Varisella zoster virüs

Varicella zoster virüsü

Varisella zoster virüsü (VZV) insanları enfekte ettiği bilinen sekiz grup Herpes virüsünden birisidir. Genellikle çocuklarda suçiçeğine, yetişkinlerde Herpes zoster (zona) hastalığına neden olur.[1] "Su çiçeği virüsü, zona virüsü, İnsan Herpes Virüsü tip 3 (HHV-3), Varisella-zoster virüsü" gibi birçok isimlendirmesi vardır.

Primer VZV enfeksiyonu suçiçeği hastalığı oluşturur. Bu hastalığın komplikasyonları sonucu nadiren ensefalit ya da zatürre görülür. Suçiçeğinin klinik belirtileri kaybolmuş olsa bile VZV enfekte kişinin sinir sisteminde özellikle trigeminal ve dorsal kök gangliyonlarında atıl olarak kalır (virüs latensi).[2] Vakaların yaklaşık % 10-20 sinde VZV, bu kişilerin sonraki yaşamlarında reaktive olur ve zona olarak bilinen hastalığı oluşturur.

Tedavi

Virüs özellikle sodyum hipoklorit içeren dezenfektanlara çok duyarlıdır. İnsanlarda suçiçeği için asiklovir, zona için famsiklovir, valasiklovir kullanılır. Vidarabine, VZV immünglobulin de tedavide kullanılır.

Kaynakça

  1. ^ "Varisella zoster virüs enfeksiyonları" (PDF). Ankara edu.tr. 2001. 10 Temmuz 2012 tarihinde kaynağından arşivlendi (PDF). Erişim tarihi: 25 Haziran 2012. 
  2. ^ Steiner I (2007). "The neurotropic herpes viruses: herpes simplex and varicella-zoster". Lancet Neurol. 6 (11). ss. 1015-28. doi:10.1016/S1474-4422(07)70267-3. PMID 17945155. 

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