Inozitol-1,4-bisfosfatna 1-fosfataza

Inozitol-1,4-bisfosfatna 1-fosfataza
Identifikatori
EC broj	3.1.3.57
CAS broj	111694-13-4&title= 111070-17-8, 111694-13-4
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC članci PubMed članci NCBI proteini

Inozitol-1,4-bisfosfatna 1-fosfataza (EC 3.1.3.57, inozitol-polifosfatna 1-fosfataza) je enzim sa sistematskim imenom 1D-mio-inozitol-1,4-bisfosfat 1-fosfohidrolaza.^[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

1D-mio-inozitol 1,4-bisfosfat + H₂O ${\displaystyle \rightleftharpoons }$ 1D-mio-inozitol 4-fosfat + fosfat

Ovaj enzim deluje na inozitol 1,4-bisfosfat i inozitol 1,3,4-trisfosfat (formira inozitol 3,4-bisfosfat) sa sličnim V_max vrednostima za oba supstrata.

Reference

1. Berridge, M.J., Dawson, R.M.C., Downes, C.P., Heslop, J.P. and Irvine, R.F. (1983). „Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides”. Biochem. J. 212: 473—482. PMID 6309146. CS1 одржавање: Вишеструка имена: списак аутора (веза)
2. Connolly, T.M., Bansal, V.S., Bross, T.E., Irvine, R.F. and Majerus, P.W. (1987). „The metabolism of tris- and tetraphosphates of inositol by 5-phosphomonoesterase and 3-kinase enzymes”. J. Biol. Chem. 262: 2146—2149. PMID 3029066. CS1 одржавање: Вишеструка имена: списак аутора (веза)
3. Inhorn, R.C. & Majerus, P.W. (1987). „Inositol polyphosphate 1-phosphatase from calf brain. Purification and inhibition by Li⁺, Ca²⁺, and Mn²⁺”. J. Biol. Chem. 262: 15946—15952. PMID 2824473. 

Literatura

• Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036. 
• Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097. 
• William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605. 

Spoljašnje veze

• Inositol-1,4-bisphosphate+1-phosphatase на US National Library of Medicine Medical Subject Headings (MeSH)