Fludarabin

Fludarabin

Klinički podaci
Prodajno ime	Fludara, Fludura
Drugs.com	Monografija
Način primene	Intravenozno, oralno
Farmakokinetički podaci
Poluvreme eliminacije	20 h
Identifikatori
CAS broj	75607-67-9^Y
ATC kod	L01BB05 (WHO)
PubChem	CID 30751
DrugBank	DB01073^Y
ChemSpider	28532^Y
ChEMBL	CHEMBL1568^Y
Hemijski podaci
Formula	C10H13FN5O7P
Molarna masa	365,212
SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]3O)C2=NC(F)=N1
InChI InChI=1S/C10H13FN5O7P/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,17-18H,1H2,(H2,12,14,15)(H2,19,20,21)/t3-,5-,6+,9-/m1/s1^Y Key:GIUYCYHIANZCFB-FJFJXFQQSA-N^Y
Fizički podaci
Tačka topljenja	260 °C (500 °F)

Fludarabin je organsko jedinjenje, koje sadrži 10 atoma ugljenika i ima molekulsku masu od 365,212 Da.^{[1][2][3][4][5]}

Osobine

Osobina	Vrednost
Broj akceptora vodonika	11
Broj donora vodonika	5
Broj rotacionih veza	4
Particioni koeficijent[6] (ALogP)	-1,4
Rastvorljivost[7] (logS, log(mol/L))	-0,2
Polarna površina[8] (PSA, Å^2)	195,9

Reference

1. Rai, Kanti R.; Peterson, Bercedis L.; Appelbaum, Frederick R.; Kolitz, Jonathan; Elias, Laurence; Shepherd, Lois; Hines, John; Threatte, Gregory A.; Larson, Richard A.; Cheson, Bruce D.; Schiffer, Charles A. (2000). „Fludarabine Compared with Chlorambucil as Primary Therapy for Chronic Lymphocytic Leukemia”. New England Journal of Medicine. 343 (24): 1750—7. PMID 11114313. doi:10.1056/NEJM200012143432402. 
2. Gonzalez, H.; Leblond, V.; Azar, N.; Sutton, L.; Gabarre, J.; Binet, J. L.; Vernant, J. P.; Dighiero, G. (јун 1998). „Severe autoimmune hemolytic anemia in eight patients treated with fludarabine”. Hematology and Cell Therapy. 40 (3): 113—8. PMID 9698219. CS1 одржавање: Формат датума (веза)
3. Tournilhac, O. (2004). „Impact of frontline fludarabine and cyclophosphamide combined treatment on peripheral blood stem cell mobilization in B-cell chronic lymphocytic leukemia”. Blood. 103 (1): 363—5. PMID 12969985. S2CID 45975001. doi:10.1182/blood-2003-05-1449. 
4. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.  уреди
5. David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.  уреди
6. Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o. 
7. Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.  уреди
8. Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.  уреди

Literatura

• Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803. 
• Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799. 

Spoljašnje veze

• Fludarabine

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