SERPINB4
เซอร์ปิน บี4 (อังกฤษ : Serpin B4 หรือ SERPINB4, Squamous cell carcinoma antigen-2; SCCA2) เป็นโปรตีน ของมนุษย์ และเป็นโปรตีนสมาชิกลำดับที่ 4 ในเคลด บีของมหาวงศ์ เซอร์ปิน (Serpin family B member 4) ถูกถอดรหัสได้จากยีน SERPINB4 บนโครโมโซมคู่ที่ 18 [ 5] [ 6] [ 7]
↑ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000206073 – Ensembl , May 2017↑ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000044594 – Ensembl , May 2017↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .↑ Schneider SS, Schick C, Fish KE, Miller E, Pena JC, Treter SD, Hui SM, Silverman GA (May 1995). "A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene" . Proc Natl Acad Sci U S A . 92 (8): 3147–51. doi :10.1073/pnas.92.8.3147 . PMC 42122 PMID 7724531 . ↑ Sakata Y, Arima K, Takai T, Sakurai W, Masumoto K, Yuyama N, Suminami Y, Kishi F, Yamashita T, Kato T, Ogawa H, Fujimoto K, Matsuo Y, Sugita Y, Izuhara K (Feb 2004). "The squamous cell carcinoma antigen 2 inhibits the cysteine proteinase activity of a major mite allergen, Der p 1" . J Biol Chem . 279 (7): 5081–7. doi :10.1074/jbc.M311585200 PMID 14630915 . ↑ "Entrez Gene: SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4" .
Barnes RC, Worrall DM (1995). "Identification of a novel human serpin gene; cloning sequencing and expression of leupin". FEBS Letters . 373 (1): 61–5. doi :10.1016/0014-5793(95)01015-7 . PMID 7589435 . S2CID 26092255 . Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806. doi :10.1101/gr.6.9.791 PMID 8889548 . Bartuski AJ, Kamachi Y, Schick C, และคณะ (1999). "A murine ortholog of the human serpin SCCA2 maps to chromosome 1 and inhibits chymotrypsin-like serine proteinases". Genomics . 54 (2): 297–306. doi :10.1006/geno.1998.5586 . PMID 9828132 . Sakaguchi Y, Kishi F, Murakami A, และคณะ (1999). "Structural analysis of human SCC antigen 2 promoter". Biochim. Biophys. Acta . 1444 (1): 111–6. doi :10.1016/s0167-4781(98)00259-0 . PMID 9931463 . Cataltepe S, Gornstein ER, Schick C, และคณะ (2000). "Co-expression of the squamous cell carcinoma antigens 1 and 2 in normal adult human tissues and squamous cell carcinomas" . J. Histochem. Cytochem . 48 (1): 113–22. doi :10.1177/002215540004800112 PMID 10653592 . Luke C, Schick C, Tsu C, และคณะ (2000). "Simple modifications of the serpin reactive site loop convert SCCA2 into a cysteine proteinase inhibitor: a critical role for the P3' proline in facilitating RSL cleavage". Biochemistry . 39 (24): 7081–91. doi :10.1021/bi000050g . PMID 10852705 . Uemura Y, Pak SC, Luke C, และคณะ (2000). "Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells". Int. J. Cancer . 89 (4): 368–77. doi :10.1002/1097-0215(20000720)89:4<368::AID-IJC9>3.0.CO;2-6 . PMID 10956412 . Hamada K, Shinomiya H, Asano Y, และคณะ (2001). "Molecular cloning of human squamous cell carcinoma antigen 1 gene and characterization of its promoter". Biochim. Biophys. Acta . 1518 (1–2): 124–31. doi :10.1016/s0167-4781(01)00174-9 . PMID 11267667 . Takeda A, Kajiya A, Iwasawa A, และคณะ (2003). "Aberrant expression of serpin squamous cell carcinoma antigen 2 in human tumor tissues and cell lines: evidence of protection from tumor necrosis factor-mediated apoptosis". Biol. Chem . 383 (7–8): 1231–6. doi :10.1515/BC.2002.136 . PMID 12437110 . S2CID 23972588 . Strausberg RL, Feingold EA, Grouse LH, และคณะ (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 PMID 12477932 . Gariboldi M, Peissel B, Fabbri A, และคณะ (2003). "SCCA2-like serpins mediate genetic predisposition to skin tumors" . Cancer Res . 63 (8): 1871–5. PMID 12702576 . Pontisso P, Calabrese F, Benvegnù L, และคณะ (2004). "Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma" . Br. J. Cancer . 90 (4): 833–7. doi :10.1038/sj.bjc.6601543 . PMC 2410161 PMID 14970861 . Gerhard DS, Wagner L, Feingold EA, และคณะ (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Ray R, Choi M, Zhang Z, และคณะ (2005). "Uteroglobin suppresses SCCA gene expression associated with allergic asthma" . J. Biol. Chem . 280 (11): 9761–4. doi :10.1074/jbc.C400581200 PMID 15677460 . Rual JF, Venkatesan K, Hao T, และคณะ (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Sueoka K, Nawata S, Nakagawa T, และคณะ (2005). "Tumor-associated serpin, squamous cell carcinoma antigen stimulates matrix metalloproteinase-9 production in cervical squamous cell carcinoma cell lines". Int. J. Oncol . 27 (5): 1345–53. doi :10.3892/ijo.27.5.1345 . PMID 16211231 . Kimura K, Wakamatsu A, Suzuki Y, และคณะ (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes" . Genome Research . 16 (1): 55–65. doi :10.1101/gr.4039406 . PMC 1356129 PMID 16344560 . Katagiri C, Nakanishi J, Kadoya K, Hibino T (2006). "Serpin squamous cell carcinoma antigen inhibits UV-induced apoptosis via suppression of c-JUN NH2-terminal kinase" . J. Cell Biol . 172 (7): 983–90. doi :10.1083/jcb.200508064 . PMC 2063756 PMID 16549498 .
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