Leukotrien-E4 20-monooksigenaza

Leukotrien-E4 20-monooksigenaza
Identifikatori
EC broj	1.14.13.34
CAS broj	111940-51-3
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC članci PubMed članci NCBI proteini

Leukotrien-E4 20-monooksigenaza (EC 1.14.13.34, leukotrien-E4 omega-hidroksilaza) je enzim sa sistematskim imenom (7E,9E,11Z,14Z)-(5S,6R)-6-(cistein-S-il)-5-hidroksiikosa-7,9,11,14-tetraenoat,NADPH:kiseonik oksidoreduktaza (20-hidroksilacija).^[1] Ovaj enzim katalizuje sledeću hemijsku reakciju

(7E,9E,11Z,14Z)-(5S,6R)-6-(cistein-S-il)-5-hidroksiikosa-7,9,11,14-tetraenoat + NADPH + H⁺ + O₂ ${\displaystyle \rightleftharpoons }$ 20-hidroksileukotrien E4 + NADP⁺ +H₂O

Ovaj enzim takođe deluje na N-acetil-leukotrien E4, mada sporo.

Reference

1. Örning, L. (1987). „ω-Oxidation of cysteine-containing leukotrienes by rat-liver microsomes. Isolation and characterization of ω-hydroxy and ω-carboxy metabolites of leukotriene E₄ and N-acetylleukotriene E₄”. Eur. J. Biochem. 170: 77—85. PMID 2826163. CS1 одржавање: Вишеструка имена: списак аутора (веза)

Literatura

• Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036. 
• Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097. 
• William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605. 

Spoljašnje veze

• Leukotriene-E4+20-monooxygenase на US National Library of Medicine Medical Subject Headings (MeSH)