IL1RL2

IL1RL2
Identifiers
Aliases	IL1RL2, IL-1Rrp2, IL-36R, IL1R-rp2, IL1RRP2, interleukin 1 receptor like 2
External IDs	OMIM: 604512; MGI: 1913107; HomoloGene: 2860; GeneCards: IL1RL2; OMA:IL1RL2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q12.1 Start 102,187,006 bp[1] End 102,240,002 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 B Start 40,363,770 bp[2] End 40,406,722 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle skin of abdomen skin of leg right lobe of thyroid gland right lobe of liver cartilage tissue left lobe of thyroid gland right uterine tube minor salivary glands mucosa of transverse colon Top expressed in lip conjunctival fornix gastrula skin of external ear skin of back seminal vesicula esophagus epidermis hair follicle lacrimal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function interleukin-1, type I, activating receptor activity interleukin-1 receptor activity Cellular component integral component of membrane integral component of plasma membrane membrane plasma membrane Biological process positive regulation of T cell differentiation immune system process interleukin-1-mediated signaling pathway cellular defense response innate immune response inflammatory response signal transduction regulation of inflammatory response positive regulation of interleukin-6 production cytokine-mediated signaling pathway cellular response to cytokine stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8808 107527 Ensembl ENSG00000115598 ENSMUSG00000070942 UniProt Q9HB29 Q9ERS7 RefSeq (mRNA) NM_003854 NM_001351446 NM_001351447 NM_001351448 NM_001351449 NM_001351450 NM_133193 NM_001356478 RefSeq (protein) NP_003845 NP_001338375 NP_001338376 NP_001338377 NP_001338378 NP_001338379 NP_573456 NP_001343407 Location (UCSC) Chr 2: 102.19 – 102.24 Mb Chr 1: 40.36 – 40.41 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interleukin-1 receptor-like 2 is a protein that in humans is encoded by the IL1RL2 gene.^[5][6][7][8]

The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000115598 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000070942 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lovenberg TW, Crowe PD, Liu C, Chalmers DT, Liu XJ, Liaw C, Clevenger W, Oltersdorf T, De Souza EB, Maki RA (Dec 1996). "Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2)". J Neuroimmunol. 70 (2): 113–22. doi:10.1016/S0165-5728(96)00047-1. PMID 8898719. S2CID 53171191.
6. Dale M, Nicklin MJ (Jun 1999). "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q". Genomics. 57 (1): 177–9. doi:10.1006/geno.1999.5767. PMID 10191101.
7. Debets R, Timans JC, Homey B, Zurawski S, Sana TR, Lo S, Wagner J, Edwards G, Clifford T, Menon S, Bazan JF, Kastelein RA (Jul 2001). "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2". Journal of Immunology. 167 (3): 1440–6. doi:10.4049/jimmunol.167.3.1440. PMID 11466363.
8. "Entrez Gene: IL1RL2 interleukin 1 receptor-like 2".

Further reading

• McMahan CJ, Slack JL, Mosley B, et al. (1991). "A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types". EMBO J. 10 (10): 2821–32. doi:10.1002/j.1460-2075.1991.tb07831.x. PMC 452992. PMID 1833184.
• Colotta F, Re F, Muzio M, et al. (1993). "Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4". Science. 261 (5120): 472–5. Bibcode:1993Sci...261..472C. doi:10.1126/science.8332913. PMID 8332913.
• Torigoe K, Ushio S, Okura T, et al. (1997). "Purification and characterization of the human interleukin-18 receptor". J. Biol. Chem. 272 (41): 25737–42. doi:10.1074/jbc.272.41.25737. PMID 9325300.
• Born TL, Smith DE, Garka KE, et al. (2000). "Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling". J. Biol. Chem. 275 (39): 29946–54. doi:10.1074/jbc.M004077200. PMID 10882729.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ozkara C, Uzan M, Tanriverdi T, et al. (2006). "Lack of association between IL-1beta/alpha gene polymorphisms and temporal lobe epilepsy with hippocampal sclerosis". Seizure: The Journal of the British Epilepsy Association. 15 (5): 288–91. doi:10.1016/j.seizure.2006.02.016. PMID 16546408.