若空氣栓塞出現在動脈,稱為動脈空氣栓塞(arterial gas embolism,AGE)。動脈空氣栓塞比靜脈空氣栓塞要嚴重的多,因為會直接影響身體某個部位的供血。動脈空氣栓塞的症狀和其影響供血的部位有關,若影響到大腦或是心臟,也可能造成中風或是心肌梗死[8]。隨著部位不同,會產生動脈空氣栓塞症狀的氣體量也會不同,在腦血管2 mL的空氣就可以致命,而在冠狀動脈中,0.5 mL的空氣就會造成心搏停止[9][10]。
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^Pearson, RR; Goad, RF. Delayed cerebral edema complicating cerebral arterial gas embolism: case histories.. Undersea biomedical research. December 1982, 9 (4): 283–96. PMID 7168093.