JWH-150

JWH-150

Legal status
Legal status	CA: Schedule II UK: Class B
Identifiers
IUPAC name (1-butyl-5-phenylpyrrol-3-yl)-naphthalen-1-ylmethanone
CAS Number	914458-18-7^Y
PubChem CID	44418303
ChemSpider	23277877^Y
CompTox Dashboard (EPA)	DTXSID701337047
Chemical and physical data
Formula	C25H23NO
Molar mass	353.465 g·mol^−1
3D model (JSmol)	Interactive image
SMILES CCCCN1C=C(C=C1C2=CC=CC=C2)C(=O)C3=CC=CC4=CC=CC=C43
InChI InChI=1S/C25H23NO/c1-2-3-16-26-18-21(17-24(26)20-11-5-4-6-12-20)25(27)23-15-9-13-19-10-7-8-14-22(19)23/h4-15,17-18H,2-3,16H2,1H3  ^Y Key:PTIAQHRJOQEMCO-UHFFFAOYSA-N ^Y

JWH-150 ((1-butyl-5-phenylpyrrol-3-yl)-naphthalen-1-ylmethanone) is a synthetic cannabinoid from the naphthoylpyrrole family which acts as an agonist of the CB₁ (K_i = 60 ± 1nM) and CB₂ (K_i = 15 ± 2nM) receptors, with a moderate four-fold selectivity for the CB₂ receptor. JWH-150 was first synthesized in 2006 by John W. Huffman and colleagues to examine the nature of ligand binding to the CB₁ receptor.^[1]

Legality

In the United States JWH-150 is not federally scheduled, although some states have passed legislation banning the sale, possession, and manufacture of JWH-150.^[2][3][4][5]

In Canada, JWH-150 and other naphthoylpyrrole-based cannabinoids are Schedule II controlled substances under the Controlled Drugs and Substances Act.^{[citation needed]}

In the United Kingdom, JWH-150 and other naphthoylpyrrole-based cannabinoids are considered Class B drugs under the Misuse of Drugs Act 1971.^{[citation needed]}

See also

• List of JWH cannabinoids
• Synthetic cannabinoid

References

1. Huffman JW, Padgett LW, Isherwood ML, Wiley JL, Martin BR (October 2006). "1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors". Bioorganic & Medicinal Chemistry Letters. 16 (20): 5432–5. doi:10.1016/j.bmcl.2006.07.051. PMID 16889960.
2. 21 U.S.C. § 812: Schedules of controlled substances
3. "The 2020 Florida Statutes". www.leg.state.fl.us. Retrieved 20 August 2021.
4. "Arizona Revised Statutes Title 13. Criminal Code § 13-3401". www.azleg.gov. Retrieved 20 August 2021.
5. "California Code, Health and Safety Code - HSC § 11357.5". Findlaw.