SLC39A1

SLC39A1
Identifikatori
Aliasi	SLC39A1
Vanjski ID-jevi	OMIM: 604740 MGI: 1353474 HomoloGene: 40906 GeneCards: SLC39A1
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek)[1] Bend 1q21.3 Početak 153,959,099 bp[1] Kraj 153,968,184 bp[1]
Lokacija gena (miš) Hrom. Hromosom 3 (miš)[2] Bend 3|3 F1 Početak 90,155,479 bp[2] Kraj 90,160,919 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • metal ion transmembrane transporter activity • inorganic cation transmembrane transporter activity • zinc ion transmembrane transporter activity • signaling receptor binding Ćelijska komponenta • integral component of membrane • ćelijska membrana • endoplasmic reticulum membrane • membrana • Endoplazmatski retikulum Biološki proces • embryonic cranial skeleton morphogenesis • GO:0070839 metal ion transport • zinc ion transmembrane transport • cation transport • zinc ion transport • in utero embryonic development • ion transport • limb development • transmembrane transport Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	27173	30791
Ensembl	ENSG00000143570	ENSMUSG00000052310
UniProt	Q9NY26	Q9QZ03
RefSeq (mRNK)	NM_014437 NM_001271957 NM_001271958 NM_001271959 NM_001271960 NM_001271961	NM_013901
RefSeq (bjelančevina)	NP_001258886 NP_001258887 NP_001258888 NP_001258889 NP_001258890 NP_055252	NP_038929
Lokacija (UCSC)	Chr 1: 153.96 – 153.97 Mb	Chr 3: 90.16 – 90.16 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Cinkov transporter ZIP1 jest protein koji je kod ljudi kodiran genom SLC39A1 sa hromosoma 1.^[5][6][7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 324 aminokiseline, a molekulska težina 34.250 Da.^[8]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MGPWGEPELL		VWRPEAVASE		PPVPVGLEVK		LGALVLLLVL		TLLCSLVPIC
VLRRPGANHE		GSASRQKALS		LVSCFAGGVF		LATCLLDLLP		DYLAAIDEAL
AALHVTLQFP		LQEFILAMGF		FLVLVMEQIT		LAYKEQSGPS		PLEETRALLG
TVNGGPQHWH		DGPGVPQASG		APATPSALRA		CVLVFSLALH		SVFEGLAVGL
QRDRARAMEL		CLALLLHKGI		LAVSLSLRLL		QSHLRAQVVA		GCGILFSCMT
PLGIGLGAAL		AESAGPLHQL		AQSVLEGMAA		GTFLYITFLE		ILPQELASSE
QRILKVILLL		AGFALLTGLL		FIQI

Funkcija

Protein ZIP1 odgovoran je za aktivni transport cinka u ćelije prostate. U mnogim slučajevima karcinoma prostate, SLC39A1 je utišan zbog čega ćelije kanceri prostate imaju nizak sadržaj cinka.^[9]

Također pogledajte

• Rastvorni nosač

Reference

1. GRCh38: Ensembl release 89: ENSG00000143570 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000052310 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lioumi M, Ferguson CA, Sharpe PT, Freeman T, Marenholz I, Mischke D, Heizmann C, Ragoussis J (Feb 2000). "Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex". Genomics. 62 (2): 272–80. doi:10.1006/geno.1999.5993. PMID 10610721.
6. Gaither LA, Eide DJ (Mar 2000). "Functional expression of the human hZIP2 zinc transporter". J Biol Chem. 275 (8): 5560–4. doi:10.1074/jbc.275.8.5560. PMID 10681536.
7. "Entrez Gene: SLC39A1 solute carrier family 39 (zinc transporter), member 1".
8. "UniProt, Q9NY26" (jezik: engleski). Pristupljeno 18. 12. 2021.
9. Costello LC, Franklin RB (2006). "The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots". Mol. Cancer. 5: 17. doi:10.1186/1476-4598-5-17. PMC 1481516. PMID 16700911.

Dopunska literatura

• Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
• Gaither LA, Eide DJ (2001). "The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells". J. Biol. Chem. 276 (25): 22258–64. doi:10.1074/jbc.M101772200. PMID 11301334.
• Milon B, Dhermy D, Pountney D, et al. (2001). "Differential subcellular localization of hZip1 in adherent and non-adherent cells". FEBS Lett. 507 (3): 241–6. doi:10.1016/S0014-5793(01)02950-7. PMID 11696349.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Franklin RB, Ma J, Zou J, et al. (2003). "Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells". J. Inorg. Biochem. 96 (2–3): 435–42. doi:10.1016/S0162-0134(03)00249-6. PMC 4465841. PMID 12888280.
• Dufner-Beattie J, Langmade SJ, Wang F, et al. (2004). "Structure, function, and regulation of a subfamily of mouse zinc transporter genes". J. Biol. Chem. 278 (50): 50142–50. doi:10.1074/jbc.M304163200. PMID 14525987.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Franklin RB, Feng P, Milon B, et al. (2006). "hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer". Mol. Cancer. 4: 32. doi:10.1186/1476-4598-4-32. PMC 1243239. PMID 16153295.
• Tang Z, Sahu SN, Khadeer MA, et al. (2006). "Overexpression of the ZIP1 zinc transporter induces an osteogenic phenotype in mesenchymal stem cells". Bone. 38 (2): 181–98. doi:10.1016/j.bone.2005.08.010. PMID 16203195.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Huang L, Kirschke CP (2007). "A di-leucine sorting signal in ZIP1 (SLC39A1) mediates endocytosis of the protein". FEBS J. 274 (15): 3986–97. doi:10.1111/j.1742-4658.2007.05933.x. PMID 17635580. S2CID 21792127.

Vanjski linkovi