Gentamicin 3'-N-acetiltransferaza

Gentamicin 3'-N-acetiltransferaza
Identifikatori
EC broj	2.3.1.60
CAS broj	58500-58-6
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC članci PubMed članci NCBI proteini

Gentamicin 3'-N-acetiltransferaza (EC 2.3.1.60, gentamicinska acetiltransferaza I, aminoglikozidna acetiltransferaza AAC(3)-1, gentamicinska 3'-N-acetiltransferaza, acetil-KoA:gentamicin-C N^3'-acetiltransferaza) je enzim sa sistematskim imenom acetil-KoA:gentamicin-C N^3'-acetiltransferaza.^[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

acetil-KoA + gentamicin C ${\displaystyle \rightleftharpoons }$ KoA + N^3'-acetilgentamicin C

Ovaj enzim takođe acetiluje sisomicin.

Reference

1. Angelatou, F., Litsas, S.B. and Kontomichalou, P. (1982). „Purification and properties of two gentamicin-modifying enzymes, coded by a single plasmid pPK237 originating from Pseudomonas aeruginosa”. J. Antibiot. 35: 235—244. PMID 6281224. CS1 одржавање: Вишеструка имена: списак аутора (веза)
2. Biddlecome, S., Haas, J., Davies, G.H., Miller, D., Rane, F. and Daniels, P.J.L. (1976). „Enzymatic modification of aminoglycoside antibiotics: a new 3-N-acetylating enzyme from a Pseudomonas aeruginosa isolate”. Antimicrob. Agents Chemother. 9: 951—955. PMID 820250. CS1 одржавање: Вишеструка имена: списак аутора (веза)
3. Williams, J.W. & Northrop, D.B. (1976). „Purification and properties of gentamicin acetyltransferase I”. Biochemistry. 15: 125—131. PMID 764855. 

Literatura

• Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036. 
• Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097. 
• William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605. 

Spoljašnje veze

• Gentamicin+3'-N-acetyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)