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JWH-251
Names
	Preferred IUPAC name 2-(2-Methylphenyl)-1-(1-pentyl-1H-indol-3-yl)ethan-1-one
Identifiers
CAS Number	864445-39-6 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL364820 ;
ChemSpider	9791472 ;
PubChem CID	11616723;
UNII	55H9NDH32M ;
CompTox Dashboard (EPA)	DTXSID80235555 ;
	InChI InChI=1S/C22H25NO/c1-3-4-9-14-23-16-20(19-12-7-8-13-21(19)23)22(24)15-18-11-6-5-10-17(18)2/h5-8,10-13,16H,3-4,9,14-15H2,1-2H3 Key: YBIPNGRKUAVSBG-UHFFFAOYSA-N ;
	SMILES O=C(c2c1ccccc1n(c2)CCCCC)Cc3ccccc3C;
Properties
Chemical formula	C22H25NO
Molar mass	319.448 g·mol−1
Pharmacology
Legal status	BR: Class F2 (Prohibited psychotropics); DE: Anlage II; US: Schedule I;
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

JWH-251 (1-pentyl-3-(2-methylphenylacetyl)indole) is a synthetic cannabinoid from the phenylacetylindole family, which acts as a cannabinoid agonist with about five times selectivity for CB₁ with a K_i of 29 nM and 146 nM at CB₂. Similar to the related 2'-methoxy compound JWH-250, the 2'-chloro compound JWH-203, and the 2'-bromo compound JWH-249, JWH-251 has a phenyl acetyl group in place of the naphthoyl ring used in most aminoalkylindole cannabinoid compounds.^[3]^[4]

In the United States, all CB₁ receptor agonists of the 3-phenylacetylindole class such as JWH-251 are Schedule I Controlled Substances.^[5]

References

^ "Stoffe gem. Anlagen zum BtMG". Retrieved 2024-11-23.
^ Anvisa (2023-07-24). "RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-07-25). Archived from the original on 2023-08-27. Retrieved 2023-08-27.
^ Huffman JW, Szklennik PV, Almond A, Bushell K, Selley DE, He H, et al. (September 2005). "1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles". Bioorganic & Medicinal Chemistry Letters. 15 (18): 4110–3. doi:10.1016/j.bmcl.2005.06.008. PMID 16005223.
^ Manera C, Tuccinardi T, Martinelli A (April 2008). "Indoles and related compounds as cannabinoid ligands". Mini Reviews in Medicinal Chemistry. 8 (4): 370–87. doi:10.2174/138955708783955935. PMID 18473928.
^ 21 U.S.C. § 812: Schedules of controlled substances