PSB-SB-487

PSB-SB-487
Identifiers
  • 7-(1,1-Dimethyloctyl)-5-hydroxy-3-(2-hydroxybenzyl)-2H-chromen-2-one
CAS Number
PubChem CID
ChemSpider
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC26H32O4
Molar mass408.538 g·mol−1
3D model (JSmol)
  • OC1=C(CC2=CC3=C(C=C(C(C)(C)CCCCCCC)C=C3O)OC2=O)C=CC=C1
  • InChI=1S/C26H32O4/c1-4-5-6-7-10-13-26(2,3)20-16-23(28)21-15-19(25(29)30-24(21)17-20)14-18-11-8-9-12-22(18)27/h8-9,11-12,15-17,27-28H,4-7,10,13-14H2,1-3H3
  • Key:YNWOMOUVWNKICO-UHFFFAOYSA-N

PSB-SB-487 is an experimental drug which is used as a pharmacological research tool. It is a coumarin derivative which is an antagonist at the former orphan receptor GPR55. Unlike older GPR55 antagonists such as O-1918, PSB-SB-487 has good selectivity over the related receptor GPR18, with an IC50 of 113nM at GPR55 vs 12500nM at GPR18.[1] However it has poorer selectivity over other related receptors, acting as a weak antagonist at CB1 with a Ki of 1170nM, and a partial agonist at CB2 with a Ki of 292nM.[2]

See also

References

  1. ^ Rempel V, Volz N, Gläser F, Nieger M, Bräse S, Müller CE (June 2013). "Antagonists for the orphan G-protein-coupled receptor GPR55 based on a coumarin scaffold". Journal of Medicinal Chemistry. 56 (11): 4798–810. doi:10.1021/jm4005175. PMID 23679955.
  2. ^ Rempel V, Volz N, Hinz S, Karcz T, Meliciani I, Nieger M, et al. (September 2012). "7-Alkyl-3-benzylcoumarins: a versatile scaffold for the development of potent and selective cannabinoid receptor agonists and antagonists". Journal of Medicinal Chemistry. 55 (18): 7967–77. doi:10.1021/jm3008213. PMID 22916707.


Read other articles:

Sporting event delegationIndia at the1964 Summer OlympicsIOC codeINDNOCIndian Olympic AssociationWebsiteolympic.ind.inin TokyoCompetitors53 (52 men, 1 woman) in 8 sportsFlag bearer Gurbachan Singh RandhawaMedalsRanked 24th Gold 1 Silver 0 Bronze 0 Total 1 Summer Olympics appearances (overview)19001904–19121920192419281932193619481952195619601964196819721976198019841988199219962000200420082012201620202024 India competed at the 1964 Summer Olympics in Tokyo, Japan. 53 competitors, 52 men...

 

هذه المقالة يتيمة إذ تصل إليها مقالات أخرى قليلة جدًا. فضلًا، ساعد بإضافة وصلة إليها في مقالات متعلقة بها. (نوفمبر 2019) هاوبتفيلدڤيبل تعديل مصدري - تعديل   هاوبتفيلدڤيبل ( HptFw أو HF ) هي ثالث أعلى رتبة من رتب ضباط الصف في الجيش الألماني والقوات الجوية الألمانية.[1] التاريخ ...

 

Pour les articles homonymes, voir Bataille de Kosovo. Bataille de Kosovo Bataille de Kosovo (Chronique illustrée d'Ivan le Terrible - XVIe siècle) Informations générales Date 15 juin 1389 Lieu Proximité d'Obilic (actuel Kosovo) Issue Victoire stratégique des Ottomans Belligérants Empire ottoman Royaume de Serbie de Lazar Hrebeljanović duché de Bosnie de Tvrtko Ier Commandants Mourad Ier (†)Bayezid IerYakub (†) Lazar Hrebeljanović (†)Vlatko Vuković (en)Vuk Branković...

Dan Burn Informasi pribadiNama lengkap Daniel Johnson Burn[1]Tanggal lahir 9 Mei 1992 (umur 31)Tempat lahir Blyth, InggrisTinggi 6 ft 7 in (2,01 m)Posisi bermain BekInformasi klubKlub saat ini Brighton & Hove AlbionNomor 33Karier junior Newcastle United New Hartley Blyth Town Blyth Spartans2009 DarlingtonKarier senior*Tahun Tim Tampil (Gol)2009–2011 Darlington 14 (0)2011–2016 Fulham 61 (1)2012–2013 → Yeovil Town (pinjaman) 34 (2)2013–2014 → Birmingh...

 

Bagian dari seriIslam Rukun Iman Keesaan Allah Nabi dan Rasul Allah Kitab-kitab Allah Malaikat Hari Kiamat Qada dan Qadar Rukun Islam Syahadat Salat Zakat Puasa Haji Sumber hukum Islam al-Qur'an Sunnah (Hadis, Sirah) Tafsir Akidah Fikih Syariat Sejarah Garis waktu Muhammad Ahlulbait Sahabat Nabi Khulafaur Rasyidin Khalifah Imamah Ilmu pengetahuan Islam abad pertengahan Penyebaran Islam Penerus Muhammad Budaya dan masyarakat Akademik Akhlak Anak-anak Dakwah Demografi Ekonomi Feminisme Filsafat...

 

Banco Central de la Gambia Sede del banco central de GambiaBanco central de GambiaSede BanjulFundación 1971Gobernador Bakary Jammeh(2017)Divisa DalasiGMD (ISO 4217)Sitio web www.cbg.gm[editar datos en Wikidata] El Banco Central de la Gambia (en inglés: Central Bank of The Gambia) es el banco central de la Gambia.[1]​ Operaciones Como banco central, es responsable de proporcionar servicios bancarios al gobierno de Gambia, administrar tasas de inter

Pinus mugo; Zweig mit getrennten Blüten beiderlei Geschlechts Männliche (oben) und weibliche Blüte der Wassermelone (Citrullus lanatus). Monözie (altgriechisch μόνος mónos „allein“, „einzig“ und οἰκία oikia „Haus“) oder Einhäusigkeit beschreibt Samenpflanzen, die zugleich weibliche (karpel-, pistillate) und männliche (staminate) Blüten auf einem Pflanzenexemplar (Sporophyt) tragen. Die Blüten selber sind eingeschlechtig, haben also entweder nur (männliche) Sta...

 

Antibakteri adalah zat yang dapat mengganggu pertumbuhan atau bahkan mematikan bakteri dengan cara mengganggu metabolisme mikrob yang merugikan.[1] Mikroorganisme dapat menyebabkan bahaya karena kemampuan menginfeksi dan menimbulkan penyakit serta merusak bahan pangan. Antibakteri termasuk kedalam antimikroba yang digunakan untuk menghambat pertumbuhan bakteri.[2] Kriteria Antibakteri hanya dapat digunakan jika mempunyai sifat tosik selektif, artinya dapat membunuh bakteri yan...

 

1942 film BasantTheatrical release posterDirected byAmiya ChakrabartyScreenplay byAmiya ChakrabartyStory byAmiya ChakrabartyProduced byBombay TalkiesStarringMumtaz Shanti MadhubalaUlhasKanu RoyCinematographyR.D. MathurEdited byR.G. GopeMusic byPannalal GhoshRelease date 29 July 1942 (1942-07-29) [1]Running time146 minutesCountryIndiaLanguageHindustaniBox officeest. ₹0.8 crore (est. ₹235 crore as of 2016) Basant (transl. Spring) is a 1942 pre-partition Indian r...

Wat Ratchaburana: Grundriss und rekonstruierte Ansicht Blick vom Wat Phra Mahathat auf den Prang des Wat Ratchaburana Der Wat Ratchaburana (auch Wat Ratburana, Thai วัดราชบุรณะ พระนครศรีอยุธยา, sprich: [wát râːt buː-rá-ná prá-ná-kon sĭ à-yú-tá-yaː]) ist eine buddhistische Tempelanlage (Wat) im Geschichtspark Ayutthaya, Zentralthailand. Inhaltsverzeichnis 1 Lage 2 Baugeschichte 3 Sehenswürdigkeiten 4 Denkmalpflege 5 Trivia 6 Ein...

 

For other places with the same name, see Kajetanów. Village in Łódź Voivodeship, PolandKajetanówVillageKajetanówCoordinates: 51°0′40″N 20°0′20″E / 51.01111°N 20.00556°E / 51.01111; 20.00556Country PolandVoivodeshipŁódźCountyRadomskoGminaPrzedbórz Kajetanów [kajɛˈtanuf] is a village in the administrative district of Gmina Przedbórz, within Radomsko County, Łódź Voivodeship, in central Poland.[1] It lies approximately 12 kilometr...

 

Balsha IslandLocation of Varna Peninsula on Livingston Island in the South Shetland IslandsBalsha IslandLocation of Balsha IslandShow map of Antarctic PeninsulaBalsha IslandBalsha Island (Antarctica)Show map of AntarcticaGeographyLocationAntarcticaCoordinates62°28′24″S 60°11′35″W / 62.47333°S 60.19306°W / -62.47333; -60.19306ArchipelagoDunbar IslandsSouth Shetland IslandsArea0.17 km2 (0.066 sq mi)[1]Length0.6 km (0.37 mi)Wid...

2012 studio album by Max RichterRecomposed by Max Richter: Vivaldi – The Four SeasonsStudio album by Max RichterReleasedAugust 31, 2012RecordedMarch 12–13, 2012StudioB-Sharp, Berlin, GermanyGenre Contemporary classical post-minimalist baroque Length43:58LabelUniversalDeutsche GrammophonProducerMax RichterMax Richter chronology Infra(2010) Recomposed by Max Richter: Vivaldi – The Four Seasons(2012) Sleep(2015) Alternative cover2014 Deutsche Grammophon cover Alternative cover2014 ...

 

«Кизилжар» Повна назва Футбольний клубКизилжар СК Засновано 1968 Населений пункт Петропавловськ,  Казахстан Стадіон «Карасай» Вміщує 12 000 Президент Григорій Лорія Головний тренер Володимир Фомичов Ліга Прем'єр-ліга Казахстану 2023 -те Прем'єр-ліга Казахстану Домашня Виї...

 

此條目需要編修,以確保文法、用詞、语气、格式、標點等使用恰当。 (2023年1月12日)請按照校對指引,幫助编辑這個條目。(幫助、討論) 系列条目量子力学 i ℏ ∂ ∂ t | ψ ( t ) ⟩ = H ^ | ψ ( t ) ⟩ {\displaystyle i\hbar {\frac {\partial }{\partial t}}|\psi (t)\rangle ={\hat {H}}|\psi (t)\rangle } 薛定谔方程 入门 术语(英语:Glossary of elementary quantum mechanics) 历史...

Hohe MarterNuremberg U-Bahn stationGeneral informationLocationSchweinauer Hauptstraße 90441 Nürnberg, GermanyCoordinates49°25′43″N 11°02′38″E / 49.4287483°N 11.0437671°E / 49.4287483; 11.0437671Operated byVerkehrs-Aktiengesellschaft NürnbergLine(s)Connections Bus 35 Röthenbach - Thon65 Röthenbach - Röthenbach ConstructionStructure typeUndergroundOther informationFare zoneVGN: 100 and 200[1]HistoryOpened27 September 1986Services Preceding stati...

 

Subspecies of snake Eastern milk snake Adult eastern milk snake in Tennessee Scientific classification Domain: Eukaryota Kingdom: Animalia Phylum: Chordata Class: Reptilia Order: Squamata Suborder: Serpentes Family: Colubridae Genus: Lampropeltis Species: L. triangulum Subspecies: L. t. triangulum Trinomial name Lampropeltis triangulum triangulum(Lacépède, 1789) Synonyms[1][2] Coluber triangulum Lacépède, 1789 Lampropeltis triangula — Cope, 1860 Ophibolus trian...

 

Building in Georgia, United States This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: 1100 Peachtree – news · newspapers · books · scholar · JSTOR (May 2014) (Learn how and when to remove this template message) 1100 Peachtree1100 PeachtreeGeneral informationLocation1100 Peachtree St NEAtlanta, Georgia, United S...

Conseil de sécuritédes Nations uniesRésolution 333 Caractéristiques Date 22 mai 1973 Séance no  1716 Code S/RES/333 (Document) Vote Pour : 12Abs. : 3Contre : 0 Sujet Rhodésie du Sud Résultat Adoptée Membres permanents Conseil de sécurité 1973 Chine États-Unis France Royaume-Uni URSS Membres non permanents Australie Autriche Guinée Indonésie Inde Kenya Panama Pérou Soudan Yougoslavie Résolution no 332 Résolution no 334modifier La résolution 3...

 

Boutique Hotel in Fort Canning Downtown Core, SingaporeHotel Fort CanningLocation within SingaporeFormer namesAdministration Building of the British Far East Command Headquarters Singapore Command and Staff College Fort Canning Country ClubGeneral informationStatusCompletedTypeBoutique HotelArchitectural styleLow-riseLocation11 Canning Walk, Fort Canning Downtown Core, SingaporeCoordinates1°17′45″N 103°50′36″E / 1.2959°N 103.8433°E / 1.2959; 103.8433Complet...

 

Strategi Solo vs Squad di Free Fire: Cara Menang Mudah!