Hidroliza rastvornog epoksida

Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Hidroliza rastvornog epoksida
Hidroliza rastvornog epoksida
Identifikatori
EC broj	3.3.2.10
CAS broj	9048-63-9
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Hidroliza rastvornog epoksida (EC 3.3.2.10, epoksidna hidraza, epoksidna hidrataza, aren-oksidna hidrataza, aril epoksidna hidraza, trans-stilben oksidna hidrolaza, sEH, citozol epoksidna hidrolaza) je enzim sa sistematskim imenom epoksidna hidrolaza.^[1]^[2]^[3]^[4]^[5]^[6]^[7]^[8]^[9]^[10] Ovaj enzim katalizuje sledeću hemijsku reakciju

epoksid + H₂O

\rightleftharpoons

glikol

Ovaj enzim katalizuje hidrolizu trans-supstituisanih epoksida, poput trans-stilbene oksida, kao i raznih alifatičnih epoksida izvedenih iz metabolizma masnih kiselina.

Reference

^ Newman, J.W., Morisseau, C., Harris, T.R. and Hammock, B.D. (2003). „The soluble epoxide hydrolase encoded by EPXH₂ is a bifunctional enzyme with novel lipid phosphate phosphatase activity”. Proc. Natl. Acad. Sci. USA. 100: 1558—1563. PMID 12574510.
^ Cronin, A., Mowbray, S., Dürk, H., Homburg, S., Fleming, I., Fisslthaler, B., Oesch, F. and Arand, M. (2003). „The N-terminal domain of mammalian soluble epoxide hydrolase is a phosphatase”. Proc. Natl. Acad. Sci. USA. 100: 1552—1557. PMID 12574508.
^ Oesch, F. (1973). „Mammalian epoxide hydrases: inducible enzymes catalysing the inactivation of carcinogenic and cytotoxic metabolites derived from aromatic and olefinic compounds”. Xenobiotica. 3: 305—340. PMID 4584115.
^ Morisseau, C. & Hammock, B.D. (2005). „Epoxide hydrolases: mechanisms, inhibitor designs, and biological roles”. Annu. Rev. Pharmacol. Toxicol. 45: 311—333. PMID 15822179.
^ Yu, Z., Xu, F., Huse, L.M., Morisseau, C., Draper, A.J., Newman, J.W., Parker, C., Graham, L., Engler, M.M., Hammock, B.D., Zeldin, D.C. and Kroetz, D.L. (2000). „Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids”. Circ. Res. 87: 992—998. PMID 11090543.
^ Lacourciere, G.M. & Armstrong, R.N. (1993). „The catalytic mechanism of microsomal epoxide hydrolase involves an ester intermediate”. J. Am. Chem. Soc. 115: 10466—10456.
^ Fretland, A.J. & Omiecinski, C.J. (2000). „Epoxide hydrolases: biochemistry and molecular biology”. Chem. Biol. Interact. 129: 41—59. PMID 11154734.
^ Zeldin, D.C., Wei, S., Falck, J.R., Hammock, B.D., Snapper, J.R. and Capdevila, J.H. (1995). „Metabolism of epoxyeicosatrienoic acids by cytosolic epoxide hydrolase: substrate structural determinants of asymmetric catalysis”. Arch. Biochem. Biophys. 316: 443—451. PMID 7840649.
^ Haeggström, J., Meijer, J. and Rådmark, O. (1986). „Leukotriene A₄. Enzymatic conversion into 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid by mouse liver cytosolic epoxide hydrolase”. J. Biol. Chem. 261: 6332—6337. PMID 3009453.
^ Newman, J.W., Morisseau, C. and Hammock, B.D. (2005). „Epoxide hydrolases: their roles and interactions with lipid metabolism”. Prog. Lipid Res. 44: 1—51. PMID 15748653.