CXCL15

Cxcl15
Identifiers
Aliases	chemokine (C-X-C motif) ligand 15Il8Scyb15lungkineweche
External IDs	GeneCards: [1]; OMA:- orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5 E1|5 44.78 cM Start 90,942,393 bp End 90,950,926 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left lung lobe right lung lobe trachea cervix sexually immature organism mammary gland external carotid artery lobe of prostate genital tubercle nucleus accumbens n/a More reference expression data BioGPS n/a
Gene ontology Molecular function chemokine activity cytokine activity CXCR3 chemokine receptor binding Cellular component extracellular region extracellular space Biological process chemotaxis chemokine-mediated signaling pathway G protein-coupled receptor signaling pathway response to lipopolysaccharide inflammatory response regulation of cell population proliferation immune response neutrophil chemotaxis positive regulation of leukocyte chemotaxis defense response T cell chemotaxis regulation of signaling receptor activity hemopoiesis leukocyte chemotaxis antimicrobial humoral immune response mediated by antimicrobial peptide cellular response to lipopolysaccharide Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 20309 n/a Ensembl ENSMUSG00000029375 n/a UniProt Q9WVL7 n/a RefSeq (mRNA) NM_011339 n/a RefSeq (protein) NP_035469 n/a Location (UCSC) Chr 5: 90.94 – 90.95 Mb n/a PubMed search [1] n/a
Wikidata
View/Edit Human

Chemokine (C-X-C motif) ligand 15 (CXCL15) is a small cytokine belonging to the CXC chemokine family that has been described in the mouse. This chemokine is also known under the name lungkine. CXCL15 is an ELR+ CXC chemokine (it contains the amino acid sequence E-L-R immediately before its CXC motif) that recruits neutrophils during inflammation of the lungs. It is highly abundant in epithelial cells of the lung,^[2] and can also be found in other mucosal organs such as the urogenital and gastrointestinal tracts, and in endocrine organs like the adrenal gland.^[3] The gene for CXCL15 is found on mouse chromosome 5.

References

1. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
2. Rossi D, Hurst S, Xu Y, Wang W, Menon S, Coffman R, Zlotnik A (1999). "Lungkine, a novel CXC chemokine, specifically expressed by lung bronchoepithelial cells". J Immunol. 162 (9): 5490–7. doi:10.4049/jimmunol.162.9.5490. PMID 10228029.
3. Schmitz J, McCracken V, Dimmitt R, Lorenz R (2007). "Expression of CXCL15 (Lungkine) in Murine Gastrointestinal, Urogenital, and Endocrine Organs". J Histochem Cytochem. 55 (5): 515–24. doi:10.1369/jhc.6A7121.2007. PMID 17242461.