CCL5

CCL5
Struktur yang tersedia PDB Pencarian Ortolog: PDBe RCSB Daftar kode id PDB 1B3A, 1EQT, 1HRJ, 1RTN, 1RTO, 1U4L, 1U4M, 1U4P, 1U4R, 2L9H, 2VXW, 5CMD, 5DNF, 5COY
Pengidentifikasi
Alias	CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP, C-C motif chemokine ligand 5
ID eksternal	OMIM: 187011 MGI: 98262 HomoloGene: 2244 GeneCards: CCL5
Lokasi gen (Tikus) Kr. Kromosom 11 (tikus)[1] Pita 11 C|11 50.66 cM Awal 83,416,604 bp[1] Akhir 83,421,344 bp[1]
Pola ekspresi RNA Referensi data ekspresi selengkapnya
Ontologi gen Fungsi molekuler • CCR5 chemokine receptor binding • receptor signaling protein tyrosine kinase activator activity • chemokine activity • protein self-association • CCR4 chemokine receptor binding • phosphatidylinositol phospholipase C activity • protein kinase activity • cytokine activity • CCR1 chemokine receptor binding • phospholipase activator activity • chemokine receptor binding • homodimerisasi protein • chemokine receptor antagonist activity • GO:0001948, GO:0016582 Ikatan protein plasma • chemoattractant activity • pengikatan protein identik • CCR chemokine receptor binding Komponen seluler • sitoplasma • extracellular region • extracellular space Proses biologis • leukocyte cell-cell adhesion • positive regulation of cell-cell adhesion mediated by integrin • regulation of T cell activation • positive regulation of smooth muscle cell migration • activation of phospholipase D activity • negative regulation of viral genome replication • positive regulation of ERK1 and ERK2 cascade • positive regulation of innate immune response • cellular response to interferon-gamma • positive regulation of macrophage chemotaxis • calcium ion transport • Eksositosis • positive regulation of calcium ion transport • response to cytokine • regulation of insulin secretion • chemokine-mediated signaling pathway • positive regulation of cellular biosynthetic process • response to virus • positive regulation of monocyte chemotaxis • cellular response to fibroblast growth factor stimulus • neutrophil chemotaxis • response to tumor necrosis factor • negative regulation of T cell apoptotic process • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • negative regulation of macrophage apoptotic process • positive regulation of T cell proliferation • positive regulation of phosphorylation • inflammatory response • positive regulation of translational initiation • response to toxic substance • positive regulation of epithelial cell proliferation • positive regulation of tyrosine phosphorylation of STAT protein • GO:1904579 cellular response to organic cyclic compound • cellular calcium ion homeostasis • protein tetramerization • chemotaxis • positive regulation of homotypic cell-cell adhesion • cellular response to interleukin-1 • GO:0046730, GO:0046737, GO:0046738, GO:0046736 respons imun • positive regulation of viral genome replication • positive regulation of receptor signaling pathway via JAK-STAT • lipopolysaccharide-mediated signaling pathway • positive regulation of T cell migration • regulation of chronic inflammatory response • positive regulation of smooth muscle cell proliferation • neutrophil activation • protein kinase B signaling • positive regulation of cell migration • positive regulation of natural killer cell chemotaxis • cell-cell signaling • eosinophil chemotaxis • dendritic cell chemotaxis • MAPK cascade • macrophage chemotaxis • positive regulation of T cell chemotaxis • regulation of neuron death • positive regulation of phosphatidylinositol 3-kinase signaling • negative regulation of G protein-coupled receptor signaling pathway • positive regulation of T cell apoptotic process • positive regulation of cell adhesion • negative regulation of chemokine-mediated signaling pathway • monocyte chemotaxis • positive chemotaxis • positive regulation of protein tyrosine kinase activity • cellular response to tumor necrosis factor • positive regulation of activation of Janus kinase activity • regulation of signaling receptor activity • G protein-coupled receptor signaling pathway • cytokine-mediated signaling pathway • lymphocyte chemotaxis Sumber:Amigo / QuickGO
Ortolog
Spesies	Manusia	Tikus
Entrez	6352	20304
Ensembl	ENSG00000271503 ENSG00000274233	ENSMUSG00000035042
UniProt	P13501	P30882
RefSeq (mRNA)	NM_002985 NM_001278736	NM_013653
RefSeq (protein)	NP_001265665 NP_002976	NP_038681
Lokasi (UCSC)	n/a	Chr 11: 83.42 – 83.42 Mb
Pencarian PubMed	[2]	[3]
Wikidata
Lihat/Sunting Manusia Lihat/Sunting Tikus

CCL5 (bahasa Inggris: CCL5, Regulated upon Activation, Normal T-cell Expressed, and Secreted (RANTES)) adalah kemokina peptida yang dikodikasi pada gen CCL5^[4] pada kromosom 17.^[5]

Protein CCL5 mempunyai massa 8 kDa, merupakan sitokina kemotaktik bagi sel T, eosinofil dan basofil.

Bersama dengan hormon IL-2 dan IFN-γ yang disekresi oleh sel T, CCL5 menginduksi proliferasi dan aktivasi beberapa sel NK untuk menjadi sel CHAK (bahasa Inggris: CC-Chemokine-activated killer cell).^[6]

CCL5 yang disekresi oleh sel T CD8 dikenal sebagai faktor penekan virus HIV.

Rujukan

1. GRCm38: Ensembl release 89: ENSMUSG00000035042 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Donlon TA, Krensky AM, Wallace MR, Collins FS, Lovett M, Clayberger C (1990). "Localization of a human T-cell-specific gene, RANTES (D17S136E), to chromosome 17q11.2-q12". Genomics. 6 (3): 548–53. doi:10.1016/0888-7543(90)90485-D. PMID 1691736.
5. Donlon et al. Localization of a human T-cell-specific gene, CCL5 (D17S136E), to chromosome 17q11.2-q12. Genomics 5: 548-553, 1990. PMID 1691736
6. Maghazachi et al., CC chemokines induce the generation of killer cells from CD56+ cells, Eur J Immunol. 1996, 26:315-9. PMID 8617297