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IGFBP5
بنى متوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معرفات بنك بيانات البروتين
	1BOE, 1H59
معرفات
أسماء بديلة	IGFBP5, IBP5, insulin like growth factor binding protein 5
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 146734 MGI: MGI:96440 HomoloGene: 56489 GeneCards: 3488
علم الوجود الجيني
وظائف جزيئية	• fibronectin binding; • insulin-like growth factor binding; • growth factor binding; • insulin-like growth factor I binding; • insulin-like growth factor II binding; • ‏GO:0001948، ‏GO:0016582 ربط بروتيني;
مكونات خلوية	• insulin-like growth factor ternary complex; • الفراغ خارج الخلية; • insulin-like growth factor binding protein complex; • endoplasmic reticulum lumen; • خارج خلوي;
عمليات حيوية	• negative regulation of smooth muscle cell proliferation; • negative regulation of translation; • positive regulation of protein kinase B signaling; • ‏GO:0007243 intracellular signal transduction; • negative regulation of growth; • glucose homeostasis; • حمل أنثوي; • ‏GO:1904579 cellular response to organic cyclic compound; • negative regulation of smooth muscle cell migration; • negative regulation of osteoblast differentiation; • regulation of glucose metabolic process; • negative regulation of cell migration; • positive regulation of insulin-like growth factor receptor signaling pathway; • regulation of cell growth; • osteoblast differentiation; • response to growth hormone; • glucose metabolic process; • negative regulation of insulin-like growth factor receptor signaling pathway; • hair follicle morphogenesis; • regulation of growth; • negative regulation of muscle tissue development; • striated muscle cell differentiation; • lung alveolus development; • negative regulation of skeletal muscle hypertrophy; • type B pancreatic cell proliferation; • cellular response to cAMP; • ‏GO:0072468 توصيل الإشارة; • mammary gland involution; • ‏GO:0010260 شيخوخة; • تعديل ما بعد الترجمة; • positive regulation of vascular associated smooth muscle cell proliferation; • positive regulation of vascular associated smooth muscle cell migration; • regulation of insulin-like growth factor receptor signaling pathway;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	; ; ; ;
	المزيد من بيانات التعبير المرجعية
تماثلات متسلسلة
	P24593
	Q07079
	NM_000599
	NM_010518
	NP_000590
	NP_034648
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

IGFBP5‏ (Insulin like growth factor binding protein 5) هوَ بروتين يُشَفر بواسطة جين IGFBP5 في الإنسان.^[1]^[2]

الوظيفة

الأهمية السريرية

المراجع

^ Kusakabe M، Ishikawa A، Ravinet M، Yoshida K، Makino T، Toyoda A، Fujiyama A، Kitano J (2017). "Genetic basis for variation in salinity tolerance between stickleback ecotypes". Molecular Ecology. ج. 26 ع. 1: 304–319. DOI:10.1111/mec.13875. PMID:27706866.
^ Allander SV، Larsson C، Ehrenborg E، Suwanichkul A، Weber G، Morris SL، Bajalica S، Kiefer MC، Luthman H، Powell DR (مايو 1994). "Characterization of the chromosomal gene and promoter for human insulin-like growth factor binding protein-5". J Biol Chem. ج. 269 ع. 14: 10891–8. PMID:7511611.

قراءة متعمقة

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Shimasaki S، Shimonaka M، Zhang HP، Ling N (1991). "Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human". J. Biol. Chem. ج. 266 ع. 16: 10646–53. PMID:1709938.
Ehrenborg E، Vilhelmsdotter S، Bajalica S، وآخرون (1991). "Structure and localization of the human insulin-like growth factor-binding protein 2 gene". Biochem. Biophys. Res. Commun. ج. 176 ع. 3: 1250–5. DOI:10.1016/0006-291X(91)90420-C. PMID:1710112.
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Kiefer MC، Ioh RS، Bauer DM، Zapf J (1991). "Molecular cloning of a new human insulin-like growth factor binding protein". Biochem. Biophys. Res. Commun. ج. 176 ع. 1: 219–25. DOI:10.1016/0006-291X(91)90912-Q. PMID:1850258.
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Kou K، James PL، Clemmons DR، وآخرون (1994). "Identification of two clusters of mouse insulin-like growth factor binding protein genes on chromosomes 1 and 11". Genomics. ج. 21 ع. 3: 653–5. DOI:10.1006/geno.1994.1329. PMID:7525452.
Andersson B، Wentland MA، Ricafrente JY، وآخرون (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. ج. 236 ع. 1: 107–13. DOI:10.1006/abio.1996.0138. PMID:8619474.
Yu W، Andersson B، Worley KC، وآخرون (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. ج. 7 ع. 4: 353–8. DOI:10.1101/gr.7.4.353. PMC:139146. PMID:9110174.
Nam TJ، Busby W، Clemmons DR (1997). "Insulin-like growth factor binding protein-5 binds to plasminogen activator inhibitor-I". Endocrinology. ج. 138 ع. 7: 2972–8. DOI:10.1210/en.138.7.2972. PMID:9202242.
Twigg SM، Baxter RC (1998). "Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit". J. Biol. Chem. ج. 273 ع. 11: 6074–9. DOI:10.1074/jbc.273.11.6074. PMID:9497324.{{استشهاد بدورية محكمة}}: صيانة الاستشهاد: دوي مجاني غير معلم (link)
Zheng B، Clarke JB، Busby WH، وآخرون (1998). "Insulin-like growth factor-binding protein-5 is cleaved by physiological concentrations of thrombin". Endocrinology. ج. 139 ع. 4: 1708–14. DOI:10.1210/en.139.4.1708. PMID:9528953.
Twigg SM، Kiefer MC، Zapf J، Baxter RC (1998). "Insulin-like growth factor-binding protein 5 complexes with the acid-labile subunit. Role of the carboxyl-terminal domain". J. Biol. Chem. ج. 273 ع. 44: 28791–8. DOI:10.1074/jbc.273.44.28791. PMID:9786878.{{استشهاد بدورية محكمة}}: صيانة الاستشهاد: دوي مجاني غير معلم (link)
Kalus W، Zweckstetter M، Renner C، وآخرون (1999). "Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions". EMBO J. ج. 17 ع. 22: 6558–72. DOI:10.1093/emboj/17.22.6558. PMC:1171003. PMID:9822601.
Ständker L، Wobst P، Mark S، Forssmann WG (1999). "Isolation and characterization of circulating 13-kDa C-terminal fragments of human insulin-like growth factor binding protein-5". FEBS Lett. ج. 441 ع. 2: 281–6. DOI:10.1016/S0014-5793(98)01497-5. PMID:9883900.
Kecha O، Martens H، Franchimont N، وآخرون (1999). "Characterization of the insulin-like growth factor axis in the human thymus". J. Neuroendocrinol. ج. 11 ع. 6: 435–40. DOI:10.1046/j.1365-2826.1999.00343.x. PMID:10336724.