XCL2

XCL2
Identifiers
Aliases	XCL2, SCM-1b, SCM1B, SCYC2, chemokine (C motif) ligand 2, X-C motif chemokine ligand 2
External IDs	OMIM: 604828; MGI: 104593; HomoloGene: 130513; GeneCards: XCL2; OMA:XCL2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q24.2 Start 168,540,768 bp[1] End 168,543,997 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H2.2|1 72.26 cM Start 164,759,213 bp[2] End 164,763,096 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte spleen blood lymph node bone marrow duodenum appendix epithelium of colon placenta right lobe of liver Top expressed in thymus granulocyte mesenteric lymph nodes spleen blood choroid plexus of fourth ventricle right kidney secondary oocyte jejunum uterus More reference expression data BioGPS n/a
Gene ontology Molecular function cytokine activity protein binding CCR chemokine receptor binding chemokine activity Cellular component extracellular region extracellular space Biological process monocyte chemotaxis chemokine-mediated signaling pathway cellular response to tumor necrosis factor blood circulation neutrophil chemotaxis chemotaxis positive regulation of GTPase activity cellular response to interleukin-1 immune response positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma lymphocyte chemotaxis inflammatory response signal transduction regulation of signaling receptor activity G protein-coupled receptor signaling pathway positive regulation of T cell chemotaxis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6846 16963 Ensembl ENSG00000143185 ENSMUSG00000026573 UniProt Q9UBD3 P47993 RefSeq (mRNA) NM_003175 NM_008510 RefSeq (protein) NP_003166 NP_032536 Location (UCSC) Chr 1: 168.54 – 168.54 Mb Chr 1: 164.76 – 164.76 Mb PubMed search [3] [4]
Wikidata
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Chemokine (C motif) ligand 2 (XCL2) is a small cytokine belonging to the XC chemokine family that is highly related to another chemokine called XCL1.^[5] It is predominantly expressed in activated T cells, but can also be found at low levels in unstimulated cells. XCL2 induces chemotaxis of cells expressing the chemokine receptor XCR1.^[6] Its gene is located on chromosome 1 in humans.^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000143185 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026573 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kennedy J, Kelner G, Kleyensteuber S, Schall T, Weiss M, Yssel H, Schneider P, Cocks B, Bacon K, Zlotnik A (1995). "Molecular cloning and functional characterization of human lymphotactin". J Immunol. 155 (1): 203–9. doi:10.4049/jimmunol.155.1.203. PMID 7602097.
6. Yoshida T, Imai T, Kakizaki M, Nishimura M, Takagi S, Yoshie O (1998). "Identification of single C motif-1/lymphotactin receptor XCR1". J Biol Chem. 273 (26): 16551–4. doi:10.1074/jbc.273.26.16551. PMID 9632725.
7. Yoshida T, Imai T, Takagi S, Nishimura M, Ishikawa I, Yaoi T, Yoshie O (1996). "Structure and expression of two highly related genes encoding SCM-1/human lymphotactin". FEBS Lett. 395 (1): 82–8. Bibcode:1996FEBSL.395...82Y. doi:10.1016/0014-5793(96)01004-6. PMID 8849694.