華盛頓大學蛋白質設計研究所(IPD)就目前的進展進行了報告。該消息證實,Rosetta @ home 一直在處理冠狀病毒的臭名昭著的棘突蛋白(spike protein),並透露它已經能夠“準確預測重要的冠狀病毒蛋白的標度結構可以在實驗室中檢測到。IPD還強調了這項研究的一些可能的應用。他們寫道:“掌握了這些知識後,蛋白質設計研究所的研究人員現在正在努力創造新的蛋白質來中和冠狀病毒。如果成功,這些抗病毒蛋白將粘附在SARS-CoV-2穗蛋白上,從而防止病毒顆粒感染健康細胞。” 此外,IPD透露,美國國立衛生研究院和華盛頓大學的研究同事正在使用 Rosetta @ home 的結果來生產候選疫苗-其中一些已經在小鼠身上進行了測試。[41]
RosettaDesign是基于Rosetta的一个蛋白质设计工具。它始于2000年对蛋白质G的折叠路径的一项研究。[45]2002年,RosettaDesign被用来设计TOP7。TOP7是一种93个氨基酸长度的α/β型蛋白质,具有在自然界中尚未被发现的整体折叠结构。这一全新的结构由Rosetta预测,与X射线晶体学确定的结构的之间的RMSD在1.2埃范围内,是一个精度极高的结构预测。[46]Rosetta和RosettaDesign最早设计和精确预测出这一长度的新型蛋白质,受到广泛的认可。他们2003年在《科学》杂志上发表的相关论文已被270多篇论文引用。[47]这项研究的显著成果TOP7被选为蛋白质数据库2005年10月的“月度分子”(Molecule of the Month)。[48]这项预测与其X射线晶体学结构的叠合被包含在Rosetta@home的logo设计中。[16]曾在贝克实验室当博士后、现任北卡罗来纳大学教堂山分校助理教授的布赖恩·库尔曼[49]提供了RosettaDesign的在线服务。[50]
预测的蛋白质结构被提交到CASP实验的用户,也在相关的学术出版物中被致谢。[79]而预测出指定工作单元最低能量结构的用户及其所在队伍则会在Rosetta@home的主页上被列为“当日预测者”(Predictor of the Day)。[80]每天还有一名随机选出的用户会被列在主页上,成为“当日用户”(User of the Day)。[81]
جمهورية صوماليلاند (بالصومالية: Jamhuuriyadda Soomaaliland) صوماليلاندعلم أرض الصومال صوماليلاندشعار أرض الصومال الشعار الوطنيلا إله إلا الله محمد رسول الله النشيد: حياة طويلة مع السلامSamo ku waarLong Life with Peace الأرض والسكان إحداثيات 9°48′N 46°12′E / 9.8°N 46.2°E / 9.8; 46.2 [1]…
University Foundation Logo The Belgian University Foundation (French: Fondation Universitaire; Dutch: Universitaire Stichting) was founded in 1920. The goal of the Foundation, as was put forward by Emile Francqui, is to promote scientific activity at Belgian universities. Goals To provide grants and study loans to students from less privileged families. To help university research centres and laboratories to attract young researchers. To stimulate contacts and collaboration between the different…
Duta Besar Jepang untuk IndonesiaPetahanaKanasugi Kenjisejak 2021Dibentukca. 1959Pejabat pertamaTakio OdaSitus webid.emb-japan.go.jp/itprtop_id/index.html Berikut adalah daftar duta besar Jepang untuk Republik Indonesia. Nama Mulai tugas Kredensial Selesai tugas Ref. Takio Oda ca. 1959 [1] Akira Nishiyama ca. 1962 [2] Akira Nishiyama ca. 1967 [3] Masao Yagi 18 Januari 1969 [4] Hiroto Tanaka 9 September 1972 [4] Ryozo Sunobe 9 Januari 1974 [4] …
Üzeyir Hacıbəyov (1945) Üzeyir Əbdul Hüseyn oğlu Hacıbəyov (russisch Узеир Абдул-Гусейн оглы Гаджибеков/ عزیر حاجیبیوو / Useir Abdul-Gussein ogly Gadschibekow; * 5. Septemberjul. / 17. September 1885greg. in Ağcabədi; † 23. November 1948 in Baku) war ein sowjetischer und aserbaidschanischer Komponist, Musikwissenschaftler, Publizist, Dramaturg und Pädagoge. Er gilt als der Gründer der modernen aserbaidschanischen Musik un…
Overview of Mexico's economic history Part of a series on the History of Mexico Pre-Columbian The New Spain Spanish-Aztec War Viceroyalty of New Spain War of Independence First Empire First Republic Centralist Republic Texas Revolution Pastry War Mexican–American War Second Federal Republic La Reforma Reform War French intervention 1864–1928 Second Mexican Empire Restored Republic The Porfiriato Revolution La decena trágica Plan of Guadalupe Tampico Affair Occupation of Veracruz Cristero Wa…
Derechos LGBT en Estados UnidosBanderaEscudo HomosexualidadEs legal Desde 26 de junio de 2003 a nivel nacional (Muchos estados del país legalizaron la homosexualidad bastantes años antes, sin embargo, en 2003 algunos estados seguían teniendo vigentes leyes que castigaban la homosexualidad, cosa que cambio el 26 de junio de ese mismo año, cuando la Corte Suprema anulo dichas leyes y legalizo la homosexualidad en todo el territorio estadounidense)Protección legal contra la discriminaciónLabo…
2000 compilation album by various artistsCaroline Now!: The Songs of Brian Wilson and the Beach BoysCompilation album by various artistsReleasedAugust 4, 2000 (2000-08-04)Recorded1998 (1998)–2000 (2000)GenreIndie rockLength77:14LabelMarinaProducerStefan Kassel, Frank Lähnemann Caroline Now!: The Songs of Brian Wilson and the Beach Boys is a 2000 tribute album devoted to songs by the Beach Boys, consisting of cover versions recorded by independent artists.[…
Romanian nuclear energy company This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Nuclearelectrica – news · newspapers · books · scholar · JSTOR (March 2022) (Learn how and when to remove this template message) Nuclearelectrica S.A.TypeMajority state owned company - 82,49% owned by the Romania state through the M…
Fictional character in Roald Dahl novels This article is about the fictional character. For the film sometimes abbreviated as Willy Wonka, see Willy Wonka & the Chocolate Factory. For other uses, see Willy Wonka (disambiguation). Fictional character Willy WonkaCharlie and the Chocolate Factory characterGene Wilder as Willy Wonka in Willy Wonka & the Chocolate Factory (1971)First appearanceCharlie and the Chocolate Factory (1964)Created byRoald DahlPortrayed by Gene Wilder (1971) Johnny D…
Pour les articles homonymes, voir Villaverde. Cet article est une ébauche concernant un footballeur uruguayen. Vous pouvez partager vos connaissances en l’améliorant (comment ?) selon les recommandations des projets correspondants. Ramón Alberto Villaverde Biographie Nationalité Uruguayen Naissance 16 mars 1930 Montevideo Décès 15 septembre 1986 (à 56 ans) Barcelone Poste Attaquant Parcours senior1 SaisonsClubsM (B.)1949-1950 Liverpool FC1950-1952 Cúcuta Deportivo85 …
Jacques Schwarz-Bart Jacques Schwarz-Bart (Brother Jacques, * 22. Dezember 1962 in Les Abymes/Pointe-à-Pitre auf Guadeloupe) ist ein in den USA lebender Jazz-Saxophonist. Inhaltsverzeichnis 1 Leben und Wirken 2 Diskographische Hinweise 3 Weblinks 4 Einzelnachweise Leben und Wirken Schwarz-Bart, Sohn des Schriftstellerehepaars Simone und André Schwarz-Bart, wuchs mit karibischer Musik auf. Im Alter von sechs Jahren lernte er in der Schweiz Jazzmusik kennen und begann elfjährig mit Lausanner Ja…
Gambar seorang pengacara dalam pengacaraan. Acara adalah kata dalam bahasa Indonesia untuk mengungkapakan agenda, hal atau pokok masalah yang akan dibahas dalam rapat atau musyawarah.[1] Acara sebagai Kata Kerja Beracara berarti memakai acara atau memeriksa dan mempertimbangkan perkara (di pengadilan).[2] Mengacara berarti menjatuhkan keputusan hukum.[2] Mengacarakan berarti mencantumkan di dalam acara, menjadikan acara.[2] Acara sebagai Kata Benda Acara sebagai k…
Корнієнко Ігор ОлександровичНародився 15 березня 1964(1964-03-15)Новоград-Волинський, Житомирська область, Українська РСР, СРСРПомер 6 січня 1995(1995-01-06) (30 років)Грозний, РосіяПоховання ВолгоградУчасник Перша чеченська війнаВійськове звання майорНагороди У Вікіпедії є статті про …
Not to be confused with Health in Estonia. This article provides insufficient context for those unfamiliar with the subject. Please help improve the article by providing more context for the reader. (March 2019) (Learn how and when to remove this template message) Development of life expectancy in Estonia Healthcare in Estonia is supervised by the Ministry of Social Affairs and funded by general taxation through the National Health Service. The service is administered by the Estonian Health Insu…
Not to be confused with Thomas King (merchant). Thomas KingBornc. 1740Diedc. 1824 (aged 83–84)NationalityBritishOccupation(s)Slave trader and merchantBoard member ofCamden, Calvert and KingSpouseSarahChildren6ParentNewark King Thomas King (c. 1740 – c. 1824) was a British slave-trader and partner in the firm of Camden, Calvert and King. His early career was at sea in a variety of vessels involved in the slave trade in the Caribbean and West Africa in the 1760s. He probably met …
Nama ini menggunakan cara penamaan Spanyol: nama keluarga pertama atau paternalnya adalah Sonnenholzner dan nama keluarga kedua atau maternalnya adalah Sper. Otto SonnenholznerWakil Presiden Ekuador ke-50Masa jabatan11 Desember 2018 – 10 Juli 2020PresidenLenín MorenoPendahuluMaría Alejandra VicuñaPenggantiMaría Alejandra Muñoz Informasi pribadiLahirOtto Ramón Sonnenholzner Sper19 Maret 1983 (umur 40)Guayaquil, EkuadorPartai politikIndependenSuami/istriClaudia Salem Bar…
Shopping centre in Kowloon City, Hong Kong Kowloon City Plaza (KCP)The main entrance of Kowloon City PlazaLocation128 Carpenter Road,Kowloon City, Kowloon,Hong KongOpening date1993; 30 years ago (1993)DeveloperPaliburg HoldingsArchitectAedas Architects (for renovation of 2005-06)[1]No. of stores and servicesover 70Total retail floor area640,000 sq ft (59,000 m2)No. of floors10 floorsParking400 spacesWebsiteKCP Kowloon City PlazaTraditional Chinese九…
Southside Community CentreFormer namesNicolson Street Church of Scotland (1929–1969)Nicolson Street United Free Church (1900–1929)Nicolson Street United Presbyterian Church (1847–1900)Nicolson Street United Secession Church (1820–1847)Dr Jamieson's Meeting-HouseAlternative namesSouthside Community Education CentreZoo SouthsideGeneral informationStatusActiveArchitectural stylePerpendicular GothicGothic revivalAddress117 Nicolson StreetEdinburghEH8 9ERTown or cityEdinburghCountryScotland, …