庚酸雄甾醇酮
庚酸雄甾醇酮 商品名 Anaboleen Depot 其他名稱 Stanolone enanthate; Dihydrotestosterone enanthate; DHT enanthate; Dihydrotestosterone heptanoate; DHTH; 5α-Androstan-17β-ol-3-one 17β-heptanoate 给药途径 Intramuscular injection 藥物類別 Androgen ; Anabolic steroid ; Androgen ester
[(5S ,8R ,9S ,10S ,13S ,14S ,17S )-10,13-dimethyl-3-oxo-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a ]phenanthren-17-yl] heptanoate
CAS号 33776-88-4 PubChem CID ChemSpider UNII CompTox Dashboard (EPA ) 化学式 C 26 H 42 O 3 摩尔质量 402.62 g·mol−1 3D模型(JSmol )
CCCCCCC(=O)O[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@@H]4[C@@]3(CCC(=O)C4)C)C
InChI=1S/C26H42O3/c1-4-5-6-7-8-24(28)29-23-12-11-21-20-10-9-18-17-19(27)13-15-25(18,2)22(20)14-16-26(21,23)3/h18,20-23H,4-17H2,1-3H3/t18-,20-,21-,22-,23-,25-,26-/m0/s1
Key:DDYHAKNCTGGYOK-LVYWIKMTSA-N
庚酸雄甾醇酮 (英语:Androstanolone enanthate),也称为庚酸雄诺龙 或庚酸二氢睾酮 ,是一种合成的雄激素 和合成代谢类固醇 和二氢睾酮 酯。[ 1] [ 2] 它用作注射 剂,并作为雄甾醇酮 (二氢睾酮 )的前体药物 。该药物已被研究并发现可有效治疗男孩和成年男性的男性乳房发育症 。[ 3] [ 4] [ 5] 已对庚酸雄甾醇酮的药理学 进行了研究。[ 6] [ 7]
参见
参考资料
^ J. Elks. The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies . Springer. 14 November 2014: 640–. ISBN 978-1-4757-2085-3 .
^ I.K. Morton; Judith M. Hall. Concise Dictionary of Pharmacological Agents: Properties and Synonyms . Springer Science & Business Media. 6 December 2012: 261–. ISBN 978-94-011-4439-1 .
^ Swerdloff, Ronald S.; Wang, Christina. Dihydrotestosterone: A rationale for its use as a non-aromatizable androgen replacement therapeutic agent. Baillière's Clinical Endocrinology and Metabolism. 1998, 12 (3): 501–506. ISSN 0950-351X . PMID 10332569 . doi:10.1016/S0950-351X(98)80267-X .
^ Eberle AJ, Sparrow JT, Keenan BS. Treatment of persistent pubertal gynecomastia with dihydrotestosterone heptanoate . J. Pediatr. 1986, 109 (1): 144–9. PMID 3088241 . doi:10.1016/s0022-3476(86)80596-0 .
^ Swerdloff, Ronald S.; Dudley, Robert E.; Page, Stephanie T.; Wang, Christina; Salameh, Wael A. Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels . Endocrine Reviews. 2017, 38 (3): 220–254. ISSN 0163-769X . PMC 6459338 . PMID 28472278 . doi:10.1210/er.2016-1067 .
^ Keenan, Bruce S.; Eberle, Andrea J.; Sparrow, James T.; Greger, Nancy G.; Panko, Walter B. Dihydrotestosterone Heptanoate: Synthesis, Pharmacokinetics, and Effects on Hypothalamic-Pituitary-Testicular Function. The Journal of Clinical Endocrinology & Metabolism. 1987, 64 (3): 557–562. ISSN 0021-972X . PMID 3546348 . doi:10.1210/jcem-64-3-557 .
^ Coutts SB, Kicman AT, Hurst DT, Cowan DA. Intramuscular administration of 5 alpha-dihydrotestosterone heptanoate: changes in urinary hormone profile . Clin. Chem. November 1997, 43 (11): 2091–8. PMID 9365393 . doi:10.1093/clinchem/43.11.2091 .
激动药 抗雄激素
AR 受体拮抗剂 类固醇生成抑制剂
抗促性腺激素
D2 receptor antagonist s (prolactin releaser s) (e.g., domperidone , 甲氧氯普胺 , risperidone , haloperidol , 氯丙嗪 , sulpiride )
Estrogen s (e.g., bifluranol , 己烯雌酚 , 雌二醇 , estradiol ester s, ethinylestradiol , ethinylestradiol sulfonate , paroxypropione )
GnRH agonist s (e.g., leuprorelin )
GnRH antagonist s (e.g., cetrorelix )
Progestogen s (incl., chlormadinone acetate , 醋酸环丙孕酮 , hydroxyprogesterone caproate , gestonorone caproate , medroxyprogesterone acetate , megestrol acetate )
其它