Meta-Tiramin

meta-Tiramin

Općenito
Hemijski spojmeta-Tiramin
Druga imenam-Tiramin; 3-Tiramin;
3-Hidroksifeniletilamin
IUPAC ime:3-(2-Aminoetil)fenol
Molekularna formulaC8H11NO
CAS registarski broj588-05-6
Osobine1
1 Gdje god je moguće korištene su SI jedinice. Ako nije drugačije naznačeno, dati podaci vrijede pri standardnim uslovima.

meta-Tiramin, poznat i kao m-tiramin i 3-tiramin, je endogeni amin u tragovima neuromodulator i strukturni analog fenetilamina.[1][2][3] To pozicijski izomer para -tiramina i, slično njemu, ima učinke na adrenergične i dopaminergične sisteme.[4][5]

Kod ljudi, meta-tiramin se proizvodi posredstvom metabolizma meta-tirozina uz katalizu enzimom dekarboksilaza aromatskih aminokiselina.[6] Također kod ljudi, ovaj spoj može se metabolizirati i u dopamin, preko perifernog ili moždanog CYP2D6 enzima.[7]

Također pogledajte

Reference

  1. ^ Boulton AA, Huebert ND (novembar 1981). "Biosynthesis of some urinary trace amines in the rat and the human". Research Communications in Chemical Pathology and Pharmacology. 34 (2): 295–310. PMID 7335956.
  2. ^ Dyck LE, Juorio AV, Boulton AA (juni 1982). "The in vitro release of endogenous m-tyramine, p-tyramine and dopamine from rat striatum". Neurochemical Research. 7 (6): 705–16. doi:10.1007/bf00965523. PMID 7121718.
  3. ^ Sardar A, Juorio AV, Boulton AA (juni 1987). "The concentration of p- and m-tyramine in the rat mesolimbic system: its regional distribution and effect of monoamine oxidase inhibition". Brain Research. 412 (2): 370–4. doi:10.1016/0006-8993(87)91145-0. PMID 3607473.
  4. ^ Dyck LE, Kazakoff CW, Dourish CT (oktobar 1982). "The role of catecholamines, 5-hydroxytryptamine and m-tyramine in the behavioural effects of m-tyrosine in the rat". European Journal of Pharmacology. 84 (3–4): 139–49. doi:10.1016/0014-2999(82)90196-0. PMID 7173317.
  5. ^ McQuade PS, Wood PL (1984). "The effects of administration of meta-tyramine and para-tyramine on dopamine and its metabolites in the rat striatum". Progress in Neuro-psychopharmacology & Biological Psychiatry. 8 (4–6): 705–9. doi:10.1016/0278-5846(84)90042-3. PMID 6531442.
  6. ^ "EC 4.1.1.28 – Aromatic-L-amino-acid decarboxylase (Homo sapiens)". BRENDA. Technische Universität Braunschweig. juli 2016. Pristupljeno 7. 10. 2016. Substrate: m-tyrosine

    Product: m-tyramine + CO2

    Organism: Homo sapiens
    Reaction diagram
  7. ^ Wang X, Li J, Dong G, Yue J (februar 2014). "The endogenous substrates of brain CYP2D". Eur. J. Pharmacol. 724: 211–218. doi:10.1016/j.ejphar.2013.12.025. PMID 24374199.

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