Ubikvitin-kalmodulinska ligaza

Ubikvitin-kalmodulinska ligaza
Identifikatori
EC broj	6.3.2.21
CAS broj	119632-60-9
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC članci PubMed članci NCBI proteini

Ubikvitin-kalmodulinska ligaza (EC 6.3.2.21, ubikvitil-kalmodulinska sintaza, ubikvitin-kalmodulinska sintetaza, ubikvitil-kalmodulinska sintetaza, uCaM-sintetaza) je enzim sa sistematskim imenom kalmodulin:ubikvitin ligaza (formira AMP).^[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju

n ATP + kalmodulin + n ubikvitin ${\displaystyle \rightleftharpoons }$ n AMP + n difosfat + (ubikvitin)N-kalmodulin

Ovaj enzim je specifičan za Ca²⁺-kalmodulin kod kičmenjaka.

Reference

1. Jennissen, H.P. & Laub, M. (1988). „Ubiquitin-calmodulin conjugating activity from cardiac muscle”. Biol. Chem. Hoppe-Seyler. 369: 1325—1330. PMID 2853950. 
2. Ziegenhagen, R. & Jennissen, H.P. (1988). „Multiple ubiquitination of vertebrate calmodulin by reticulocyte lysate and inhibition of calmodulin conjugation by phosphorylase kinase”. Biol. Chem. Hoppe-Seyler. 369: 1317—1324. PMID 2853949. 

Literatura

• Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036. 
• Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097. 

Spoljašnje veze

• Ubiquitin---calmodulin+ligase на US National Library of Medicine Medical Subject Headings (MeSH)