gene - NCBI".

[pmid16682642-18] Resnick JS, Wen CK, Shockey JA, Chang C (maj 2006). "REVERSION-TO-ETHYLENE SENSITIVITY1, a conserved gene that regulates ethylene receptor function in Arabidopsis". Proc. Natl. Acad. Sci. U.S.A. 103 (20): 7917–22. doi:10.1073/pnas.0602239103. PMC 1458508. PMID 16682642.

[pmid16169070-19] Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (septembar 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.

[pmid16870946-20] Miyakoshi K, Murphy MJ, Yeoman RR, Mitra S, Dubay CJ, Hennebold JD (decembar 2006). "The identification of novel ovarian proteases through the use of genomic and bioinformatic methodologies". Biol. Reprod. 75 (6): 823–35. doi:10.1095/biolreprod.106.052290. PMID 16870946.

[pmid14667819-21] Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (januar 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.

[pmid2813433-22] Spies T, Bresnahan M, Strominger JL (novembar 1989). "Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B". Proc. Natl. Acad. Sci. U.S.A. 86 (22): 8955–8. Bibcode:1989PNAS...86.8955S. doi:10.1073/pnas.86.22.8955. PMC 298409. PMID 2813433.

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