Carboxybiotin decarboxylase

Carboxybiotin decarboxylase
Identifiers
EC no.	7.2.4.1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Carboxybiotin decarboxylase (EC 7.2.4.1, MadB, carboxybiotin protein decarboxylase) is an enzyme with systematic name carboxybiotinyl-(protein) carboxy-lyase.^[1][2] This enzyme catalyses the following chemical reaction

a carboxybiotinyl-[protein] + n Na⁺_in + H⁺_out ${\displaystyle \rightleftharpoons }$ CO₂ + a biotinyl-[protein] + n Na⁺_out (n = 1--2)

This enzyme is an integral membrane protein MadB from the anaerobic bacterium Malonomonas rubra.

Nomenclature

This enzyme was previously classified as EC 4.3.99.2.

References

1. Berg M, Hilbi H, Dimroth P (April 1997). "Sequence of a gene cluster from Malonomonas rubra encoding components of the malonate decarboxylase Na+ pump and evidence for their function". European Journal of Biochemistry. 245 (1): 103–15. doi:10.1111/j.1432-1033.1997.00103.x. PMID 9128730.
2. Dimroth P, Hilbi H (July 1997). "Enzymic and genetic basis for bacterial growth on malonate". Molecular Microbiology. 25 (1): 3–10. doi:10.1046/j.1365-2958.1997.4611824.x. PMID 11902724.

External links

• Carboxybiotin+decarboxylase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)